Application of Sharpless asymmetric epoxidation on the preparation of the optically active flavours 3-methylthiohexanal and 5(6)-butyl-1,4-dioxan-2-one

2010 ◽  
Vol 26 (1) ◽  
pp. 65-69 ◽  
Author(s):  
Hong-yu Tian ◽  
Bao-guo Sun ◽  
Li-wei Tang ◽  
Hong-lin Ye
Keyword(s):  
Optically Active ◽  
Asymmetric Epoxidation ◽  
Sharpless Asymmetric Epoxidation

An efficient synthesis of an optically active (-)-(3R, 4R, 5R)-4-(1-hydroxyl-isopropyl)-3-acetyloxyl-butyrolactone

2005 ◽  
Vol 2005 (10) ◽  
pp. 665-668 ◽  
Author(s):  
JinXin Wang ◽  
ChaoXin Zhang ◽  
Ying Li ◽  
QiDong You
Keyword(s):  
Crystal Structure ◽  
Optically Active ◽  
Reductive Cleavage ◽  
Starting Material ◽  
Asymmetric Epoxidation ◽  
Efficient Synthesis ◽  
Cleavage Reaction ◽  
X Ray ◽  
Key Steps ◽  
Sharpless Asymmetric Epoxidation

An optically active β-hydroxyl–γ-butyrolactone was synthesised from nonchiral starting material by employing reductive cleavage reaction, Sharpless asymmetric epoxidation and dihydroxylation as key steps. This strategy can be used to prepare many chiral β-hydroxyl–γ-butyrolactone analogues. The crystal structure of 10 was determined by X-ray crystallographs.

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