scholarly journals Malvidin induces hepatic stellate cell apoptosis via the endoplasmic reticulum stress pathway and mitochondrial pathway

2020 ◽  
Vol 8 (9) ◽  
pp. 5095-5106 ◽  
Author(s):  
Yanhong Ma ◽  
Yahui Li ◽  
Hongzhi Zhang ◽  
Ying Wang ◽  
Caie Wu ◽  
...  
Keyword(s):  
Endoplasmic Reticulum ◽  
Endoplasmic Reticulum Stress ◽  
Hepatic Stellate Cell ◽  
Cell Apoptosis ◽  
Stellate Cell ◽  
Mitochondrial Pathway ◽  
Endoplasmic Reticulum Stress Pathway ◽  
Stress Pathway

scholarly journals Mechanism of oxymatrine-induced human esophageal cancer cell apoptosis by the endoplasmic reticulum stress pathway

2018 ◽  
Vol 13 (1) ◽  
pp. 112-118 ◽  
Author(s):  
Baiyan Wang ◽  
Huiru Zhou ◽  
Yanqin Zhu
Keyword(s):  
Endoplasmic Reticulum ◽  
Esophageal Cancer ◽  
Endoplasmic Reticulum Stress ◽  
Cell Apoptosis ◽  
Binding Protein ◽  
Homologous Protein ◽  
Enhancer Binding Protein ◽  
Human Esophageal Cancer ◽  
Endoplasmic Reticulum Stress Pathway ◽  
Stress Pathway

AbstractEndoplasmic reticulum stress is one of the mechanisms of cell apoptosis. In this study, the mechanism of oxymatrine-induced human esophageal cancer Eca-109 cell apoptosis by the endoplasmic reticulum stress pathway was investigated. Eca-109 cells were cultured in vitro with different doses of oxymatrine (0.5, 1, 2 μg/mL) for 48 h. The cell viability and proliferation inhibition rate were examined by MTT assay and cell cycle assay. The apoptosis rate was examined by Annexin V-FITC/propidium iodide assay. The expression of endoplasmic reticulum stress markers, including binding immunoglobulin protein and CCAAT-enhancer-binding protein homologous protein, were determined by real-time quantitative polymerase chain reaction and western blotting, respectively. MTT data showed that oxymatrine significantly inhibited the proliferation of Eca-109 cells. The cell apoptosis rate was quantified by flow cytometry. The expression of binding immunoglobulin protein was markedly downregulated in oxymatrine-treated Eca-109 cells while that of CCAAT-enhancer-binding protein homologous protein was upregulated. Oxymatrine inhibited proliferation and induced apoptosis of human esophageal carcinoma Eca-109 cells. Thus, oxymatrine may be a potential agent for treating human esophageal cancer.

scholarly journals Endoplasmic Reticulum stress induces hepatic stellate cell apoptosis and contributes to fibrosis resolution

2012 ◽  
Vol 32 (10) ◽  
pp. 1574-1584 ◽  
Author(s):  
Samuele De Minicis ◽  
Cinzia Candelaresi ◽  
Laura Agostinelli ◽  
Silvia Taffetani ◽  
Stefania Saccomanno ◽  
...  
Keyword(s):  
Endoplasmic Reticulum ◽  
Endoplasmic Reticulum Stress ◽  
Hepatic Stellate Cell ◽  
Cell Apoptosis ◽  
Stellate Cell
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