Chronic Exposure to Environmental DDT/DDE in 2 Species of Small Rodents: Measures of Contaminant Load, Immune Dysfunction, and Oxidative Stress

2021 ◽  
Author(s):  
Erica M. Molina ◽  
Andreas N. Kavazis ◽  
Mary T. Mendonça
Keyword(s):  
Oxidative Stress ◽  
Chronic Exposure ◽  
Immune Dysfunction ◽  
Small Rodents ◽  
And Oxidative Stress ◽  
Contaminant Load

scholarly journals Effect of chronic exposure to cadmium on serum lipid, lipoprotein and oxidative stress indices in male rats

2015 ◽  
Vol 8 (3) ◽  
pp. 151-154 ◽  
Author(s):  
Saeed Samarghandian ◽  
Mohsen Azimi-Nezhad ◽  
Mahmoud M. Shabestari ◽  
Farahzad Jabbari Azad ◽  
Tahereh Farkhondeh ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Drinking Water ◽  
Chronic Exposure ◽  
Plasma Lipid ◽  
Density Lipoprotein ◽  
Lipoprotein Cholesterol ◽  
Male Rats ◽  
Serum Triglycerides ◽  
Stress Indices ◽  
And Oxidative Stress

Abstract Cadmium (Cd) is an environmental toxic metal implicated in lipid abnormalities. The present study was designed to elucidate the possible association between chronic exposure to Cd concentration and alterations in plasma lipid, lipoprotein, and oxidative stress indices in rats. Sixteen male rats were assigned to 2 groups of 8 rats each (test and control). The Cd-exposed group obtained drinking water containing cadmium chloride (CdCl2) in the concentration of 2.0 mg Cd/L in drinking water for 3 months. At the end of the experimental period, blood samples were obtained to determine the changes of serum triglycerides (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), reduced glutathione (GSH), malondialdehyde (MDA) and also serum Cd contents. The results of the present study indicated that Cd administration significantly increased the serum levels of TG, TC, LDL-C, MDA and Cd with reduction in the HDL-C and GSH levels. In conclusion, evidence is presented that chronic exposure to low Cd concentration can adversely affect the lipid and lipoprotein profile via lipid peroxidation.

Immunosuppression and oxidative stress induced by acute and chronic exposure to cocaine in rat

2003 ◽  
Vol 3 (4) ◽  
pp. 581-592 ◽  
Author(s):  
Roberta Pacifici ◽  
Anna Ida Fiaschi ◽  
Lucia Micheli ◽  
Fabio Centini ◽  
Giorgio Giorgi ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Chronic Exposure ◽  
Acute And Chronic Exposure ◽  
And Oxidative Stress

scholarly journals Curcumin Mitigates Hypertension, Endothelial Dysfunction and Oxidative Stress in Rats with Chronic Exposure to Lead and Cadmium

2021 ◽  
Vol 253 (1) ◽  
pp. 69-76
Author(s):  
Akarachai Tubsakul ◽  
Weerapon Sangartit ◽  
Poungrat Pakdeechote ◽  
Veerapol Kukongviriyapan ◽  
Kwanjit Apaijit ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Endothelial Dysfunction ◽  
Chronic Exposure ◽  
Lead And Cadmium ◽  
And Oxidative Stress

scholarly journals Vitamin C Attenuates Oxidative Stress and Behavioral Abnormalities Triggered by Fipronil and Pyriproxyfen Insecticide Chronic Exposure on Zebrafish Juvenile

Antioxidants ◽  
2020 ◽  
Vol 9 (10) ◽  
pp. 944
Author(s):  
Madalina Andreea Robea ◽  
Roxana Jijie ◽  
Mircea Nicoara ◽  
Gabriel Plavan ◽  
Alin Stelian Ciobica ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Social Behavior ◽  
Vitamin C ◽  
Chronic Exposure ◽  
Protective Role ◽  
Autism Spectrum ◽  
Oxidative Stress Biomarkers ◽  
And Oxidative Stress ◽  
Vit C

Chronic exposure to synthetic insecticides in the early life of a child can lead to a series of disorders. Several causes as parental age, maternal smoking, birth complications, and exposure to toxins such as insecticides on childhood can lead to Autism spectrum disorder (ASD) occurrence. The aim of this study was to evaluate the potential protective role of vitamin C (Vit. C) from children’s supplements after 14 days chronic exposure to insecticide mixture fipronil (Fip) + pyriproxyfen (Pyr) on juvenile zebrafish for swimming performances, social behavior and oxidative stress associated with ASD model. Juvenile (14–17 mm) wild-type AB zebrafish (Danio rerio) (45 days) were exposed to relevant concentrations: vit. C (25 µg L−1), Fip (600 µg L−1/1.372 μM) + Pyr (600 µg L−1/1.89 μM), and [Fip (600 µg L−1/1.372 μM) + Pyr (600 µg L−1 /1.89 μM)] + vit. C (25 µg L−1). Our results showed that insecticides can disturb the social behavior of zebrafish during 14 days of the administration, decreased the swimming performances, and elevated the oxidative stress biomarkers of SOD (superoxide dismutase), GPx (glutathione peroxidase), and MDA (malondialdehyde). The vitamin C supplement significantly attenuated the neurotoxicity of insecticide mixture and oxidative stress. This study provides possible in vivo evidence to show that vitamin C supplements could attenuate oxidative stress and brain damage of fipronil and pyriproxyfen insecticide chronic exposure on zebrafish juvenile.

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