scholarly journals Drug Resistant Epilepsy and the hypothesis of intrinsic severity: What about the High‐Frequency Oscillations?

2021 ◽  
Author(s):  
Cesar E. Santana‐Gomez ◽  
Jerome Engel ◽  
Richard Staba
Keyword(s):  
High Frequency ◽  
Drug Resistant ◽  
High Frequency Oscillations ◽  
Drug Resistant Epilepsy

Effects of a stable concentration of propofol on interictal high-frequency oscillations in drug-resistant epilepsy

2021 ◽  
Vol 23 (2) ◽  
pp. 299-312
Author(s):  
Taku Inada ◽  
Katsuya Kobayashi ◽  
Takayuki Kikuchi ◽  
Masao Matsuhashi ◽  
Riki Matsumoto ◽  
...  
Keyword(s):  
High Frequency ◽  
Drug Resistant ◽  
High Frequency Oscillations ◽  
Drug Resistant Epilepsy

Epileptogenic high-frequency oscillations skip the motor area in children with multilobar drug-resistant epilepsy

2017 ◽  
Vol 128 (7) ◽  
pp. 1197-1205 ◽  
Author(s):  
Yasushi Iimura ◽  
Kevin Jones ◽  
Kyoko Hattori ◽  
Yushi Okazawa ◽  
Atsuko Noda ◽  
...  
Keyword(s):  
High Frequency ◽  
Motor Area ◽  
Drug Resistant ◽  
High Frequency Oscillations ◽  
Drug Resistant Epilepsy

scholarly journals High-frequency oscillations in scalp EEG mirror seizure frequency in pediatric focal epilepsy

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Ece Boran ◽  
Johannes Sarnthein ◽  
Niklaus Krayenbühl ◽  
Georgia Ramantani ◽  
Tommaso Fedele
Keyword(s):  
Seizure Frequency ◽  
Epilepsy Surgery ◽  
High Frequency ◽  
Focal Epilepsy ◽  
Low Noise ◽  
Drug Resistant ◽  
Scalp Eeg ◽  
High Frequency Oscillations ◽  
Custom Made ◽  
Active Epilepsy

Abstract High-frequency oscillations (HFO) are promising EEG biomarkers of epileptogenicity. While the evidence supporting their significance derives mainly from invasive recordings, recent studies have extended these observations to HFO recorded in the widely accessible scalp EEG. Here, we investigated whether scalp HFO in drug-resistant focal epilepsy correspond to epilepsy severity and how they are affected by surgical therapy. In eleven children with drug-resistant focal epilepsy that underwent epilepsy surgery, we prospectively recorded pre- and postsurgical scalp EEG with a custom-made low-noise amplifier (LNA). In four of these children, we also recorded intraoperative electrocorticography (ECoG). To detect clinically relevant HFO, we applied a previously validated automated detector. Scalp HFO rates showed a significant positive correlation with seizure frequency (R2 = 0.80, p < 0.001). Overall, scalp HFO rates were higher in patients with active epilepsy (19 recordings, p = 0.0066, PPV = 86%, NPV = 80%, accuracy = 84% CI [62% 94%]) and decreased following successful epilepsy surgery. The location of the highest HFO rates in scalp EEG matched the location of the highest HFO rates in ECoG. This study is the first step towards using non-invasively recorded scalp HFO to monitor disease severity in patients affected by epilepsy.

scholarly journals Periodic discharges with high frequency oscillations recorded from a cerebellar gangliocytoma in an epileptic infant

2021 ◽  
Vol 12 ◽  
pp. 98
Author(s):  
Nobutaka Mukae ◽  
Takato Morioka ◽  
Michiko Torio ◽  
Yasunari Sakai ◽  
Takafumi Shimogawa ◽  
...  
Keyword(s):  
High Frequency ◽  
Male Infant ◽  
Subtotal Resection ◽  
Supportive Evidence ◽  
Periodic Discharges ◽  
High Frequency Oscillations ◽  
Depth Electrodes ◽  
Japanese Male ◽  
Old Japanese ◽  
Drug Resistant Epilepsy

Background: Subcortical epilepsies associated with developmental tumors in the cerebellum are rarely experienced. As supportive evidence of the intrinsic epileptogenicity of cerebellar tumors, previous electroencephalogram (EEG) studies with intratumoral depth electrodes demonstrated epileptiform or ictal discharges. Recent studies have demonstrated that high frequency oscillations (HFOs) can be regarded as a new biomarker of epileptogenesis and ictogenesis; however, there are few evidence about HFOs in cases of epilepsy associated with cerebellar tumors. Case Description: A 6-month-old Japanese male infant presented to our hospital with drug resistant epilepsy. We underwent subtotal resection of a cerebellar gangliocytoma and obtained good seizure outcomes. Intraoperative EEG in the tumor depicted HFOs in the form of ripples, riding on periodic discharges. Conclusion: Our findings provide further supportive evidence for the intrinsic epileptogenicity of cerebellar tumors.

scholarly journals High-frequency oscillations, extent of surgical resection, and surgical outcome in drug-resistant focal epilepsy

Epilepsia ◽  
2013 ◽  
Vol 54 (5) ◽  
pp. 848-857 ◽  
Author(s):  
Claire Haegelen ◽  
Piero Perucca ◽  
Claude-Edouard Châtillon ◽  
Luciana Andrade-Valença ◽  
Rina Zelmann ◽  
...  
Keyword(s):  
Surgical Resection ◽  
Surgical Outcome ◽  
High Frequency ◽  
Focal Epilepsy ◽  
Drug Resistant ◽  
High Frequency Oscillations ◽  
Extent Of Surgical Resection

Deep brain stimulation for the treatment of drug-refractory epilepsy in a patient with a hypothalamic hamartoma

2011 ◽  
Vol 30 (2) ◽  
pp. E4 ◽  
Author(s):  
Carlo Efisio Marras ◽  
Michele Rizzi ◽  
Flavio Villani ◽  
Giuseppe Messina ◽  
Francesco Deleo ◽  
...  
Keyword(s):  
Seizure Frequency ◽  
High Frequency ◽  
Complex Partial Seizure ◽  
High Frequency Stimulation ◽  
Hypothalamic Hamartoma ◽  
Drug Resistant ◽  
Neurophysiological Studies ◽  
Frequency Stimulation ◽  
Drug Resistant Epilepsy ◽  
Deep Brain

Hypothalamic hamartomas (HHs) are developmental malformations associated with a range of neurological problems, including intractable seizures. There is increasing evidence of the epileptogenicity of the hamartoma and of the inhomogeneous distribution of the epileptic abnormalities within the malformation. The management strategy for treatment and results differ according to the insertion plane and the extension of the malformation into the hypothalamus. Cases characterized by extensive involvement of the hypothalamus are particularly challenging. The authors describe the case of a patient with drug-resistant epilepsy and a large hypothalamic hamartoma with an extensive area of attachment. The patient underwent implantation of 2 deep brain electrodes. The intraoperative recording showed a synchronous interictal epileptic discharge in the left temporal lobe and on the left side of the lesion. The patient was treated with chronic high-frequency stimulation. No side effects due to the stimulation were reported. At 18 months' follow-up, a reduction in complex partial seizure frequency was reported, but no significant reduction in overall seizure frequency was noticed (p = 0.14, t-test). The authors report on neurophysiological studies of the relationship between HH and epilepsy, and also discuss the literature on chronic high-frequency stimulation, including its rationale and the results of chronic stimulation of various targets for the treatment of drug-resistant epilepsy due to HH.

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