scholarly journals Contact sensitization to fragrance mix I and II, toMyroxylon pereiraeresin and oil of tupentine: multifactorial analysis of risk factors based on data of the IVDK network

2015 ◽  
Vol 30 (4) ◽  
pp. 255-263 ◽  
Author(s):  
Wolfgang Uter ◽  
Cornelia Fieβler ◽  
Olaf Gefeller ◽  
Johannes Geier ◽  
Axel Schnuch
2013 ◽  
Vol 69 (4) ◽  
pp. 231-238 ◽  
Author(s):  
Wolfgang Uter ◽  
Johannes Geier ◽  
Andrea Bauer ◽  
Axel Schnuch

2021 ◽  
Vol 2021 ◽  
pp. 1-8
Author(s):  
Yi Li ◽  
Dong Yang ◽  
Shuangjian Yang

Objective. Recurrence of endometrial cancer after initial treatment can be complex and difficult to treat. The current main treatment modalities for patients with recurrent endometrial cancer (REC) include chemotherapy, radiotherapy, and surgery, which vary according to the individual patient. However, REC is often associated with a poor prognosis, and it is therefore important to investigate the risk factors affecting REC prognosis and to explore appropriate treatment modalities to improve the prognosis and treatment strategies for patients with REC. Methods. Totally, 100 patients with REC admitted to our hospital from January 2013 to January 2018 were chosen to be research objects. Their pathological data were analyzed, including age, disease-free interval (DFI), recurrence site, and treatment plan after relapse (definitive local therapy (DLT) and palliative chemotherapy (PC)). According to these parameters, univariate and multivariate factors affecting the prognosis of REC patients and the curative effect of PC were analyzed, and the 3-year overall survival (OS) curve and progression-free survival (PFS) curve were drawn. Results. After 3 years of follow-up, 30 patients had a poor prognosis and 70 had a good prognosis, according to which a single multifactorial analysis was performed for different prognoses, where the results of the single-factor analysis showed significant differences between patients with different prognoses in terms of pathomorphology, pathological grading, TFI, and treatment modality after relapse. Further multifactorial analysis showed that TFI and treatment modality after recurrence were independent factors affecting poor prognosis in REC patients. The 3-year OS and 3-year PFS of REC patients were 74.00% and 70.00%, respectively. Patients whose DFI was less than 12 months or treated with PC after relapse were notably associated with lower levels of 3-year OS and 3-year PFS. In addition, radiotherapy and chemotherapy, DFI, and chemotherapy plan after primary surgery were independent risk factors that affected the PC efficacy of REC patients. Conclusion. DFI and treatment mode after relapse are independent factors affecting the prognosis of REC patients. DLT can obviously improve the prognosis of REC patients. For patients who can only choose PC, chemoradiotherapy and DFI after primary surgery are helpful to predict the chemotherapy effect, and the combination of paclitaxel and platinum drugs should be the first choice for chemotherapy.


Stroke ◽  
1994 ◽  
Vol 25 (5) ◽  
pp. 958-962 ◽  
Author(s):  
S M Lai ◽  
M Alter ◽  
G Friday ◽  
E Sobel

2021 ◽  
Vol 8 ◽  
Author(s):  
Sandro Gelsomino ◽  
Cecilia Tetta ◽  
Francesco Matteucci ◽  
Stefano del Pace ◽  
Orlando Parise ◽  
...  

Graphical AbstractFactors increasing post CABG incidence of ischemic stroke (red) and those which were not significant at the multi-model multifactorial analysis that analyzed all technical factors alone or in different combinations (green).


2015 ◽  
Vol 25 (10) ◽  
pp. 3303-3310 ◽  
Author(s):  
Hitoshi Shitara ◽  
Tsutomu Kobayashi ◽  
Atsushi Yamamoto ◽  
Daisuke Shimoyama ◽  
Tsuyoshi Ichinose ◽  
...  

2003 ◽  
Vol 11 (4) ◽  
pp. 249-254
Author(s):  
Vladimir Lezhnin ◽  
Eugene Polzik ◽  
Vladimir Kazantsev

BACKGROUND: We conducted a multifactorial cancer epidemiology case-control study to assess effects of a complex of factors on high cancer morbidity of population of an industrial town in the central part of Russia. The study was carried out in the town of Tula, one of the oldest industrial centers of Russia with a high occupational and industrial load on the population and a high cancer incidence rate exceeding the Russian average rates by 38.4% in men and 89.9% in women. METHODS: We examined 200 lung cancer cases, 206 stomach cancer cases, and 213 controls, all residents of Tula. On each of the 619 study participants we collected personal data, which allowed characterization of cases and controls by a complex of 29 features reflecting well-known lung and stomach cancer risk factors. Mathematical processing was performed using the technique of multifactorial analysis based on mathematical pattern recognition methods. All tasks were solved in the package of applied programs of pattern recognition KVAZAR. RESULTS: The results of the multifactorial analysis of epidemiological data collected showed that the contribution of smoking in the development of stomach cancer in Tula was 7%, alcohol abuse 4%, occupational exposure to carcinogens 12% a complex of individual biological factors 28%, environmental factors 22% radiation factors 5%, nutrition habits 10%, and other factors 12%. The contribution of smoking in lung cancer mortality was 27%, alcohol abuse 4% occupational exposure to carcinogens 14%, a complex of individual biological factors 32%, environmental factors 9%, radiation factors 7%, and other factors 7%. CONCLUSION: The results of the epidemiological study carried out on the basis of methods of a multifactorial analysis in the city of Tula Russia, showed the effectiveness of such an approach to solving complicated epidemiological tasks. The suggested method allows one to assess a complex effect of different factors on oncologic morbidity in an industrial town and the prediction of effectiveness of various cancer preventive measures facilitates the choice of the most effective complex of preventive actions on the certain territory and at low cost.


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