A computational approach predicting CYP450 metabolism and estrogenic activity of an endocrine disrupting compound (PCB-30)

2014 ◽  
Vol 33 (7) ◽  
pp. 1615-1623 ◽  
Author(s):  
Jason B. Harris ◽  
Melanie L. Eldridge ◽  
Gary Sayler ◽  
Fu-Min Menn ◽  
Alice C. Layton ◽  
...  
Keyword(s):  
Estrogenic Activity ◽  
Computational Approach ◽  
Endocrine Disrupting Compound ◽  
Endocrine Disrupting

High efficiency removal and recovery of an endocrine disrupting compound–bisphenol AF from wastewaters

2013 ◽  
Vol 116 ◽  
pp. 145-153 ◽  
Author(s):  
Lei Zhang ◽  
Junna Lv ◽  
Tianci Xu ◽  
Lijun Yang ◽  
Xiaoqing Jiang ◽  
...  
Keyword(s):  
High Efficiency ◽  
Endocrine Disrupting Compound ◽  
Endocrine Disrupting ◽  
Bisphenol Af ◽  
Removal And Recovery

Nanocomposite Membrane-Based Photocatalytic Reactor for Degradation of Endocrine-Disrupting Compound in Water

2018 ◽  
pp. 403-439
Author(s):  
Hazlini Dzinun ◽  
Mohd Hafiz Dzarfan Othman ◽  
A. F. Ismail ◽  
Mohd Hafiz Puteh ◽  
Mukhlis A. Rahman ◽  
...  
Keyword(s):  
Nanocomposite Membrane ◽  
Photocatalytic Reactor ◽  
Endocrine Disrupting Compound ◽  
Endocrine Disrupting

scholarly journals Facile Synthesis of Porous ZnO Nanoparticles Efficient for Photocatalytic Degradation of Biomass-Derived Bisphenol A Under Simulated Sunlight Irradiation

2021 ◽  
Vol 8 ◽  
Author(s):  
Yujie Wang ◽  
Kang Hu ◽  
Zhiyu Yang ◽  
Chenlu Ye ◽  
Xin Li ◽  
...  
Keyword(s):  
Bisphenol A ◽  
Photocatalytic Degradation ◽  
Inorganic Ions ◽  
Endocrine Disrupting Compounds ◽  
Degradation Process ◽  
Sunlight Irradiation ◽  
Calcination Temperatures ◽  
Endocrine Disrupting Compound ◽  
Endocrine Disrupting ◽  
Photocatalytic Removal

Bisphenol A (BPA) produced from biomass is a typical endocrine disrupting compound that is carcinogenic and genotoxic and can be accumulated in water due to its extensive use and difficult degradation. In this study, the porous ZnO photocatalyst with core-shell structure and large surface area was successfully developed for the efficient photocatalytic degradation of BPA. The various effects of calcination temperatures, BPA concentrations, ZnO dosages, pH and inorganic ions on the degradation performance were systemically studied. The results showed that 99% degradation of BPA was achieved in 1 h using the porous ZnO calcined at 550°C under the conditions of 30 mg/L BPA, 1 g/L ZnO, and pH of 6.5. Besides, the inhibition effects of anions for the photocatalytic removal of BPA decreased in the order of H2PO4- > HCO3- > SO42- > Cl−, while the cations K+, Ca2+, and Na+ had little effect on the photocatalytic degradation of BPA. The results of scavenging experiments showed that h+, ·O2-, and e− played the key role in the photocatalytic degradation process. Finally, the main pathways of BPA degradation were proposed based on ten intermediates found in the degradation process. This work may provide a good guideline to degrade various endocrine disrupting compounds in wastewater treatment.

Effect on JNK/MAPK Pathways in the Damage of Rat Testicle Sertoli Cells Induced by DBP

2013 ◽  
Vol 864-867 ◽  
pp. 797-800
Author(s):  
Huan Li ◽  
Yi Zhang ◽  
Peng Min Wang ◽  
Jing Hong Yu
Keyword(s):  
Sertoli Cells ◽  
Food Packaging ◽  
Dibutyl Phthalate ◽  
Signal Transduction Pathway ◽  
Dose Effect ◽  
Rt Pcr ◽  
Mapk Pathways ◽  
Endocrine Disrupting Compound ◽  
Endocrine Disrupting ◽  
Vitro Test

Dibutyl phthalate (DBP), an accepted environmental endocrine disrupting compound, which has anti-androgenic effects,is widely used in many industries such as plastics, pharmaceuticals, plastic food packaging materials. This article intends to study the effect on JNK/MAPK pathways in the damage of rat testicle sertoli cells induced by DBP via vitro test. Testicular sertoli cells of rates were incubated by medium containing DBP in different concentrations (0μg/ml,1μg/ml,10μg/ml, 100μg/ml). after culturing for 24 hours the expression of vimentin was detected by immunofluorescence; the expression of vimentin mRNA detected by RT-PCR; Western blot analyzed the expression of related protein of JNK/MAPK pathways in sertoli cells. The results showed that vimentin highly express in sertoli cells and gradually decrease with the increase of poisonous doses. The mRNA expression of vimentin in each exposure group has a downtrend with the increase of does. The total protein of JNK and P-JNK protein increased gradually in a dose effect manner. These results suggested that DBP can decrease the expression of vimentin mRNA, the decrease of which was regulated by JNK/MAPK signal transduction pathway that activated by DBP, and then induced the apoptosis of Sertoli cell.

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