Cytocidal and filamentous response ofEscherichia coli cells exposed to low concentrations of hydrogen peroxide and hydroxyl radical scavengers

1991 ◽  
Vol 18 (1) ◽  
pp. 22-27 ◽  
Author(s):  
Giorgio Brandi ◽  
Leonardo Salvaggio ◽  
Flaminio Cattabeni ◽  
Orazio Cantoni ◽  
K. E. Mortelmans
Keyword(s):  
Hydrogen Peroxide ◽  
Hydroxyl Radical ◽  
Ofescherichia Coli ◽  
Radical Scavengers ◽  
Low Concentrations ◽  
Hydroxyl Radical Scavengers

Gentamicin-induced mobilization of iron from renal cortical mitochondria

1993 ◽  
Vol 265 (3) ◽  
pp. F435-F439 ◽  
Author(s):  
N. Ueda ◽  
B. Guidet ◽  
S. V. Shah
Keyword(s):  
Hydrogen Peroxide ◽  
Hydroxyl Radical ◽  
Tissue Injury ◽  
Iron Chelator ◽  
Iron Release ◽  
Radical Scavengers ◽  
Iron Mobilization ◽  
No Formation ◽  
Hydroxyl Radical Scavengers ◽  
Dose Dependent

Iron, presumably by participating in generation of hydroxyl radical or other oxidant species or initiation of lipid peroxidation, has been shown to play an important role in several models of tissue injury, including acute renal failure induced by the antibiotic gentamicin. However, the sources of iron remain unknown. Rat renal mitochondria incubated at 37 degrees C with gentamicin resulted in a time- (15-60 min) and a dose-dependent (0.01-5 mM) iron release as measured by formation of iron-bathophenanthroline sulfonate complex FeII-(BPS)3 [at 60 min, control: 1.2 +/- 0.1 nmol/mg protein, n = 7; gentamicin (5 mM): 5.1 +/- 0.4 nmol/mg protein, n = 7]. No formation of FeII(BPS)3 complex was detected in the absence of mitochondria or when incubations were carried out at 0 degrees C. Similar results were obtained when 2,2'-dipyridyl, another iron chelator, was used for measurement of iron release. On the basis on our previous study that gentamicin enhances generation of hydrogen peroxide by renal cortical mitochondria, we examined whether effect of gentamicin on iron release is mediated by hydrogen peroxide. Catalase (which decomposes hydrogen peroxide), but not heat-inactivated catalase, as well as pyruvate, a potent scavenger of hydrogen peroxide, prevented gentamicin-induced iron mobilization. Superoxide dismutase, a scavenger of superoxide anion, or hydroxyl radical scavengers (dimethylthiourea or sodium benzoate) had no effect. Taken together, the data with scavengers indicate that gentamicin-induced iron mobilization from mitochondria is mediated by hydrogen peroxide.

scholarly journals Ferrous ion-EDTA-stimulated phospholipid peroxidation. A reaction changing from alkoxyl-radical- to hydroxyl-radical-dependent initiation

1984 ◽  
Vol 224 (3) ◽  
pp. 697-701 ◽  
Author(s):  
J M C Gutteridge
Keyword(s):  
Hydrogen Peroxide ◽  
Lipid Peroxidation ◽  
Hydroxyl Radical ◽  
Hydroxyl Radicals ◽  
Superoxide Radicals ◽  
Ferrous Ion ◽  
Radical Scavengers ◽  
Alkoxyl Radical ◽  
Phospholipid Peroxidation ◽  
Hydroxyl Radical Scavengers

The stimulatory effect of ferrous salts on the peroxidation of phospholipids can be enhanced by EDTA when the concentration of Fe2+ in the reaction is greater than that of EDTA. Hydroxyl-radical scavengers do not inhibit peroxidation until the concentrations of Fe2+ and EDTA in the reaction are equal. Lipid peroxidation is then substantially initiated by hydroxyl radicals derived from a Fenton-type reaction requiring hydrogen peroxide. Superoxide radicals appear to play some role in the formation of initiating species.

Inhibition of human neutrophil binding to hydrogen peroxide-treated endothelial cells by camp and hydroxyl radical scavengers

1996 ◽  
Vol 21 (1) ◽  
pp. 15-23 ◽  
Author(s):  
Elisabeth Franzini ◽  
Hassan Sellak ◽  
Claude Marquetty ◽  
Catherine Babin-Chevaye ◽  
Jacques Hakim ◽  
...  
Keyword(s):  
Hydrogen Peroxide ◽  
Endothelial Cells ◽  
Hydroxyl Radical ◽  
Human Neutrophil ◽  
Radical Scavengers ◽  
Hydroxyl Radical Scavengers

Post-hypoxic cellular disintegration in glycine-preserved renal tubules is attenuated by hydroxyl radical scavengers and iron chelators

2008 ◽  
Vol 393 (3) ◽  
pp. 303-310 ◽  
Author(s):  
Mohammed R. Moussavian ◽  
Jan E. Slotta ◽  
Otto Kollmar ◽  
Michael D. Menger ◽  
Gernot Gronow ◽  
...  
Keyword(s):  
Hydroxyl Radical ◽  
Iron Chelators ◽  
Renal Tubules ◽  
Radical Scavengers ◽  
Hydroxyl Radical Scavengers

Role of hydroxyl radical scavengers dimethyl sulfoxide, alcohols and methional in the inhibition of prostaglandin biosynthesis

1976 ◽  
Vol 11 (4) ◽  
pp. 599-607 ◽  
Author(s):  
Rao V. Panganamala ◽  
Hari M. Sharma ◽  
Richard E. Heikkila ◽  
Jack C. Geer ◽  
David G. Cornwell
Keyword(s):  
Hydroxyl Radical ◽  
Dimethyl Sulfoxide ◽  
Radical Scavengers ◽  
Prostaglandin Biosynthesis ◽  
Hydroxyl Radical Scavengers
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