scholarly journals Evaluation of gas chromatography with electrolytic conductivity detection and electron capture detection and use of negative chemical ionization GC-MS for the analysis of PCBs in effluents

1991 ◽  
Vol 10 (11) ◽  
pp. 1391-1398 ◽  
Author(s):  
John Greaves ◽  
Ellen Harvey ◽  
Robert J. Huggett
Keyword(s):  
Gas Chromatography ◽  
Electron Capture ◽  
Chemical Ionization ◽  
Electrolytic Conductivity ◽  
Electron Capture Detection ◽  
Negative Chemical Ionization ◽  
Conductivity Detection

Determination of Desaminosulfamethazine, Sulfamethazine, and N4-Acetylsulfamethazine by Gas Chromatography with Electron Capture Detection and Confirmation by Gas Chromatography-Chemical Ionization Mass Spectrometry

1987 ◽  
Vol 70 (3) ◽  
pp. 546-553
Author(s):  
Jean E Matusik ◽  
Greg C Guyer ◽  
Jaroslav N Geleta ◽  
Charlie J Barnes
Keyword(s):  
Mass Spectrometry ◽  
Gas Chromatography ◽  
Electron Capture ◽  
Chemical Ionization ◽  
Ionization Mass Spectrometry ◽  
Chemical Ionization Mass Spectrometry ◽  
Electron Capture Detection ◽  
Ionization Mass ◽  
Veal Calf

Abstract An electron capture gas chromatographic method for the determination of sulfamethazine was modified to separate and quantitate simultaneously sulfamethazine and 2 of its metabolites, N4-acetylsulfamethazine and desaminosulfamethazine. The modified method was applied to incurred residues in a veal calf depletion study and to incurred residues in swine tissues. With capillary column gas chromatography-positive ion chemical ionization mass spectrometry, confirmation of the identities of incurred desaminosulfamethazine, N4-acetylsulfamethazine, and sulfamethazine in tissues was obtained from a single injection.

scholarly journals Determination of blood lead by electron-capture negative chemical ionization gas chromatography-mass spectrometry

1996 ◽  
Vol 42 (2) ◽  
pp. 286-291 ◽  
Author(s):  
G S Baird ◽  
R L Fitzgerald ◽  
S K Aggarwal ◽  
D A Herold
Keyword(s):  
Mass Spectrometry ◽  
Gas Chromatography ◽  
Electron Capture ◽  
Isotope Dilution ◽  
Chemical Ionization ◽  
Gas Chromatography Mass Spectrometry ◽  
Pyrrolidine Dithiocarbamate ◽  
Negative Chemical Ionization ◽  
Chromatography Mass Spectrometry

Abstract An electron-capture negative chemical ionization (NCI) gas chromatography-mass spectrometry (GC-MS) method for determination of lead (Pb) in blood samples is described. Extraction of Pb from the sample does not involve hot digestion but is based on treatment at ambient temperature. The blood sample is supplemented with a known amount of internal standard (204Pb) for isotope dilution and is treated with concentrated nitric acid. After adjusting the pH to 7, the Pb is extracted into toluene as the pyrrolidine-dithiocarbamate chelate. Samples are then derivatized with 4- fluorophenylmagnesium bromide to form Pb(FC6H4)4. The use of NCI offers enhanced sensitivity (by 75-fold better than previously used electron ionization), gives good precision and accuracy, and has no observable memory effect. The isotope dilution GCoff methodology typically agreed within 2-3% of expected values for the College of American Pathologists blood Pb specimens and the National Institute of Standards and Technology Standard Reference Material 955a.

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