scholarly journals Astaxanthin inhibits aldose reductase activity in Psammomys obesus , a model of type 2 diabetes and diabetic retinopathy

2019 ◽  
Vol 7 (12) ◽  
pp. 3979-3985 ◽  
Author(s):  
Maha Benlarbi‐Ben Khedher ◽  
Khouloud Hajri ◽  
Ahmed Dellaa ◽  
Basma Baccouche ◽  
Imane Hammoum ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Diabetic Retinopathy ◽  
Aldose Reductase ◽  
Reductase Activity ◽  
Psammomys Obesus

Aldose reductase (AC)n gene polymorphism and susceptibility to diabetic retinopathy in Type 2 diabetes in Caucasians

2005 ◽  
Vol 19 (2) ◽  
pp. 70-73 ◽  
Author(s):  
Mojca Globočnik Petrovič ◽  
Borut Peterlin ◽  
Marko Hawlina ◽  
Daniel Petrovič
Keyword(s):  
Type 2 Diabetes ◽  
Diabetic Retinopathy ◽  
Gene Polymorphism ◽  
Aldose Reductase ◽  
N Gene

scholarly journals Aldose Reductase Inhibitiory Effect of Gymnemic Acid, Trigonelline and Ferulic Acid- An In Silico Approach

2017 ◽  
Vol 9 (1) ◽  
Author(s):  
Roshana Devi Vellai ◽  
Subramanian Sorimuthu Pillai
Keyword(s):  
Type 2 Diabetes ◽  
Diabetic Retinopathy ◽  
Ferulic Acid ◽  
Aldose Reductase ◽  
In Silico ◽  
Inhibitory Effect ◽  
Computational Method ◽  
Gymnemic Acid ◽  
Chronic Hyperglycemia

Diabetic retinopathy (DR) is one of the earliest complications of chronic hyperglycemia and is a major cause of vision loss. Nearly all patients with type 1 diabetes mellitus and more than 60 % with chronic type 2 diabetes develop some degree of retinopathy after 10 years. Aldose reductase, the first enzyme in polyol pathway chiefly contributes to the development of diabetic retinopathy and other secondary complications. None of the currently available drugs used to inhibit the activity of aldose reductase is found to be ideal due to their adverse effects. Hence, the screening and identification of more effective and safer aldose reductase inhibitors from natural products have been critical requirement in the management and treatment of T2DM. Recently, we have reported the antidiabetic properties of phytochemicals such as Gymnemic acid, Trigonelline and Ferulic acid in high fat diet fed- low dose STZ induced experimental type 2 diabetes in rats. In the present study, the structure based computational method was employed to identify the in silico inhibitory effect of the above phytoingredients on aldose reductase activity. Auto Dock 4.2 is used to study the molecular interactions between the ligands and the receptor. The data obtained evidenced that the docking efficacy of the antidiabetic ligands which are comparable with fidarestat, the standard used in the present study. Thus, the antidiabetic properties of the above lead molecules may attribute to its aldose reductase inhibitory effect.

The −106CC genotype of the aldose reductase gene is associated with an increased risk of proliferative diabetic retinopathy in Caucasian-Brazilians with type 2 diabetes

2006 ◽  
Vol 88 (3) ◽  
pp. 280-284 ◽  
Author(s):  
Kátia Gonçalves dos Santos ◽  
Luís Henrique Canani ◽  
Jorge Luiz Gross ◽  
Balduíno Tschiedel ◽  
Kátia Elisabete Pires Souto ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Diabetic Retinopathy ◽  
Aldose Reductase ◽  
Proliferative Diabetic Retinopathy ◽  
Increased Risk ◽  
Reductase Gene

Aldose reductase C-106T gene polymorphism is associated with diabetic retinopathy in Japanese patients with type 2 diabetes

2011 ◽  
Vol 92 (3) ◽  
pp. e57-e60 ◽  
Author(s):  
N. Katakami ◽  
H. Kaneto ◽  
M. Takahara ◽  
T.A. Matsuoka ◽  
K. Imamura ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Diabetic Retinopathy ◽  
Gene Polymorphism ◽  
Aldose Reductase ◽  
Japanese Patients

Angiopoietin 1 in patients with type 2 diabetes mellitus and diabetic retinopathy

2015 ◽  
Author(s):  
Sattar El-Deeb Abd El ◽  
Mohamed Halawa ◽  
Ahmed Saad ◽  
Inas Sabry ◽  
Maram Mahdy ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Diabetic Retinopathy ◽  
Angiopoietin 1

592-P: Diabetic Retinopathy Grade as Predictor of Outcomes in Patients with Type 2 Diabetes and Lower Extremity Amputations—Multicentric Longitudinal Seven-Year Study

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 592-P
Author(s):  
KIRAN SHAH ◽  
SUNDARAM NATARAJAN ◽  
VISHWANATH PARSEWAR ◽  
VYANKATESH K. SHIVANE
Keyword(s):  
Type 2 Diabetes ◽  
Diabetic Retinopathy ◽  
Lower Extremity
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