scholarly journals The opioid antagonist naltrexone decreases seizure‐like activity in genetic and chemically‐induced epilepsy models

2021 ◽  
Author(s):  
Morgan L. Sturgeon ◽  
Rachel Langton ◽  
Shaunik Sharma ◽  
Robert A. Cornell ◽  
Joseph Glykys ◽  
...  
Keyword(s):  
Opioid Antagonist ◽  
Chemically Induced ◽  
Epilepsy Models

scholarly journals Antinociceptive Effect of the Essential Oil Obtained from the Leaves ofCroton cordiifoliusBaill. (Euphorbiaceae) in Mice

2015 ◽  
Vol 2015 ◽  
pp. 1-7 ◽  
Author(s):  
Lenise de Morais Nogueira ◽  
Monalisa Ribeiro da Silva ◽  
Simone Maria dos Santos ◽  
Julianna Ferreira Cavalcanti de Albuquerque ◽  
Igor Cavalcanti Ferraz ◽  
...  
Keyword(s):  
Acetic Acid ◽  
Essential Oil ◽  
Antinociceptive Effect ◽  
Antinociceptive Activity ◽  
Opioid Antagonist ◽  
Gas Chromatography Mass Spectrometry ◽  
Semiarid Region ◽  
Ethnobotanical Survey ◽  
Chemically Induced ◽  
Central Nervous Systems

Croton cordiifoliusBaill. is a shrub known as “quebra-faca” and is used to treat inflammation, pain, wounds, and gastrointestinal disturbances in the semiarid region in the northeast of Brazil. In an ethnobotanical survey in the state of Pernambuco, “quebra-faca” use was cited in 33% of the interviews. Thus, we decided to evaluate the antinociceptive effects of the essential oil fromC. cordiifolius(CcEO). Chemical analysis by gas chromatography-mass spectrometry revealed 1,8-cineole (25.09%) andα-phellandrene (15.43%) as major constituents. Antinociceptive activity was evaluated using murine models of chemically induced pain (writhing induced by acetic acid, formalin, capsaicin, and glutamate tests). Opioid and central nervous systems (CNS) involvement were also investigated. Regarding antinociceptive activity, CcEO (50 and 100 mg/kg) reduced the number of writhing responses induced by acetic acid and decreased the licking times in both phases of the formalin test. CcEO also was evaluated in capsaicin- and glutamate-induced nociception. While no effect was observed in the capsaicin test, CcEO (100 mg/kg) was effective in the glutamate test. Naloxone, an opioid antagonist, did not affect the antinociceptive activity of CcEO in writhing test. In conclusion, the antinociceptive effect of CcEO could be explained, at least in part, by inhibition of the glutamatergic system.

Biological and Surface Properties of C-Type Virus Particles Produced by Novikoff Ascites Hepatoma Cells

1977 ◽  
Vol 35 ◽  
pp. 388-389
Author(s):  
D.C. Hixson ◽  
J.C. Chan ◽  
J.M. Bowen ◽  
E.F. Walborg
Keyword(s):  
Surface Properties ◽  
Ricinus Communis ◽  
Rat Kidney ◽  
Leukemia Virus ◽  
Viral Envelope ◽  
Virus Particles ◽  
Chemically Induced ◽  
Sarcoma Virus ◽  
Hepatocarcinoma Cells ◽  
Type C

Several years ago Karasaki (1) reported the production of type C virus particles by Novikoff ascites hepatocarcinoma cells. More recently, Weinstein (2) has reported the presence of type C virus particles in cell cultures derived from transplantable and primary hepatocellular carcinomas. To date, the biological function of these virus and their significance in chemically induced hepatocarcinogenesis are unknown. The present studies were initiated to determine a possible role for type C virus particles in chemically induced hepatocarcinogenesis. This communication describes results of studies on the biological and surface properties of type C virus associated with Novikoff hepatocarcinoma cells.Ecotropic and xenotropic murine leukemia virus (MuLV) activity in ascitic fluid of Novikoff tumor-bearing rats was assayed in murine sarcoma virus transformed S+L- mouse cells and S+L- mink cells, respectively. The presence of sarcoma virus activity was assayed in non-virus-producing normal rat kidney (NRK) cells. Ferritin conjugates of concanavalin A (Fer-Con wheat germ agglutinin (Fer-WGA), and Ricinus communis agglutinins I and II (Fer-RCAI and Fer-RCAII) were used to probe the structure and topography of saccharide determinants present on the viral envelope.

Caspase-8 acts as a tumor suppressor in chemically induced hepatocarcinogenesis in mice

2014 ◽  
Vol 52 (01) ◽  
Author(s):  
HM Zimmermann ◽  
N Moro ◽  
R Sonntag ◽  
JM Bangen ◽  
YA Nevzorova ◽  
...  
Keyword(s):  
Tumor Suppressor ◽  
Caspase 8 ◽  
Chemically Induced

Hepatic B cell leukemia-3 attenuates chemically-induced hepatocarcinogenesis in mice

2015 ◽  
Vol 53 (12) ◽  
Author(s):  
N Gehrke ◽  
MA Wörns ◽  
Y Alt ◽  
A Waisman ◽  
N Hoevelmeyer ◽  
...  
Keyword(s):  
B Cell ◽  
Cell Leukemia ◽  
Chemically Induced ◽  
B Cell Leukemia

Effect of omega-3 on chemically induced hepatitis in rats

Planta Medica ◽  
2016 ◽  
Vol 81 (S 01) ◽  
pp. S1-S381
Author(s):  
J Hussein ◽  
DA Elmatty ◽  
D Medhat ◽  
NM Mesbah ◽  
AR Farrag ◽  
...  
Keyword(s):  
Omega 3 ◽  
Chemically Induced
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