scholarly journals Allium vegetable consumption and health: An umbrella review of meta‐analyses of multiple health outcomes

2019 ◽  
Vol 7 (8) ◽  
pp. 2451-2470 ◽  
Author(s):  
Qianyi Wan ◽  
Ni Li ◽  
Liang Du ◽  
Rui Zhao ◽  
Mengshi Yi ◽  
...  
Keyword(s):  
Health Outcomes ◽  
Vegetable Consumption ◽  
Umbrella Review ◽  
Meta Analyses ◽  
Multiple Health

scholarly journals Milk consumption and multiple health outcomes: umbrella review of systematic reviews and meta-analyses in humans

2021 ◽  
Vol 18 (1) ◽  
Author(s):  
Xingxia Zhang ◽  
Xinrong Chen ◽  
Yujie Xu ◽  
Jie Yang ◽  
Liang Du ◽  
...  
Keyword(s):  
Health Outcomes ◽  
Systematic Reviews ◽  
Milk Intake ◽  
Milk Consumption ◽  
Umbrella Review ◽  
Randomized Controlled ◽  
Health Related ◽  
Meta Analyses ◽  
Multiple Health

AbstractIn order to recapitulate the best available evidence of milk consumption and multiple health-related outcomes, we performed an umbrella review of meta-analyses and systematic reviews in humans. Totally, 41 meta-analyses with 45 unique health outcomes were included. Milk consumption was more often related to benefits than harm to a sequence of health-related outcomes. Dose–response analyses indicated that an increment of 200 ml (approximately 1 cup) milk intake per day was associated with a lower risk of cardiovascular disease, stroke, hypertension, colorectal cancer, metabolic syndrome, obesity and osteoporosis. Beneficial associations were also found for type 2 diabetes mellitus and Alzheimer's disease. Conversely, milk intake might be associated with higher risk of prostate cancer, Parkinson’s disease, acne and Fe-deficiency anaemia in infancy. Potential allergy or lactose intolerance need for caution. Milk consumption does more good than harm for human health in this umbrella review. Our results support milk consumption as part of a healthy diet. More well-designed randomized controlled trials are warranted.

scholarly journals Association Between Folate and Health Outcomes: An Umbrella Review of Meta-Analyses

2020 ◽  
Vol 8 ◽  
Author(s):  
Yacong Bo ◽  
Yongjian Zhu ◽  
Yuchang Tao ◽  
Xue Li ◽  
Desheng Zhai ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Health Outcomes ◽  
Chronic Diseases ◽  
Observational Studies ◽  
Meta Analysis ◽  
Current Evidence ◽  
Umbrella Review ◽  
All Cause Mortality ◽  
Meta Analyses ◽  
Multiple Health

Background: There is no study that has systematically investigated the breadth and validity of the associations of folate and multiple health outcomes. We aimed to evaluate the quantity, validity, and credibility of evidence regarding associations between folate and multiple health outcomes by using umbrella review of meta-analysis.Methods: We searched the MEDLINE, EMBASE, and Cochrane Library databases from inception to May 20, 2018, to identify potential meta-analyses that examined the association of folate with any health outcome. For each included meta-analysis, we estimated the summary effect size and their 95% confidence interval using the DerSimonian and Laird random-effects model. We used the AMSTAR 2 (A Measurement Tool to Assess Systematic Reviews) to assess methodological quality and the GRADE (Grading of Recommendations, Assessment, Development, and Evaluation working group classification) to assess the quality of evidence for each outcome included in the umbrella review.Results: Overall, 108 articles reporting 133 meta-analyses of observational studies and 154 meta-analyses of randomized controlled trials (RCTs) were included in the study. Among them, 108 unique exposure–outcome–population triplets (referred to as unique meta-analyses hereafter) of RCTs and 87 unique meta-analyses of observational studies were reanalyzed. Beneficial effects of folate were observed in the all-cause mortality rate and in a number of chronic diseases, including several birth/pregnancy outcomes, several cancers, cardiovascular disease and metabolic-related outcomes, neurological conditions, and several other diseases. However, adverse effects of folate were observed for prostate cancer, colorectal adenomatous lesions, asthma or wheezing, and wheezing as an isolated symptom and depression.Conclusions: Current evidence allows for the conclusion that folate is associated with decreased risk of all-cause mortality and a wide range of chronic diseases. However, folate may be associated with an increased risk of prostate cancer. Further research is warranted to improve the certainty of the estimates.

scholarly journals Coffee consumption and health: umbrella review of meta-analyses of multiple health outcomes

BMJ ◽  
2017 ◽  
pp. j5024 ◽  
Author(s):  
Robin Poole ◽  
Oliver J Kennedy ◽  
Paul Roderick ◽  
Jonathan A Fallowfield ◽  
Peter C Hayes ◽  
...  
Keyword(s):  
Health Outcomes ◽  
Coffee Consumption ◽  
Umbrella Review ◽  
Meta Analyses ◽  
Multiple Health

The Dietary Inflammatory Index and Human Health: An Umbrella Review of Meta-Analyses of Observational Studies

2021 ◽  
Author(s):  
Wolfgang Marx ◽  
Nicola Veronese ◽  
Jaimon T Kelly ◽  
Lee Smith ◽  
Meghan Hockey ◽  
...  
Keyword(s):  
Chronic Disease ◽  
Health Outcomes ◽  
Observational Studies ◽  
Dietary Inflammatory Index ◽  
Credibility Assessment ◽  
Umbrella Review ◽  
Inflammatory Index ◽  
Increased Risk ◽  
Meta Analyses ◽  
Study Designs

ABSTRACT Numerous observational studies have investigated the role of the Dietary Inflammatory Index (DII®) in chronic disease risk. The aims of this umbrella review and integrated meta-analyses were to systematically synthesize the observational evidence reporting on the associations between the DII and health outcomes based on meta-analyses, and to assess the quality and strength of the evidence for each associated outcome. This umbrella review with integrated meta-analyses investigated the association between the DII and a range of health outcomes based on meta-analyses of observational data. A credibility assessment was conducted for each outcome using the following criteria: statistical heterogeneity, 95% prediction intervals, evidence for small-study effect and/or excess significance bias, as well as effect sizes and P values using calculated random effects meta-analyses. In total, 15 meta-analyses reporting on 38 chronic disease-related outcomes were included, incorporating a total population of 4,360,111 subjects. Outcomes (n = 38) were examined through various study designs including case-control (n = 8), cross-sectional (n = 5), prospective (n = 5), and combination (n = 20) study designs. Adherence to a pro-inflammatory dietary pattern had a significant positive association with 27 (71%) of the included health outcomes (P value < 0.05). Using the credibility assessment, Class I (Convincing) evidence was identified for myocardial infarction only, Class II (Highly suggestive) evidence was identified for increased risk of all-cause mortality, overall risk of incident cancer, and risk of incident site-specific cancers (colorectal, pancreatic, respiratory, and oral cancers) with increasing (more pro-inflammatory) DII score. Most outcomes (n = 31) presented Class III (Suggestive) or lower evidence (Weak or No association). Pro-inflammatory dietary patterns were nominally associated with an increased risk of many chronic disease outcomes. However, the strength of evidence for most outcomes was limited. Further prospective studies are required to improve the precision of the effect size.

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