Metabolism and bacterial mutagenicity of binary mixtures of benzo(a)pyrene and polychlorinated aromatic hydrocarbons

1990 ◽  
Vol 16 (4) ◽  
pp. 238-245 ◽  
Author(s):  
K. C. Donnelly ◽  
K. W. Brown ◽  
C. S. Anderson ◽  
G. C. Barbee ◽  
S. H. Safe ◽  
...  
2020 ◽  
Vol 11 (3) ◽  
pp. 10052-10058

In the present study, the excess molar volume (VE) and the deviations in intermolecular free length (ΔLf), isentropic compressibility (Δβs), acoustic impedance (ΔZ), and ultrasonic velocity (ΔU) were calculated using the experimentally measured values of density (ρ) and ultrasonic velocity (U) of binary mixtures of an acidic organophosphoric extractant (DEHPA) with two substituted aromatic hydrocarbons, i.e., p-xylene and toluene at 303.15K and atmospheric pressure, 0.1MPa over the entire composition range of DEHPA. The results of both binary mixtures have been presented graphically and compared in terms of molecular interaction between unlike molecules of the mixtures, which outcome may be applied in the solvent extraction process.


1979 ◽  
Vol 236 (6) ◽  
pp. E763
Author(s):  
J Manis ◽  
G Kim

Oral and intraperitoneal treatment of rats with a single dose of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), 33 microgram/kg, causes a 41--67% increase in iron adsorption in vivo. The major effect is on the transfer of iron from the mucosa into the bloodstream rather than on the uptake of iron from the lumen of the gut. These results are confirmed in studies with everted gut sacs. The effect is maximal at 1--2 days with a dose of 22-42 microgram/kg. Calcium transport is inhibited by TCDD treatment, whereas galactose and proline transport are unaffected. Treatment of rats with 1,1,1-trichloro-2,2-bis(p-chlorophenyl)ethane also stimulates iron transport. Concomitant with iron transport stimulation, aryl hydrocarbon hydroxylase activity in the intestine and liver is increased by TCDD treatment. These studies suggest that polychlorinated aromatic hydrocarbons, which are environmental health hazards, may effect the intestinal absorption of essential mineral nutrients.


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