scholarly journals Genetic variation associated with chromosomal aberration frequency: A genome-wide association study

2018 ◽  
Vol 60 (1) ◽  
pp. 17-28 ◽  
Author(s):  
Yasmeen Niazi ◽  
Hauke Thomsen ◽  
Bozena Smolkova ◽  
Ludmila Vodickova ◽  
Sona Vodenkova ◽  
...  
Keyword(s):  
Genetic Variation ◽  
Association Study ◽  
Chromosomal Aberration ◽  
Genome Wide Association Study ◽  
Genome Wide Association ◽  
Aberration Frequency ◽  
Genome Wide ◽  
A Genome

scholarly journals A genome-wide association study demonstrates significant genetic variation for fracture risk in Thoroughbred racehorses

BMC Genomics ◽  
2014 ◽  
Vol 15 (1) ◽  
pp. 147 ◽  
Author(s):  
Sarah C Blott ◽  
June E Swinburne ◽  
Charlene Sibbons ◽  
Laura Y Fox-Clipsham ◽  
Maud Helwegen ◽  
...  
Keyword(s):  
Genetic Variation ◽  
Fracture Risk ◽  
Association Study ◽  
Genome Wide Association Study ◽  
Genome Wide Association ◽  
Thoroughbred Racehorses ◽  
Genome Wide ◽  
A Genome

scholarly journals A genome-wide association study identifies novel susceptibility genetic variation for thyrotoxic hypokalemic periodic paralysis

2012 ◽  
Vol 57 (5) ◽  
pp. 301-304 ◽  
Author(s):  
Wallaya Jongjaroenprasert ◽  
Theerawut Phusantisampan ◽  
Surakameth Mahasirimongkol ◽  
Taisei Mushiroda ◽  
Nattiya Hirankarn ◽  
...  
Keyword(s):  
Genetic Variation ◽  
Association Study ◽  
Genome Wide Association Study ◽  
Periodic Paralysis ◽  
Genome Wide Association ◽  
Hypokalemic Periodic Paralysis ◽  
Genome Wide ◽  
A Genome ◽  
Thyrotoxic Hypokalemic Periodic Paralysis

A genome-wide association study to detect genetic variation for postpartum dysgalactia syndrome in five commercial pig breeding lines

2013 ◽  
Vol 44 (5) ◽  
pp. 502-508 ◽  
Author(s):  
Regine Preissler ◽  
Jens Tetens ◽  
Kerstin Reiners ◽  
Holger Looft ◽  
Nicole Kemper
Keyword(s):  
Genetic Variation ◽  
Association Study ◽  
Genome Wide Association Study ◽  
Genome Wide Association ◽  
Breeding Lines ◽  
Genome Wide ◽  
A Genome

scholarly journals Genetic variation in cervical preinvasive and invasive disease: a genome-wide association study

2021 ◽  
Vol 22 (4) ◽  
pp. 548-557 ◽  
Author(s):  
Sarah J Bowden ◽  
Barbara Bodinier ◽  
Ilkka Kalliala ◽  
Verena Zuber ◽  
Dragana Vuckovic ◽  
...  
Keyword(s):  
Genetic Variation ◽  
Association Study ◽  
Genome Wide Association Study ◽  
Invasive Disease ◽  
Genome Wide Association ◽  
Genome Wide ◽  
A Genome

Associations between age of menarche and genetic variation in women of African descent: genome-wide association study and polygenic score analysis

2021 ◽  
pp. jech-2020-216000
Author(s):  
Molly Scannell Bryan ◽  
Temidayo Ogundiran ◽  
Oladosu Ojengbede ◽  
Wei Zheng ◽  
William Blot ◽  
...  
Keyword(s):  
Genetic Variation ◽  
Association Study ◽  
Genome Wide Association Study ◽  
African Ancestry ◽  
Genome Wide Association ◽  
Age At Menarche ◽  
Polygenic Score ◽  
Genome Wide ◽  
A Genome ◽  
The Usa

IntroductionMany diseases of adulthood are associated with a woman’s age at menarche. Genetic variation affects age at menarche, but it remains unclear whether in women of African ancestry the timing of menarche is regulated by genetic variants that were identified in predominantly European and East Asian populations.MethodsWe explored the genetic architecture of age at menarche in 3145 women of African ancestry who live in the USA, Barbados and Nigeria. We undertook a genome-wide association study, and evaluated the performance of previously identified variants.ResultsOne variant was associated with age at menarche, a deletion at chromosome 2 (chr2:207216165) (p=1.14×10−8). 349 genotyped variants overlapped with these identified in populations of non-African ancestry; these replicated weakly, with 51.9% having concordant directions of effect. However, collectively, a polygenic score constructed of those previous variants was suggestively associated with age at menarche (beta=0.288 years; p=0.041). Further, this association was strong in women enrolled in the USA and Barbados (beta=0.445 years, p=0.008), but not in Nigerian women (beta=0.052 years; p=0.83).DiscussionThis study suggests that in women of African ancestry the genetic drivers of age at menarche may differ from those identified in populations of non-African ancestry, and that these differences are more pronounced in women living in Nigeria, although some associated trait loci may be shared across populations. This highlights the need for well-powered ancestry-specific genetic studies to fully characterise the genetic influences of age at menarche.

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