Structure-activity relationship for bromoindole carbaldehydes: Effects on the sea urchin embryo cell cycle

2001 ◽  
Vol 20 (3) ◽  
pp. 589-596 ◽  
Author(s):  
Isabelle Moubax ◽  
Nathalie Bontemps-Subielos ◽  
Bernard Banaigs ◽  
Georges Combaut ◽  
Philippe Huitorel ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Sea Urchin ◽  
Structure Activity Relationship ◽  
Embryo Cell ◽  
Activity Relationship ◽  
Structure Activity ◽  
Sea Urchin Embryo

STRUCTURE–ACTIVITY RELATIONSHIP FOR BROMOINDOLE CARBALDEHYDES: EFFECTS ON THE SEA URCHIN EMBRYO CELL CYCLE

2001 ◽  
Vol 20 (3) ◽  
pp. 589 ◽  
Author(s):  
Isabelle Moubax ◽  
Nathalie Bontemps-Subielos ◽  
Bernard Banaigs ◽  
Georges Combaut ◽  
Philippe Huitorel ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Sea Urchin ◽  
Structure Activity Relationship ◽  
Embryo Cell ◽  
Activity Relationship ◽  
Structure Activity ◽  
Sea Urchin Embryo

Synthesis of Hippospongic Acid A Analogues Designed for Investigating the Structure-Activity Relationship of its Biological Activity

2000 ◽  
Vol 53 (12) ◽  
pp. 909 ◽  
Author(s):  
Yoshikazu Hiraga ◽  
Mariko Ago ◽  
Munetaka Tokumasu ◽  
Ken Kaku ◽  
Katsuo Ohkata
Keyword(s):  
Biological Activity ◽  
Carboxylic Acid ◽  
Sea Urchin ◽  
Essential Feature ◽  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Acid Moiety ◽  
Sea Urchin Embryos ◽  
Structure Activity ◽  
Relationship Of

Analogues of hippospongic acid A, which inhibit the gastrulation of sea urchin embryos, were synthesized. From a study on structure—activity relationships, the conjugated carboxylic acid moiety was found to be an essential feature for biological activity.

Discovery of novel 2-aminonicotinonitrile derivatives with new potential autophagy activity

2020 ◽  
Vol 12 (15) ◽  
pp. 1399-1414
Author(s):  
Pinghu Zhang ◽  
Zuguo Zheng ◽  
Xiaohui Yang ◽  
Yuqian Zhang ◽  
Gendi Hu ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Opposite Effect ◽  
Structure Activity Relationship ◽  
Activity Relationship ◽  
G1 Arrest ◽  
The Novel ◽  
Relationship Analysis ◽  
Structure Activity ◽  
First Time ◽  
Autophagy Activity

Background: To clarify the molecular mechanism of novel 2-aminonicotinonitrile autophagy enhancers, two series of novel 2-aminonicotinonitrile derivatives are synthesized and their structure–activity relationship and biological activity were analyzed. Results & methodology: Structure–activity relationship analysis revealed that substituents at C-4 and C-6 position of 7a contribute to enhance their autophagy-inducing activity, while C-5 position substituents have the opposite effect. The most promising compound 7g showed the strongest autophagy-inducing activity and better antiproliferative activity by inducing cell apoptosis and blocking cell cycle G1 arrest in SGC-7901 cells. Conclusion: The novel 2-aminonicotinonitrile autophagy enhancers were for the first time discovered and 7g might be a promising new autophagy enhancer with potential anticancer activity.

Structure–activity relationship between carboxylic acids and T cell cycle blockade

Life Sciences ◽  
2006 ◽  
Vol 78 (19) ◽  
pp. 2159-2165 ◽  
Author(s):  
Kathleen M. Gilbert ◽  
Annick DeLoose ◽  
Jimmie L. Valentine ◽  
E. Kim Fifer
Keyword(s):  
Cell Cycle ◽  
T Cell ◽  
Carboxylic Acids ◽  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Structure Activity

Structure-activity relationship of (-) mammea A/BB derivatives against Leishmania amazonensis

Planta Medica ◽  
2008 ◽  
Vol 74 (09) ◽  
Author(s):  
MA Brenzan ◽  
CV Nakamura ◽  
BPD Filho ◽  
T Ueda-Nakamura ◽  
MCM Young ◽  
...  
Keyword(s):  
Structure Activity Relationship ◽  
Leishmania Amazonensis ◽  
Activity Relationship ◽  
Structure Activity ◽  
Relationship Of
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