scholarly journals Preventive effect of insect tea primary leaf ( Malus sieboldii (Regal) Rehd.) extract on D‐galactose‐induced oxidative damage in mice

2020 ◽  
Vol 8 (9) ◽  
pp. 5160-5171
Author(s):  
Ruokun Yi ◽  
Xi Chen ◽  
Wenfeng Li ◽  
Jianfei Mu ◽  
Fang Tan ◽  
...  
Keyword(s):  
Oxidative Damage ◽  
Primary Leaf ◽  
Preventive Effect ◽  
Malus Sieboldii

Preventive effect of vitamin E on iron-induced oxidative damage in rabbit

2005 ◽  
Vol 21 (7-8) ◽  
pp. 239-242 ◽  
Author(s):  
Ahmet Koyu ◽  
Fehmi Ozguner ◽  
Sadettin Caliskan ◽  
Halit Karaca
Keyword(s):  
Vitamin E ◽  
Oxidative Damage ◽  
Preventive Effect

scholarly journals Gongjin-Dan Enhances Neurite Outgrowth of Cortical Neuron by Ameliorating H2O2-Induced Oxidative Damage via Sirtuin1 Signaling Pathway

Nutrients ◽  
2021 ◽  
Vol 13 (12) ◽  
pp. 4290
Author(s):  
Hyunseong Kim ◽  
Wanjin Jeon ◽  
Jinyoung Hong ◽  
Junseon Lee ◽  
Changhwan Yeo ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Oxidative Damage ◽  
Signaling Pathway ◽  
Cortical Neurons ◽  
Neurological Diseases ◽  
Preventive Effect ◽  
Neuroprotective Effects ◽  
Mature Neuron ◽  
Pre Treatment ◽  
And Oxidative Stress

Gongjin-dan (GJD) is a multiherbal formula produced from 10 medicinal herbs and has been traditonally used as an oriental medicine to treat cardiovascular diseases, alcoholic hepatitis, mild dementia, and anemia. Additionally, increasing evidence suggests that GJD exerts neuroprotective effects by suppressing inflammation and oxidative stress-induced events to prevent neurological diseases. However, the mechanism by which GJD prevents oxidative stress-induced neuronal injury in a mature neuron remains unknown. Here, we examined the preventive effect and mechanism of GJD on primary cortical neurons exposed to hydrogen peroxide (H2O2). In the neuroprotection signaling pathway, Sirtuin1 is involved in neuroprotective action as a therapeutic target for neurological diseases. After pre-treatment with GJD at three concentrations (10, 25, and 50 µg/mL) and stimulation by H2O2 (30 µM) for 24 h, the influence of GJD on Sirtuin1 activation was assessed using immunocytochemistry, real-time PCR, western blotting, and flow cytometry. GJD effectively ameliorated H2O2-induced neuronal death against oxidative damage through Sirtuin1 activation. In addition, GJD-induced Sirtuin1 activation accelerated elongation of new axons and formation of synapses via increased expression of nerve growth factor and brain-derived neurotrophic factor, as well as regeneration-related genes. Thus, GJD shows potential for preventing neurological diseases via Sirtuin1 activation.

scholarly journals Preventive effect of safranal against oxidative damage in aged male rat brain

2015 ◽  
Vol 64 (1) ◽  
pp. 65-71 ◽  
Author(s):  
Saeed SAMARGHANDIAN ◽  
Mohsen AZIMI-NEZHAD ◽  
Fariborz SAMINI
Keyword(s):  
Oxidative Damage ◽  
Rat Brain ◽  
Male Rat ◽  
Preventive Effect

scholarly journals Preventive Effect of Lactobacillus Plantarum HFY15 on Oxidative Damage and Acute Liver Injury Induced by Carbon Tetrachloride (CCl 4 ) in Mice

2021 ◽  
Author(s):  
Xingyao Long ◽  
Pan Wang ◽  
Yujing Zhou ◽  
Qiang Wang ◽  
Lixuan Ren ◽  
...  
Keyword(s):  
Carbon Tetrachloride ◽  
Liver Injury ◽  
Oxidative Damage ◽  
Lactobacillus Plantarum ◽  
Acute Liver Injury ◽  
Animal Experiments ◽  
B Cell Lymphoma ◽  
Related Factor ◽  
Preventive Effect ◽  
Antioxidant Genes

Abstract BackgroundCarbon tetrachloride (CCl4) is a widely used hepatic toxin that causes acute liver injury through pathological mechanisms such as oxidative stress, inflammation, and apoptosis. In this experiment, mice were treated with Lactobacillus plantarum (LP) HFY15, silymarin, and Lactobacillus delbruechii subsp. bulgaricus (LDSB) for two weeks, and intraperitoneal injection of CCl4-induced acute liver injury to study the preventive effect of LP-HFY on CCl4-induced acute liver injury, especially in oxidative damage. ResultsThe survival rate of LP-HFY15 in artificial gastric juice is 92.1%, and the growth efficiency in bile salt is 78.8%. Animal experiments show that LP-HFY15 reduces the liver index of mice, reduces the activity of alanine aminotransferase (ALT) and aspartate aminotransferase (AST), the content of triglycerides (TG), malondialdehyde (MDA) and reactive oxygen species (ROS) in the serum of mice. LP-HFY15 also increased the antioxidant genes, such as nuclear factor erythroid 2-related factor 2 (Nrf2), heme oxygenase (HO-1), NAD(P)H:quinone oxidoreductase (NQO1), and increases the activity of superoxide dismutation (SOD), catalase (CAT), and glutathione (GSH) in the serum and gene level. At the same time, LP-HFY15 reduced the levels of cytokines IL-6, TNF-α, and IFN-γ in the serum and liver, increased antiapoptosis gene B-cell lymphoma-2 (Bcl-2) expression in the liver of mice, and inhibit the expression of proapoptotic genes Bcl-2-associated X (Bax) and Caspase-3. ConclusionsCompared with LDSB, LP-HFY15 has a greater alleviating effect on the liver injury caused by CCl4. These findings demonstrate that LP-HFY15 has great potential and research value in the future as a food supplement for preventing acute liver damage.

scholarly journals Preventive effect of Nile tilapia hydrolysate against oxidative damage of HepG2 cells and DNA mediated by H2O2 and AAPH

2015 ◽  
Vol 52 (10) ◽  
pp. 6194-6205 ◽  
Author(s):  
Suthasinee Yarnpakdee ◽  
Soottawat Benjakul ◽  
Hordur G. Kristinsson ◽  
Hilma Eiðsdóttir Bakken
Keyword(s):  
Oxidative Damage ◽  
Hepg2 Cells ◽  
Nile Tilapia ◽  
Preventive Effect
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