Protective and antioxidant role of selenium on arsenic trioxide-induced oxidative stress and genotoxicity in the fish hepatoma cell line PLHC-1

2012 ◽  
Vol 31 (12) ◽  
pp. 2861-2869 ◽  
Author(s):  
Vellaisamy Selvaraj ◽  
Mindy Yeager-Armstead ◽  
Elizabeth Murray
Keyword(s):  
Oxidative Stress ◽  
Cell Line ◽  
Arsenic Trioxide ◽  
Hepatoma Cell ◽  
Hepatoma Cell Line

scholarly journals Increased Cytotoxicity of Carbon Tetrachloride in a Human Hepatoma Cell Line Overexpressing Cytochrome P450 2E1

2002 ◽  
Vol 30 (4) ◽  
pp. 400-405 ◽  
Author(s):  
S Takahashi ◽  
T Takahashi ◽  
S Mizobuchi ◽  
M Matsumi ◽  
K Morita ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Cytochrome P450 ◽  
Carbon Tetrachloride ◽  
Cell Line ◽  
Hepatoma Cell ◽  
Mrna Level ◽  
Hepatoma Cell Line ◽  
Cytochrome P450 2E1 ◽  
Hsp70 Mrna ◽  
Potential Marker

Cytotoxic free radicals generated during the metabolism of carbon tetrachloride by cytochrome P450 2E1 (CYP2E1) are thought to cause hepatotoxicity. Here, the cytotoxic effects of carbon tetrachloride in a liver cell line expressing CYP2E1 (HLE/2E1) are compared with those in the mother cell line (HLE). The effects of carbon tetrachloride on the gene expression of HSP70, a potential marker of oxidative stress, were also examined. The viability of HLE/2E1 cells after exposure to carbon tetrachloride was significantly decreased compared with that of HLE cells. Northern blot analysis revealed that the HSP70 mRNA level was significantly increased after carbon tetrachloride treatment in both cell lines, while the magnitude of its increase was much greater in HLE/2E1 cells than in HLE cells. These results suggest that the oxidative stress induced by CYP2E1 plays an important role in the increase in cytotoxicity of carbon tetrachloride in CYP2E1-overexpressing cells.

Role of ATP7B in biliary copper excretion in a human hepatoma cell line and normal rat hepatocytes

2000 ◽  
Vol 118 (5) ◽  
pp. 921-928 ◽  
Author(s):  
Masaru Harada ◽  
Shotaro Sakisaka ◽  
Kunihiko Terada ◽  
Rina Kimura ◽  
Takumi Kawaguchi ◽  
...  
Keyword(s):  
Cell Line ◽  
Hepatoma Cell ◽  
Rat Hepatocytes ◽  
Hepatoma Cell Line ◽  
Human Hepatoma ◽  
Human Hepatoma Cell ◽  
Copper Excretion ◽  
Human Hepatoma Cell Line ◽  
Normal Rat

scholarly journals Role of MAP kinases and their cross-talk in TGF-β1-induced apoptosis in FaO rat hepatoma cell line

Hepatology ◽  
2002 ◽  
Vol 35 (6) ◽  
pp. 1360-1371 ◽  
Author(s):  
Hyun-Jin Park ◽  
Byung-Chul Kim ◽  
Seong-Jin Kim ◽  
Kyeong Sook Choi
Keyword(s):  
Cell Line ◽  
Cross Talk ◽  
Map Kinases ◽  
Hepatoma Cell ◽  
Hepatoma Cell Line ◽  
Induced Apoptosis ◽  
Rat Hepatoma Cell Line ◽  
Tgf Β1 ◽  
Rat Hepatoma
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