scholarly journals Sleep‐wake Characteristics in a Mouse Model of Severe Traumatic Brain Injury: Relation to Post‐Traumatic Epilepsy.

2020 ◽  
Author(s):  
Sai Sruthi Konduru ◽  
Eli P Wallace ◽  
Jesse A Pfammatter ◽  
Paulo V Rodrigues ◽  
Mathew V Jones ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Mouse Model ◽  
Severe Traumatic Brain Injury ◽  
Post Traumatic ◽  
Post Traumatic Epilepsy ◽  
Traumatic Epilepsy ◽  
Wake Characteristics

The impact of prophylactic treatment on post-traumatic epilepsy after severe traumatic brain injury

Brain Injury ◽  
2007 ◽  
Vol 21 (5) ◽  
pp. 499-504 ◽  
Author(s):  
R. Formisano ◽  
C. Barba ◽  
M. G. Buzzi ◽  
J. Newcomb-Fernandez ◽  
F. Menniti-Ippolito ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Severe Traumatic Brain Injury ◽  
Prophylactic Treatment ◽  
Post Traumatic ◽  
Post Traumatic Epilepsy ◽  
The Impact ◽  
Traumatic Epilepsy

Time Interval Between Traumatic Brain Injury And Post Traumatic Epilepsy

2013 ◽  
Vol 21 (2) ◽  
pp. 222-228
Author(s):  
Daniel Garbin Di Luca ◽  
Glenda Corrêa Borges de Lacerda
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
First Year ◽  
Time Interval ◽  
Partial Seizures ◽  
Complex Partial Seizures ◽  
Post Traumatic ◽  
Faster Development ◽  
Post Traumatic Epilepsy ◽  
Traumatic Epilepsy

Introduction. The estimated time interval in which an individual can develop Post Traumatic Epilepsy (PTE) after a traumatic brain injury (TBI) is not clear. Objective. To assess the possible influence of the clinical features in the time interval between TBI and PTE develop­ment. Method. We analyzed retrospectively 400 medical records from a tertiary Brazilian hospital. We selected and reevaluated 50 patients and data was confronted with the time between TBI and PTE devel­opment by a Kaplan-Meier survival analysis. A Cox-hazard regression was also conducted to define the characteristics that could be involved in the latent period of the PTE development. Results. Patients devel­oped PTE especially in the first year (56%). We found a tendency of a faster development of PTE in patients older than 24 years (P<0.0001) and in men (P=0.03). Complex partial seizures evolving to generalized seizures were predominant in patients after moderate (37.7%) and severe (48.8%) TBIs, and simple partial seizures evolving to general­ized seizures in mild TBIs (45.5%). Conclusions. Our data suggest that the first year after a TBI is the most critical period for PTE de­velopment and those males older than 24 years could have a faster development of PTE.

scholarly journals Epileptiform activity in traumatic brain injury predicts post-traumatic epilepsy

2018 ◽  
Vol 83 (4) ◽  
pp. 858-862 ◽  
Author(s):  
Jennifer A. Kim ◽  
Emily J. Boyle ◽  
Alexander C. Wu ◽  
Andrew J. Cole ◽  
Kevin J. Staley ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Epileptiform Activity ◽  
Post Traumatic ◽  
Post Traumatic Epilepsy ◽  
Traumatic Epilepsy

scholarly journals Animal Models of Post-Traumatic Epilepsy

Diagnostics ◽  
2019 ◽  
Vol 10 (1) ◽  
pp. 4 ◽  
Author(s):  
Kristin A. Keith ◽  
Jason H. Huang
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Head Injury ◽  
Animal Models ◽  
Recurrent Seizure ◽  
Post Traumatic ◽  
Post Traumatic Epilepsy ◽  
The Brain ◽  
Underlying Pathophysiology ◽  
Traumatic Epilepsy

Traumatic brain injury is the leading cause of morbidity and mortality worldwide, with the incidence of post-traumatic epilepsy increasing with the severity of the head injury. Post-traumatic epilepsy (PTE) is defined as a recurrent seizure disorder secondary to trauma to the brain and has been described as one of the most devastating complications associated with TBI (Traumatic Brain Injury). The goal of this review is to characterize current animal models of PTE and provide succinct protocols for the development of each of the currently available animal models. The development of translational and effective animal models for post-traumatic epilepsy is critical in both elucidating the underlying pathophysiology associated with PTE and providing efficacious clinical breakthroughs in the management of PTE.

A rapid lateral fluid percussion injury rodent model of traumatic brain injury and post-traumatic epilepsy

Neuroreport ◽  
2014 ◽  
pp. 1 ◽  
Author(s):  
Mustafa Q. Hameed ◽  
Grant S. Goodrich ◽  
Sameer C. Dhamne ◽  
Asa Amandusson ◽  
Tsung-Hsun Hsieh ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Rodent Model ◽  
Fluid Percussion ◽  
Fluid Percussion Injury ◽  
Post Traumatic ◽  
Lateral Fluid Percussion ◽  
Post Traumatic Epilepsy ◽  
Traumatic Epilepsy
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