scholarly journals Enhancement of glucose homeostasis through the PI3K/Akt signaling pathway by dietary with Agaricus blazei Murrill in STZ‐induced diabetic rats

2020 ◽  
Vol 8 (2) ◽  
pp. 1104-1114
Author(s):  
Qi Wei ◽  
Jie Li ◽  
Yishu Zhan ◽  
Qiangui Zhong ◽  
Baogui Xie ◽  
...  
Keyword(s):  
Signaling Pathway ◽  
Glucose Homeostasis ◽  
Akt Signaling ◽  
Diabetic Rats ◽  
Agaricus Blazei ◽  
Akt Signaling Pathway

Blood glucose fluctuation accelerates renal injury involved to inhibit the AKT signaling pathway in diabetic rats

Endocrine ◽  
2016 ◽  
Vol 53 (1) ◽  
pp. 81-96 ◽  
Author(s):  
Changjiang Ying ◽  
Xiaoyan Zhou ◽  
Zhenzhen Chang ◽  
Hongwei Ling ◽  
Xingbo Cheng ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Signaling Pathway ◽  
Renal Injury ◽  
Akt Signaling ◽  
Diabetic Rats ◽  
Akt Signaling Pathway ◽  
Glucose Fluctuation ◽  
Blood Glucose Fluctuation

scholarly journals Body temperature elevation during exercise is essential for activating the Akt signaling pathway in the skeletal muscle of type 2 diabetic rats

PLoS ONE ◽  
2018 ◽  
Vol 13 (10) ◽  
pp. e0205456 ◽  
Author(s):  
Takamasa Tsuzuki ◽  
Toshinori Yoshihara ◽  
Noriko Ichinoseki-Sekine ◽  
Ryo Kakigi ◽  
Yuri Takamine ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Body Temperature ◽  
Signaling Pathway ◽  
Akt Signaling ◽  
Diabetic Rats ◽  
Temperature Elevation ◽  
Akt Signaling Pathway ◽  
Type 2 Diabetic

scholarly journals Foxtail Millet Improves Blood Glucose Metabolism in Diabetic Rats through PI3K/AKT and NF-κB Signaling Pathways Mediated by Gut Microbiota

Nutrients ◽  
2021 ◽  
Vol 13 (6) ◽  
pp. 1837
Author(s):  
Xin Ren ◽  
Linxuan Wang ◽  
Zenglong Chen ◽  
Dianzhi Hou ◽  
Yong Xue ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Signaling Pathways ◽  
Signaling Pathway ◽  
Relative Abundance ◽  
Foxtail Millet ◽  
Acid Synthesis ◽  
Akt Signaling ◽  
Diabetic Rats ◽  
Hypoglycemic Effect ◽  
Akt Signaling Pathway

Foxtail millet (FM) is receiving ongoing increased attention due to its beneficial health effects, including the hypoglycemic effect. However, the underlying mechanisms of the hypoglycemic effect have been underexplored. In the present study, the hypoglycemic effect of FM supplementation was confirmed again in high-fat diet and streptozotocin-induced diabetic rats with significantly decreased fasting glucose (FG), glycated serum protein, and areas under the glucose tolerance test (p < 0.05). We employed 16S rRNA and liver RNA sequencing technologies to identify the target gut microbes and signaling pathways involved in the hypoglycemic effect of FM supplementation. The results showed that FM supplementation significantly increased the relative abundance of Lactobacillus and Ruminococcus_2, which were significantly negatively correlated with FG and 2-h glucose. FM supplementation significantly reversed the trends of gene expression in diabetic rats. Specifically, FM supplementation inhibited gluconeogenesis, stimulated glycolysis, and restored fatty acid synthesis through activation of the PI3K/AKT signaling pathway. FM also reduced inflammation through inhibition of the NF-κB signaling pathway. Spearman’s correlation analysis indicated a complicated set of interdependencies among the gut microbiota, signaling pathways, and metabolic parameters. Collectively, the above results suggest that the hypoglycemic effect of FM was at least partially mediated by the increased relative abundance of Lactobacillus, activation of the PI3K/AKT signaling pathway, and inhibition of the NF-κB signaling pathway.

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