Genotoxicity of synthetic amorphous silica nanoparticles in rats following short-term exposure, part 2: Intratracheal instillation and intravenous injection

2014 ◽  
Vol 56 (2) ◽  
pp. 228-244 ◽  
Author(s):  
Yves Guichard ◽  
Marie-Aline Maire ◽  
Sylvie Sébillaud ◽  
Caroline Fontana ◽  
Cristina Langlais ◽  
...  
Keyword(s):  
Silica Nanoparticles ◽  
Intravenous Injection ◽  
Amorphous Silica ◽  
Intratracheal Instillation ◽  
Short Term ◽  
Short Term Exposure ◽  
Synthetic Amorphous Silica

Genotoxicity of synthetic amorphous silica nanoparticles in rats following short-term exposure. Part 1: Oral route

2014 ◽  
Vol 56 (2) ◽  
pp. 218-227 ◽  
Author(s):  
Adeline Tarantini ◽  
Sylvie Huet ◽  
Gérard Jarry ◽  
Rachelle Lanceleur ◽  
Martine Poul ◽  
...  
Keyword(s):  
Silica Nanoparticles ◽  
Amorphous Silica ◽  
Oral Route ◽  
Short Term ◽  
Short Term Exposure ◽  
Synthetic Amorphous Silica

scholarly journals Insights on toxicity, safe handling and disposal of silica aerogels and amorphous nanoparticles

2021 ◽  
Author(s):  
João P. Vareda ◽  
Carlos A. García-González ◽  
Artur J. M. Valente ◽  
Rosana Simón-Vázquez ◽  
Marina Stipetic ◽  
...  
Keyword(s):  
Silica Nanoparticles ◽  
Amorphous Silica ◽  
Silica Aerogels ◽  
Safe Handling ◽  
Synthetic Amorphous Silica ◽  
Amorphous Nanoparticles

The toxicity and ecotoxicity effects, handling and disposal of synthetic amorphous silica nanoparticles and aerogels are reviewed and discussed.

Amorphous silica nanoparticles induced spleen and liver toxicity after acute intravenous exposure in male and female rats

2021 ◽  
pp. 074823372110105
Author(s):  
Roberta Tassinari ◽  
Andrea Martinelli ◽  
Mauro Valeri ◽  
Francesca Maranghi
Keyword(s):  
Amorphous Silica ◽  
Liver Toxicity ◽  
Female Rats ◽  
Histopathological Analysis ◽  
Short Term ◽  
Short Term Treatment ◽  
Male And Female ◽  
Male And Female Rats ◽  
Target Organs ◽  
Short Term Exposure

Synthetic amorphous silica (SAS) nanomaterial – consisting of aggregates and agglomerates of primary silicon dioxide (SiO2) particles in the nanorange (<100 nm) – is commonly used as excipient in pharmaceuticals, in cosmetics and as food additive (E551). The available data suggest that SAS nanoparticles (NP) after intravenous (IV) exposure persist in liver and spleen; however, insufficient data exist to verify whether SAS may also induce adverse effects. The aim of the present study was to verify the potential long-term effects of SAS NP (NM-203) on spleen and liver as target organs following short-term exposure. Adult male and female Sprague-Dawley rats were treated by IV injection in the tail vein with a single (1-day) dose (SD) and repeated (5-day) doses (RD) of 20 mg/kg bw per day of SAS dispersed in sterile saline solution as vehicle. Histopathological examinations of target organs were performed after 90 days. Tissue biodistribution and full characterization of NM-203, primary particle size 13–45 nm, was performed within the framework of the Nanogenotox project. No mortality or general toxicity occurred; histopathological analysis showed splenomegaly in the RD group accompanied by inflammatory granulomas in both sexes. Granulomas were also present in liver parenchyma in the RD (both sexes) and SD groups (male only). The histopathological results indicated that SAS NP have the potential to persist and induce sex-specific chronic inflammatory lesions in spleen and liver upon short-term treatment. Overall, the data showed that the widespread use of silica in drugs might elicit chronic reactions in spleen and liver prompting to the need of further investigations on the safety of SAS NP.

Synthetic amorphous silica nanoparticles: toxicity, biomedical and environmental implications

2020 ◽  
Vol 5 (12) ◽  
pp. 886-909 ◽  
Author(s):  
Jonas G. Croissant ◽  
Kimberly S. Butler ◽  
Jeffrey I. Zink ◽  
C. Jeffrey Brinker
Keyword(s):  
Silica Nanoparticles ◽  
Amorphous Silica ◽  
Environmental Implications ◽  
Synthetic Amorphous Silica ◽  
Nanoparticles Toxicity

Cardiovascular Toxicity of Different Sizes Amorphous Silica Nanoparticles in Rats After Intratracheal Instillation

2013 ◽  
Vol 13 (3) ◽  
pp. 194-207 ◽  
Author(s):  
Zhongjun Du ◽  
Dali Zhao ◽  
Li Jing ◽  
Guanqun Cui ◽  
Minghua Jin ◽  
...  
Keyword(s):  
Silica Nanoparticles ◽  
Amorphous Silica ◽  
Intratracheal Instillation ◽  
Cardiovascular Toxicity

scholarly journals In vitro cell transformation induced by synthetic amorphous silica nanoparticles

2017 ◽  
Vol 823 ◽  
pp. 22-27 ◽  
Author(s):  
Caroline Fontana ◽  
Anaïs Kirsch ◽  
Carole Seidel ◽  
Léa Marpeaux ◽  
Christian Darne ◽  
...  
Keyword(s):  
Silica Nanoparticles ◽  
Amorphous Silica ◽  
Cell Transformation ◽  
Synthetic Amorphous Silica
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