Increased frequency of chromosomal damage in peripheral blood lymphocytes up to nine years following curative chemotherapy of patients with testicular carcinoma

1991 ◽  
Vol 17 (2) ◽  
pp. 71-78 ◽  
Author(s):  
Susanne Osanto ◽  
Joyphi C. P. Thijssen ◽  
Viola M. Woldering ◽  
Jaap L. S. Van Rijn ◽  
Adayapalam T. Natarajan ◽  
...  
Keyword(s):  
Peripheral Blood ◽  
Peripheral Blood Lymphocytes ◽  
Chromosomal Damage ◽  
Blood Lymphocytes ◽  
Testicular Carcinoma

Chromosomal damage in peripheral blood lymphocytes of patients treated for testicular cancer

1990 ◽  
Vol 84 (2) ◽  
pp. 191-194 ◽  
Author(s):  
Eva van den Berg-de Ruiter ◽  
Bauke de Jong ◽  
Nanno H. Mulder ◽  
Gerard J. te Meerman ◽  
Heimen Schraffordt Koops ◽  
...  
Keyword(s):  
Testicular Cancer ◽  
Peripheral Blood ◽  
Peripheral Blood Lymphocytes ◽  
Chromosomal Damage ◽  
Blood Lymphocytes

Chromosomal damage in peripheral blood lymphocytes of newly diagnosed cancer patients and healthy controls

2010 ◽  
Vol 31 (7) ◽  
pp. 1238-1241 ◽  
Author(s):  
P. Vodicka ◽  
Z. Polivkova ◽  
S. Sytarova ◽  
H. Demova ◽  
M. Kucerova ◽  
...  
Keyword(s):  
Cancer Patients ◽  
Peripheral Blood ◽  
Peripheral Blood Lymphocytes ◽  
Healthy Controls ◽  
Newly Diagnosed ◽  
Chromosomal Damage ◽  
Blood Lymphocytes

scholarly journals Chromosomal damage and telomere length in peripheral blood lymphocytes of cancer patients

2020 ◽  
Author(s):  
Sona Vodenkova ◽  
Michal Kroupa ◽  
Zdenka Polivkova ◽  
Ludovit Musak ◽  
Miloslav Ambrus ◽  
...  
Keyword(s):  
Telomere Length ◽  
Cancer Patients ◽  
Peripheral Blood ◽  
Peripheral Blood Lymphocytes ◽  
Chromosomal Damage ◽  
Blood Lymphocytes

scholarly journals Chromosomal damage in peripheral blood lymphocytes from nurses occupationally exposed to chemicals

2013 ◽  
Vol 33 (9) ◽  
pp. 897-903 ◽  
Author(s):  
A Santovito ◽  
P Cervella ◽  
M Delpero
Keyword(s):  
Peripheral Blood ◽  
Peripheral Blood Lymphocytes ◽  
Control Group ◽  
Low Doses ◽  
Chromosomal Damage ◽  
Blood Lymphocytes ◽  
Genome Damage ◽  
Occupationally Exposed ◽  
Index Value ◽  
And Control

In the present study, we evaluated the induced genome damage in peripheral blood lymphocytes from a sample of nurses occupationally exposed to low doses of different chemicals. A comprehensive multi-biomarker approach using cytogenetic endpoints was employed for analyzing chromosomal aberrations (CAs) and sister chromatid exchange (SCE) assay. The study included 20 nurses and 20 control subjects matched in age, gender and smoking habits. Nurses were exposed to different chemicals, such as cytostatic drugs, anaesthetics, formaldehyde and other sterilizing gases. Significant differences were found between exposure group and control group in terms of SCEs frequency ( p < 0.001) but not in terms of replication index value ( p = 0.845) and CAs ( p = 0.236). Regression analyses indicated that the age and the exposure years did not influence the amount of the chromosomal damage among nurses. Vice versa, among controls, a positive correlation was found between the number of SCEs and age. In conclusion, our results suggest that a continuous long-term exposure to low doses of chemicals could result in increased levels of SCEs among nurses. This data emphasize the importance of biomonitoring nurses and other hospital workers handling drugs.

scholarly journals Bleomycin-induced chromosomal damage and shortening of telomeres in peripheral blood lymphocytes of incident cancer patients

2017 ◽  
Vol 57 (2) ◽  
pp. 61-69 ◽  
Author(s):  
Michal Kroupa ◽  
Zdenka Polivkova ◽  
Sivaramakrishna Rachakonda ◽  
Michaela Schneiderova ◽  
Sona Vodenkova ◽  
...  
Keyword(s):  
Cancer Patients ◽  
Peripheral Blood ◽  
Peripheral Blood Lymphocytes ◽  
Chromosomal Damage ◽  
Blood Lymphocytes ◽  
Incident Cancer
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