scholarly journals The neural correlates of a central coherence task in young women with anorexia nervosa

2021 ◽  
Author(s):  
Monica Leslie ◽  
Daniel Halls ◽  
Jenni Leppanen ◽  
Felicity Sedgewick ◽  
Katie Lang ◽  
...  
Keyword(s):  
Anorexia Nervosa ◽  
Young Women ◽  
Neural Correlates ◽  
Central Coherence

scholarly journals Neural Correlates of Theory of Mind Are Preserved in Young Women With Anorexia Nervosa

2020 ◽  
Vol 11 ◽  
Author(s):  
Monica Leslie ◽  
Daniel Halls ◽  
Jenni Leppanen ◽  
Felicity Sedgewick ◽  
Katherine Smith ◽  
...  
Keyword(s):  
Anorexia Nervosa ◽  
Prefrontal Cortex ◽  
Theory Of Mind ◽  
Social Interactions ◽  
Young Women ◽  
Inferior Frontal Gyrus ◽  
Reliability And Validity ◽  
Neural Correlates ◽  
Neural Activation ◽  
Neural Basis

People with anorexia nervosa (AN) commonly exhibit social difficulties, which may be related to problems with understanding the perspectives of others, commonly known as Theory of Mind (ToM) processing. However, there is a dearth of literature investigating the neural basis of these differences in ToM and at what age they emerge. This study aimed to test for differences in the neural correlates of ToM processes in young women with AN, and young women weight-restored (WR) from AN, as compared to healthy control participants (HC). Based on previous findings in AN, we hypothesized that young women with current or prior AN, as compared to HCs, would exhibit a reduced neural response in the medial prefrontal cortex (mPFC), the inferior frontal gyrus, and the temporo-parietal junction (TPJ) whilst completing a ToM task. We recruited 73 young women with AN, 45 WR young women, and 70 young women without a history of AN to take part in the current study. Whilst undergoing a functional magnetic resonance imaging (fMRI) scan, participants completed the Frith-Happé task, which is a commonly used measure of ToM with demonstrated reliability and validity in adult populations. In this task, participants viewed the movements of triangles, which depicted either action movements, simple interactions, or complex social interactions. Viewing trials with more complex social interactions in the Frith-Happé task was associated with increased brain activation in regions including the right TPJ, the bilateral mPFC, the cerebellum, and the dorsolateral prefrontal cortex. There were no group differences in neural activation in response to the ToM contrast. Overall, these results suggest that the neural basis of spontaneous mentalizing is preserved in most young women with AN.

scholarly journals Corrigendum: Neural Correlates of Theory of Mind Are Preserved in Young Women With Anorexia Nervosa

2020 ◽  
Vol 11 ◽  
Author(s):  
Monica Leslie ◽  
Daniel Halls ◽  
Jenni Leppanen ◽  
Felicity Sedgewick ◽  
Katherine Smith ◽  
...  
Keyword(s):  
Anorexia Nervosa ◽  
Theory Of Mind ◽  
Young Women ◽  
Neural Correlates

Executive functioning and central coherence in anorexia nervosa: Pilot investigation of a neurocognitive endophenotype

2018 ◽  
Vol 26 (5) ◽  
pp. 489-498 ◽  
Author(s):  
Melanie Brown ◽  
Katharine L. Loeb ◽  
Robert E. McGrath ◽  
Lana Tiersky ◽  
Nancy Zucker ◽  
...  
Keyword(s):  
Anorexia Nervosa ◽  
Executive Functioning ◽  
Central Coherence ◽  
Pilot Investigation

scholarly journals Incidence of anorexia nervosa in young people in the UK and Ireland: a national surveillance study

BMJ Open ◽  
2019 ◽  
Vol 9 (10) ◽  
pp. e027339 ◽  
Author(s):  
Hristina Petkova ◽  
Mima Simic ◽  
Dasha Nicholls ◽  
Tamsin Ford ◽  
A Matthew Prina ◽  
...  
Keyword(s):  
Mental Health ◽  
Anorexia Nervosa ◽  
Mental Health Services ◽  
Young People ◽  
Health Services ◽  
Young Women ◽  
Adolescent Mental Health ◽  
Child And Adolescent ◽  
Surveillance Study ◽  
The Uk

ObjectivesThis study aimed to estimate the incidence of DSM5 anorexia nervosa in young people in contact with child and adolescent mental health services in the UK and Ireland.DesignObservational, surveillance study, using the Child and Adolescent Psychiatry Surveillance System, involving monthly reporting by child and adolescent psychiatrists between 1st February 2015 and 30th September 2015.SettingThe study was based in the UK and Ireland.ParticipantsClinician-reported data on young people aged 8–17 in contact with child and adolescent mental health services for a first episode of anorexia nervosa.Main outcome measuresAnnual incidence rates (IRs) estimated as confirmed new cases per 100 000 population at risk.Results305 incident cases of anorexia nervosa were reported over the 8-month surveillance period and assessed as eligible for inclusion. The majority were young women (91%), from England (70%) and of white ethnicity (92%). Mean age was 14.6 years (±1.66) and mean percentage of median expected body mass index for age and sex was 83.23% (±10.99%). The overall IR, adjusted for missing data, was estimated to be 13.68 per 100 000 population (95% CI 12.88 to 14.52), with rates of 25.66 (95% CI 24.09 to 27.30) for young women and 2.28 (95% CI 1.84 to 2.79) for young men. Incidence increased steadily with age, peaking at 15 (57.77, 95% CI 50.41 to 65.90) for young women and 16 (5.14, 95% CI 3.20 to 7.83) for young men. Comparison with earlier estimates suggests IRs for children aged 12 and under have increased over the last 10 years.ConclusionThese results provide new estimates of the incidence of anorexia nervosa in young people. Service providers and commissioners should consider evidence to suggest an increase in incidence in younger children.Trial registration numberISRCTN12676087.

