Accumulation of halogenated aromatic hydrocarbons and activities of cytochrome P450 and glutathiones-transferase in CRABS (Eriocheir japonicus) from Japanese Rivers

1998 ◽  
Vol 17 (8) ◽  
pp. 1490-1498 ◽  
Author(s):  
Mayumi Ishizuka ◽  
Takanori Sakiyama ◽  
Hisato Iwata ◽  
Minoru Fukushima ◽  
Akio Kazusaka ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Aromatic Hydrocarbons ◽  
Halogenated Aromatic Hydrocarbons ◽  
Japanese Rivers ◽  
Eriocheir Japonicus

Biodegradation of Polycyclic Aromatic Hydrocarbons Using FungiNew Prospects toward Cytochrome P450 Engineering

2018 ◽  
pp. 417-445
Author(s):  
Ulises Conejo-Saucedo ◽  
Darío Rafael Olicón-Hernández ◽  
Haley Paula Stein ◽  
Jesús González-López ◽  
Elisabet Aranda
Keyword(s):  
Cytochrome P450 ◽  
Polycyclic Aromatic Hydrocarbons ◽  
Aromatic Hydrocarbons ◽  
Polycyclic Aromatic

The 2001 Veylien Henderson Award of the Society of Toxicology of Canada. Positive and negative transcriptional regulation of cytochromes P450 by polycyclic aromatic hydrocarbons

2003 ◽  
Vol 81 (1) ◽  
pp. 59-77 ◽  
Author(s):  
David S Riddick ◽  
Chunja Lee ◽  
Anahita Bhathena ◽  
Yoav E Timsit
Keyword(s):  
Growth Hormone ◽  
Transcriptional Regulation ◽  
Cytochrome P450 ◽  
Aromatic Hydrocarbon ◽  
Aromatic Hydrocarbons ◽  
Cytochromes P450 ◽  
Biological Significance ◽  
Male Rats ◽  
Cytochrome P450 1A1 ◽  
Aromatic Hydrocarbon Receptor

Most responses to aromatic hydrocarbons such as 3-methylcholanthrene (MC) and 2,3,7,8-tetrachlorodibenzo-p-dioxin are mediated by the aromatic hydrocarbon receptor (AHR). The AHR regulates induction of drug-metabolizing enzymes such as cytochrome P450 1A1. However, the expression of several genes of biological significance is decreased by these chemicals. We are examining the mechanisms by which aromatic hydrocarbons suppress constitutive hepatic cytochromes P450, especially the male-specific rat liver cytochrome P450 2C11 (CYP2C11), which is regulated by pulsatile growth hormone (GH) secretion. Aromatic hydrocarbons suppress CYP2C11 via a transcriptional mechanism both in vivo and in cultured hepatocytes, and the AHR appears to be involved; however, studies of protein–DNA interactions and reporter genes driven by the CYP2C11 5'-flanking region have not provided a definitive mechanism for this response. MC attenuates the ability of GH to stimulate hepatic CYP2C11 expression in hypophysectomized (hypx) male rats, and this prompted studies of effects of aromatic hydrocarbons on hepatic GH signaling pathways as a novel aspect of endocrine disruption. Our studies with hypx rats also suggest that the hepatic AHR protein is regulated by a pituitary factor(s). The goal of these molecular mechanistic studies is to improve our understanding of how environmental contaminants modulate the expression of genes coding for xenobiotic- and hormone-metabolizing enzymes.Key words: aromatic hydrocarbons, cytochrome P450, aromatic hydrocarbon receptor, growth hormone, transcriptional regulation.

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