scholarly journals Computational modelling of 1D blood flow with variable mechanical properties and its application to the simulation of wave propagation in the human arterial system

2003 ◽  
Vol 43 (6-7) ◽  
pp. 673-700 ◽  
Author(s):  
S. J. Sherwin ◽  
L. Formaggia ◽  
J. Peiró ◽  
V. Franke
Keyword(s):  
Mechanical Properties ◽  
Blood Flow ◽  
Wave Propagation ◽  
Computational Modelling ◽  
Arterial System

ASME Centennial Historical Perspective Paper: Mechanics of Blood Flow

1981 ◽  
Vol 103 (2) ◽  
pp. 102-115 ◽  
Author(s):  
R. Skalak ◽  
S. R. Keller ◽  
T. W. Secomb
Keyword(s):  
Blood Flow ◽  
Wave Propagation ◽  
Viscoelastic Behavior ◽  
Leonardo Da Vinci ◽  
Arterial System ◽  
Elastic Membrane ◽  
Biological Knowledge ◽  
Collapsible Tubes ◽  
Precise Understanding ◽  
Leonhard Euler

The historical development of the mechanics of blood flow can be traced from ancient times, to Leonardo da Vinci and Leonhard Euler and up to the present times with increasing biological knowledge and mathematical analysis. In the last two decades, quantitative and numerical methods have steadily given more complete and precise understanding. In the arterial system wave propagation computations based on nonlinear one-dimensional modeling have given the best representation of pulse wave propagation. In the veins, the theory of unsteady flow in collapsible tubes has recently been extensively developed. In the last decade, progress has been made in describing the blood flow at junctions, through stenoses, in bends and in capillary blood vessels. The rheological behavior of individual red blood cells has been explored. A working model consists of an elastic membrane filled with viscous fluid. This model forms a basis for understanding the viscous and viscoelastic behavior of blood.

scholarly journals Effects of Food Restriction on Mechanical Properties of Arterial System in Adult and Middle-Aged Rats

1999 ◽  
Vol 54 (10) ◽  
pp. B441-B447 ◽  
Author(s):  
K.-C. Chang ◽  
C.-Y. Chow ◽  
Y.-I. Peng ◽  
T.-J. Chen ◽  
Y.-F. Tsai
Keyword(s):  
Mechanical Properties ◽  
Food Restriction ◽  
Arterial System ◽  
Aged Rats ◽  
Middle Aged

Control of bat wing capillary pressure and blood flow during reduced perfusion pressure

1988 ◽  
Vol 255 (5) ◽  
pp. H1114-H1129 ◽  
Author(s):  
M. J. Davis
Keyword(s):  
Blood Flow ◽  
Capillary Pressure ◽  
Perfusion Pressure ◽  
Arterial System ◽  
Total Flow ◽  
Capillary Recruitment ◽  
Null System ◽  
Arteriolar Resistance ◽  
Sampling Procedures ◽  
Bat Wing

Regulation of blood flow depends on changes in the sum of arterial (Ra) and venous (Rv) resistances, whereas regulation of capillary pressure (Pc) depends on the ratio of Rv to Ra. If the myogenic response of the arterial system (i.e., delta Ra) is the primary mechanism for controlling pressure and flow when perfusion pressure is lowered, then Pc and total flow should be regulated to the same degree under these conditions. This hypothesis was tested by making direct measurements of Pc and flow in skin and skeletal muscle in the wings of unanesthetized bats. The box method was used to reduce perfusion pressure to the wing. Pressures were measured with a servo-null system; flows were computed from measurements of vascular diameters and red cell velocities using intravital microscopy. All branching orders of arterioles dilated significantly during decreases in box pressure (Pb). For 0 less than Pb less than or equal to -30 mmHg, total flow (1st-order arteriolar flow) remained nearly constant, whereas Pc was "regulated" only approximately 60%. These results cannot be explained by changes in arteriolar resistance alone and suggest that changes in Rv may be important. The possible consequences of flow redistribution, capillary recruitment, and micropressure sampling procedures are discussed in relationship to local regulation of capillary pressure and flow.