S75. Maladaptive Food Choice and Neural Correlates Persist After Weight Restoration in Anorexia Nervosa

2019 ◽  
Vol 85 (10) ◽  
pp. S326
Author(s):  
Joanna Steinglass ◽  
Karin Foerde ◽  
Teresa Rufin ◽  
B. Timothy Walsh ◽  
Daphna Shohamy
Keyword(s):  
Anorexia Nervosa ◽  
Food Choice ◽  
Neural Correlates ◽  
Weight Restoration

Differences in set-shifting and central coherence across anorexia nervosa subtypes in children and adolescents

2018 ◽  
Vol 26 (5) ◽  
pp. 499-507 ◽  
Author(s):  
Laura Herbrich ◽  
Viola Kappel ◽  
Betteke Maria van Noort ◽  
Sibylle Winter
Keyword(s):  
Anorexia Nervosa ◽  
Children And Adolescents ◽  
Central Coherence ◽  
Set Shifting

scholarly journals Specific Effects of Anorexia Nervosa and Obesity on Bone Mineral Density and Bone Turnover in Young Women

2019 ◽  
Vol 105 (4) ◽  
pp. e1536-e1548 ◽  
Author(s):  
Laurent Maïmoun ◽  
Patrick Garnero ◽  
Thibault Mura ◽  
David Nocca ◽  
Patrick Lefebvre ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Anorexia Nervosa ◽  
Bone Formation ◽  
Bone Turnover ◽  
Young Women ◽  
Bone Turnover Markers ◽  
The Other ◽  
Mineral Density ◽  
Turnover Markers ◽  
Markers Of Bone Formation

Abstract Objective The threefold aim was to (1) compare areal bone mineral density (aBMD), bone turnover markers, and periostin levels in young women with either anorexia nervosa (AN) or obesity (OB) and controls (CON); (2) model the profiles according to age; and (3) determine the parameters associated with aBMD. Subjects and Methods One hundred and fifty-two young women with ages ranging from 16.0 to 27.0 years were subdivided into 3 groups (AN, OB, CON). The CON group was age-matched by ±6 months. aBMD, bone turnover markers, and periostin levels were evaluated. Results aBMD modeling showed that hip aBMD was higher in OB than in the other 2 groups from 19 years, and AN presented lower values than CON from 21 years. aBMD at the lumbar spine was higher in older OB and CON women, starting from 20 to 22 years, but in AN the difference with the other 2 groups increased with age. Periostin levels were lower in OB than in AN or CON, but no variation with age was observed. Compared with controls, OB and AN presented similarly lower markers of bone formation, although markers of bone resorption were lower in OB and higher in AN. A modeling approach showed that markers of bone formation and resorption were lower in older than in younger CON, whereas the values of these bone markers remained relatively constant in AN and OB. In all groups, lean body mass (LBM) was the parameter most positively correlated with aBMD. Conclusion This study demonstrated that weight extremes (AN or OB) influence aBMD, bone remodeling and periostin profiles. Moreover, factors related to aBMD were specific to each condition, but LBM was the parameter most consistently associated with aBMD.

scholarly journals Changes in appetite-regulating hormones following food intake are associated with changes in reported appetite and a measure of hedonic eating in girls and young women with anorexia nervosa

2020 ◽  
Vol 113 ◽  
pp. 104556 ◽  
Author(s):  
Christopher Mancuso ◽  
Alyssa Izquierdo ◽  
Meghan Slattery ◽  
Kendra R. Becker ◽  
Franziska Plessow ◽  
...  
Keyword(s):  
Anorexia Nervosa ◽  
Food Intake ◽  
Young Women

Depression influences the EDI scores in anorexia nervosa patients

2003 ◽  
Vol 18 (3) ◽  
pp. 119-123 ◽  
Author(s):  
Chantal Bizeul ◽  
Jean Marcel Brun ◽  
Daniel Rigaud
Keyword(s):  
Anorexia Nervosa ◽  
Depressive Symptoms ◽  
Major Depression ◽  
Young Women ◽  
Interpersonal Relations ◽  
Severe Depression ◽  
Body Image Dissatisfaction ◽  
Control Group ◽  
Healthy Controls ◽  
Severity Of Depression

AbstractAimTo study the influence of the severity of depression on the eating disorder’s inventory (EDI) scores in anorexia nervosa (AN) patients.MethodsWe compared by variance analysis the EDI scores from three groups of AN patients: 55 patients having a major depression (as assessed by a Beck’s depression inventory (BDI) ≥ 16); 77 patients having a less severe depression (BDI < 16); 32 patients with mild or non-existent depression (BDI ≤ 7) and the EDI scores from a control group of 29 French healthy young women.ResultsHigher EDI scores were elicited in the more severely depressed AN patients than in the less- or non-depressed AN patients (P < 0.01). In non-depressed AN patients, none of the scores was different from those of the control group. This was particularly true for the scores “Slimness wish”, “bulimia”, “body image dissatisfaction”, “perfectionism” and “fear of maturity”. The non-depressed restrictive AN patients had no score which differ from healthy controls.DiscussionsThe present results suggested that the EDI scores are clearly influenced by the severity of depression. Among the psychopathological and behavioural traits assessed with the EDI, only a few were not related to depressive symptoms: “feeling of inefficiency” and “distrust in interpersonal relations”.

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