C-fin: A cultured frog tadpole tail fin biopsy approach for detection of thyroid hormone-disrupting chemicals

2010 ◽  
Vol 29 (2) ◽  
pp. 380-388 ◽  
Author(s):  
Ashley Hinther ◽  
Dominik Domanski ◽  
Saadia Vawda ◽  
Caren C. Helbing
Keyword(s):  
Thyroid Hormone ◽  
Tadpole Tail ◽  
Frog Tadpole

In Vitro Regression of Tadpole Tail by Thyroid Hormone. (Metamorphosis/tadpole tail regression/epidermis-mesenchyme interaction)

1984 ◽  
Vol 26 (4) ◽  
pp. 329-338 ◽  
Author(s):  
KAORU NIKI ◽  
KATSUTOSHI YOSHIZATO ◽  
HIDEO NAMIKI ◽  
SAKAE KIKUYAMA
Keyword(s):  
Thyroid Hormone ◽  
Tadpole Tail

scholarly journals Acetyl-L-carnitine suppresses thyroid hormone-induced and spontaneous anuran tadpole tail shortening

Hereditas ◽  
2013 ◽  
Vol 150 (1) ◽  
pp. 1-9
Author(s):  
Hideki Hanada ◽  
Hirotsugu Kobuchi ◽  
Masanao Yamamoto ◽  
Keiko Kashiwagi ◽  
Kenjiro Katsu ◽  
...  
Keyword(s):  
Thyroid Hormone ◽  
Tadpole Tail ◽  
Anuran Tadpole

Hormonal regulation of programmed cell death during amphibian metamorphosis

1994 ◽  
Vol 72 (11-12) ◽  
pp. 581-588 ◽  
Author(s):  
Jamshed R. Tata
Keyword(s):  
Cell Death ◽  
Thyroid Hormone ◽  
Programmed Cell Death ◽  
Hormonal Regulation ◽  
Hormone Receptors ◽  
Amphibian Metamorphosis ◽  
Early Genes ◽  
Tadpole Tail ◽  
Inducible Genes ◽  
Promote Cell Death

Extensive programmed cell death (PCD) is initiated at the onset of amphibian metamorphosis, resulting in 100% of cells dying in some larval tissues, as during total regression of tail and gills. All cell death during metamorphosis is under the control of thyroid hormone (TH), which can initiate the process precociously in whole tadpoles or in individual tissues in culture. The hormone prolactin (PRL), given exogenously, prevents natural and TH-induced metamorphosis. We have exploited this dual hormonal regulation in premetamorphic Xenopus tails in organ culture to identify and characterize early genes that are TH-induced and considered important for initiating cell death. Among the earliest genes activated by TH are those encoding the two thyroid hormone receptors TRα and TRβ. This autoinduction of TR genes is considered important since, in blocking this process, PRL also inhibited the expression of other TH-inducible genes and prevented cell death. The expression of early genes other than TR genes, which are known to promote cell death or survival, is also considered to be important for the initiation of PCD during amphibian metamorphosis. We are, therefore, working on the identification, characterization, and expression of members of the Xenopus bcl-2-like gene family, as well as other genes, such as nur-77 and ICE, which may act as early genes during tadpole tail regression.Key words: cell death, thyroid hormones, Xenopus, metamorphosis, gene expression.

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