Ecotoxicity of bisphenol S to Caenorhabditis elegans by prolonged exposure in comparison with bisphenol A

2018 ◽  
Vol 37 (10) ◽  
pp. 2560-2565 ◽  
Author(s):  
Dong Zhou
Keyword(s):  
Caenorhabditis Elegans ◽  
Bisphenol A ◽  
Prolonged Exposure ◽  
Bisphenol S

scholarly journals Binding of bisphenol A, bisphenol AF, and bisphenol S on the androgen receptor: Coregulator recruitment and stimulation of potential interaction sites

2017 ◽  
Vol 44 ◽  
pp. 287-302 ◽  
Author(s):  
Lalith Perera ◽  
Yin Li ◽  
Laurel A. Coons ◽  
Rene Houtman ◽  
Rinie van Beuningen ◽  
...  
Keyword(s):  
Androgen Receptor ◽  
Bisphenol A ◽  
Potential Interaction ◽  
Bisphenol S ◽  
Interaction Sites ◽  
Bisphenol Af ◽  
Stimulation Of

Bisphenol A, Bisphenol AF, and Bisphenol S - A comparison of pre- and postnatal endpoints

2018 ◽  
Vol 80 ◽  
pp. 32
Author(s):  
Vicki L. Sutherland ◽  
Barry McIntyre ◽  
Helen Cunny ◽  
Suramya Waidyanatha ◽  
Jui-Hua Hsieh ◽  
...  
Keyword(s):  
Bisphenol A ◽  
Bisphenol S ◽  
Bisphenol Af

High Levels of Bisphenol A and Bisphenol S in Brazilian Thermal Paper Receipts and Estimation of Daily Exposure

2015 ◽  
Vol 78 (18) ◽  
pp. 1181-1188 ◽  
Author(s):  
Bruno Alves Rocha ◽  
Lara Ferreira Azevedo ◽  
Matheus Gallimberti ◽  
Andres Dobal Campiglia ◽  
Fernando Barbosa
Keyword(s):  
Bisphenol A ◽  
Bisphenol S ◽  
Daily Exposure ◽  
Thermal Paper

scholarly journals Bisphenol S and bisphenol F are less disruptive to cardiac electrophysiology and potentially safer for use in medical products, as compared to bisphenol A

2021 ◽  
Author(s):  
Tomas Prudencio ◽  
Luther Swift ◽  
Devon Guerrelli ◽  
Blake Cooper ◽  
Marissa Reilly ◽  
...  
Keyword(s):  
Bisphenol A ◽  
Safety Profile ◽  
Intracellular Signaling ◽  
Cardiac Electrophysiology ◽  
Field Potential ◽  
Production Volume ◽  
Bisphenol S ◽  
Bisphenol F ◽  
Bisphenol Analogues ◽  
Whole Heart

ABSTRACTBackgroundBisphenol A (BPA) is a high-production volume chemical that is commonly used to manufacture consumer and medical-grade plastic products. Due to its ubiquity, the general population can incur daily environmental exposure to BPA, while heightened BPA exposure has been reported in intensive care patients and industrial workers. Due to health concerns, structural analogues are being explored as replacements for BPA.ObjectiveThis study aimed to examine the direct nongenomic effects of BPA on cardiac electrophysiology and compare its safety profile to recently developed alternatives, including BPS (bisphenol S) and BPF (bisphenol F).MethodsWhole-cell voltage-clamp recordings were performed on cell lines transfected with Nav1.5, hERG, or Cav1.2. Results of single channel experiments were validated by conducting electrophysiology studies on human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CM) and intact, whole heart preparations.ResultsOf the chemicals tested, BPA was the most potent inhibitor of both fast (INa-P) and late (INa-L) sodium channel (IC50 = 55.3 and 23.6 μM, respectively), L-type calcium channel (IC50 = 30.8 μM) and hERG channel current (IC50 = 127 μM). The inhibitory effects of BPA and BPF on L-type calcium channels were supported by microelectrode array recordings, which revealed shortening of the extracellular field potential (akin to QT interval). Further, BPA and BPF exposure impaired atrioventricular conduction in intact, whole heart experiments. BPS did not alter any of the cardiac electrophysiology parameters tested.DiscussionResults of this study demonstrate that BPA and BPF exert an immediate inhibitory effect on cardiac ion channels, and that BPS may be a safer alternative. Intracellular signaling or genomic effects of bisphenol analogues were not investigated; therefore, additional mechanistic studies are necessary to fully elucidate the safety profile of bisphenol analogues on the heart.

Bisphenol A and its analogs bisphenol B, bisphenol F, and bisphenol S: Comparative in vitro and in vivo studies on the sperms and testicular tissues of rats

Chemosphere ◽  
2018 ◽  
Vol 209 ◽  
pp. 508-516 ◽  
Author(s):  
Asad Ullah ◽  
Madeeha Pirzada ◽  
Sarwat Jahan ◽  
Hizb Ullah ◽  
Ghazala Shaheen ◽  
...  
Keyword(s):  
Bisphenol A ◽  
In Vivo Studies ◽  
Bisphenol S ◽  
Bisphenol F

scholarly journals Bisphenol S in Food Causes Hormonal and Obesogenic Effects Comparable to or Worse than Bisphenol A: A Literature Review

Nutrients ◽  
2020 ◽  
Vol 12 (2) ◽  
pp. 532 ◽  
Author(s):  
Michael Thoene ◽  
Ewa Dzika ◽  
Slawomir Gonkowski ◽  
Joanna Wojtkiewicz
Keyword(s):  
Bisphenol A ◽  
Food Packaging ◽  
Metabolic Disorders ◽  
Literature Survey ◽  
Breast Cancers ◽  
Bisphenol S ◽  
Free Products ◽  
Strong Argument ◽  
The Public ◽  
Bisphenol Analogues

In recent years, bisphenol analogues such as bisphenol S (BPS) have come to replace bisphenol A in food packaging and food containers, since bisphenol A (BPA) has been shown to leach into food and water, causing numerous negative health effects. Unfortunately, little or no research was done to determine the safety of these BPA-free products before they were marketed to the public as a healthier alternative. The latest studies have shown that some of these bisphenol analogues may be even more harmful than the original BPA in some situations. This article used a literature survey to investigate the bisphenol analogue BPS and compare it to BPA and other analogues with regards to increased obesity, metabolic disorders, cancer, and reproductive defects; among others. It was found that BPS works via different pathways than does BPA while causing equivalent obesogenic effects, such as activating preadipocytes, and that BPS was correlated with metabolic disorders, such as gestational diabetes, that BPA was not correlated with. BPS was also shown to be more toxic to the reproductive system than BPA and was shown to hormonally promote certain breast cancers at the same rate as BPA. Therefore, a strong argument may be made to regulate BPS in exactly the same manner as BPA.

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