Impact of Vessel Mechanical Properties on Hemodynamic Parameters of Blood Flow

2017 ◽  
pp. 271-278 ◽  
Author(s):  
Wojciech Wolański ◽  
Bożena Gzik-Zroska ◽  
Kamil Joszko ◽  
Edyta Kawlewska ◽  
Marta Sobkowiak ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Blood Flow ◽  
Hemodynamic Parameters

scholarly journals Blood Flow in Human Arterial System-A Review

2016 ◽  
Vol 24 ◽  
pp. 339-346 ◽  
Author(s):  
Blessy Thomas ◽  
K.S. Sumam
Keyword(s):  
Blood Flow ◽  
Arterial System ◽  
System A

The numerical analysis of fluid-solid interactions for blood flow in arterial structures Part 2: Development of coupled fluid-solid algorithms

1998 ◽  
Vol 212 (4) ◽  
pp. 241-252 ◽  
Author(s):  
S Z Zhao ◽  
X Y Xu ◽  
M W Collins
Keyword(s):  
Blood Flow ◽  
Wave Propagation ◽  
Numerical Analysis ◽  
Blood Vessels ◽  
Applied Mechanics ◽  
Specific Topic ◽  
Numerical Techniques ◽  
Wall Effects ◽  
Clinical Context ◽  
Local Flow

In this paper, the authors extend their study of wall mechanics given in Part 1 to the overall problem of fluid-solid interactions in arterial flows. Fluid-solid coupling has become a specific topic in computational methods and applied mechanics. In this review, firstly, the effects of elasticity of blood vessels on wave propagation and local flow patterns in large arteries are discussed. Then, numerical techniques are reviewed together with the alternative coupled methods available in fluid—wall models. Finally, a novel numerical algorithm combining two commercial codes for coupled solid/fluid problems is presented. As a consequence of the present studies, wall effects are now able to be included in predictions of haemodynamics in a clinical context.

Dynamic Left Atrioventricular Phantom Test Bed Emulating Mitral Valve Motion

2020 ◽  
Vol 14 (3) ◽  
Author(s):  
Toufic Azar ◽  
Stewart McLennan ◽  
Michael Walsh ◽  
Jorge Angeles ◽  
Jozsef Kövecses ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Blood Flow ◽  
Polyvinyl Alcohol ◽  
Computer Aided Design ◽  
Human Heart ◽  
Numerical Control ◽  
Test Bed ◽  
Numerical Control Machining ◽  
Valve Motion ◽  
Test Beds

Abstract Novel catheter-based medical procedures targeting heart valve structures are currently under development. These techniques entail installing a prosthetic implant on valves inside a beating heart. The development of these approaches requires a simple and effective validation test bed. Current early process testing methods rely on both static and dynamically pressurized excised porcine hearts. The variability between excised-tissue mechanical properties poses problems of reproducibility. In addition, these test beds do not emulate annulus motion, which affects the implant installation. A reproducible phantom of the left atrioventricular chambers was developed. The system consists of a hydraulic constant flow arrangement and a polyvinyl alcohol phantom heart with material properties that mimic passive myocardium mechanical properties and annulus motion. The system was then used to emulate blood flow through an actual heart. The building process starts by obtaining an accurate computer-aided design (CAD) model of a human heart, from which, a mold is produced using a novel rapid-freezing prototyping method and computer numerical control machining. The phantom is then cast-out of polyvinyl alcohol (PVA), a hydrogel, whose mechanical properties are set by subjecting the phantom to freeze and thaw cycles. Subsequently, blood flow is emulated at a constant volumetric rate at the atrial pressure observed in a healthy adult human heart at rest. The annulus motion is implemented by suturing the outside of the phantom to a one-degree-of-freedom cam-follower mechanism reproducing valve motion. Such test beds could play a significant role in future development of medical devices.

Sign in / Sign up

Export Citation Format

Share Document