In vivo Characterization of the Radiosensitizing Effect of a Very Low Dose of BrdU in Murine Cells Exposed to Low‐Dose Radiation

2019 ◽  
Author(s):  
Virginia Cruz‐Vallejo ◽  
Rocío Ortíz‐Muñiz ◽  
Teresita Vallarino‐Kelly ◽  
Elsa Cervantes‐Ríos ◽  
Pedro Morales‐Ramírez
Keyword(s):  
Low Dose ◽  
Low Dose Radiation ◽  
Radiosensitizing Effect ◽  
In Vivo Characterization ◽  
Dose Radiation

scholarly journals Low-dose radiation therapy: a treatment for pneumonia resulting from COVID-19

2021 ◽  
pp. 1-4
Author(s):  
Hamid Ghaznavi ◽  
Farideh Elahimanesh ◽  
Jamil Abdolmohammadi ◽  
Meysam Mirzaie ◽  
Sadegh Ghaderi
Keyword(s):  
Lung Cancer ◽  
Radiation Therapy ◽  
Low Dose ◽  
Distress Syndrome ◽  
Lung Cancer Risk ◽  
Low Dose Radiation ◽  
The World ◽  
Dose Radiation

Abstract Background: The Coronavirus disease 2019 (COVID-19) is spreading rapidly throughout the world. Lung is the primary organ which the COVID-19 virus affects and leads to pneumonia, an acute respiratory distress syndrome. COVID-19 infects the lower respiratory system, and the lung’s response to this infection is recruiting macrophages and monocytes leading to inflammation, this response causes widespread damage to the lung’s airways. Aim: The purpose of this study is to review studies of using low-dose radiation as a treatment for the inflammation of the tissue and pneumonia resulting from COVID-19. These studies were compared with the risk of developing lung cancer during performed dose for the treatment of COVID-19 in radiation therapy. Materials and methods: Our study focused on in vitro, in vivo and clinical reports of using low-dose radiation for the treatment of inflammation, pneumonia and COVID-19. The risk of lung cancer resulting from suggested dose in these studies was also evaluated. Conclusion: From the review of articles, we have found that low-dose radiation can lead to improvement in inflammation in different line cells and animals; in addition, it has been effective in treating inflammation and pneumonia caused by COVID-19 in human up to 80%. Since suggested doses do not remarkably increase the lung cancer risk, low-dose radiation can be an adjuvant treatment for COVID-19 patients.

106 poster: Characterization of Flt-Pet Response to High- and Low-Dose Radiation of a Lung Cancer Xenograft in Mice

2010 ◽  
Vol 94 ◽  
pp. S41-S42
Author(s):  
H. Keller ◽  
D. Vines ◽  
M. Lakshman ◽  
M. Dunne ◽  
P. Lindsay ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Low Dose ◽  
Low Dose Radiation ◽  
Flt Pet ◽  
Dose Radiation

scholarly journals Injectable Hydrogel for Synergetic Low Dose Radiotherapy, Chemodynamic Therapy and Photothermal Therapy

2021 ◽  
Vol 9 ◽  
Author(s):  
Mingzhu Chen ◽  
Ziqi Wang ◽  
Weilong Suo ◽  
Zhirong Bao ◽  
Hong Quan
Keyword(s):  
Photothermal Therapy ◽  
Low Dose ◽  
Tumor Therapy ◽  
Intratumoral Injection ◽  
Low Dose Radiation ◽  
Injectable Hydrogel ◽  
Low Dose Radiotherapy ◽  
Dose Radiation

Higher doses of radiotherapy (RT) are associated with resistance induction, therefore highly selective and controllable radiosensitizers are urgently needed. To address this issue, we developed a FeGA-based injectable hydrogel system (FH) that can be used in combination with low-dose radiation. Our FH can deliver FeGA directly to the tumor site via intratumoral injection, where it is a reservoir-based system to conserve FeGA. The photothermal properties of FeGA steadily dissolve FH under laser irradiation, and, simultaneously, FeGA reacts with a large amount of H2O2 in the cell to produce OH (Fenton reaction) which is highly toxic to mitochondria, rendering the cell inactive and reducing radiotherapy resistance. In vivo and in vitro studies suggest that combining the FH and NIR irradiation with RT (2Gy) can significantly reduce tumor proliferation without side effects such as inflammation. To conclude, this is the first study to achieve combined chemodynamic therapy (CDT) and photothermal therapy (PTT) in situ treatment, and the best therapeutic effect can be obtained with a low-dose radiation combination, thus expanding the prospects of FeGA-based tumor therapy.

scholarly journals Biophysical Characterization of the Leukemic Bone Marrow Vasculature Reveals Benefits of Neoadjuvant Low-Dose Radiation Therapy

2021 ◽  
Vol 109 (1) ◽  
pp. 60-72
Author(s):  
Jamison Brooks ◽  
Bijender Kumar ◽  
Darren M. Zuro ◽  
Jonathan D. Raybuck ◽  
Srideshikan Sargur Madabushi ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Radiation Therapy ◽  
Low Dose ◽  
Low Dose Radiation ◽  
Biophysical Characterization ◽  
Dose Radiation

scholarly journals In Vivo Mutagenic Effect of Very Low Dose Radiation

Dose-Response ◽  
2006 ◽  
Vol 4 (4) ◽  
pp. dose-response.0 ◽  
Author(s):  
Pamela J. Sykes ◽  
Tanya K. Day ◽  
Sarah J. Swinburne ◽  
Joanne M. Lane ◽  
Alexander A. Morley ◽  
...  
Keyword(s):  
Low Dose ◽  
Mutagenic Effect ◽  
Low Dose Radiation ◽  
Dose Radiation

scholarly journals Low-Dose Radiation Induces Adaptive Response in Normal Cells, but not in Tumor Cells: In vitro and in vivo Studies

2008 ◽  
Vol 49 (3) ◽  
pp. 219-230 ◽  
Author(s):  
Hongyu JIANG ◽  
Wei LI ◽  
Xiuyi LI ◽  
Lu CAI ◽  
Guanjun WANG
Keyword(s):  
Tumor Cells ◽  
Adaptive Response ◽  
Low Dose ◽  
In Vivo Studies ◽  
Low Dose Radiation ◽  
Normal Cells ◽  
Dose Radiation
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