Cell type-dependent gene transcription profile in a three-dimensional human skin tissue model exposed to low doses of ionizing radiation: Implications for medical exposures

2012 ◽  
Vol 53 (4) ◽  
pp. 247-259 ◽  
Author(s):  
Claere von Neubeck ◽  
Harish Shankaran ◽  
Norman J. Karin ◽  
Paula M. Kauer ◽  
William B. Chrisler ◽  
...  
Keyword(s):  
Ionizing Radiation ◽  
Human Skin ◽  
Gene Transcription ◽  
Three Dimensional ◽  
Low Doses ◽  
Transcription Profile ◽  
Cell Type ◽  
Tissue Model ◽  
Gene Transcription Profile ◽  
Human Skin Tissue

scholarly journals The photoprotective effects of almond phytonutrients in a three‐dimensional human skin tissue model

2012 ◽  
Vol 26 (S1) ◽  
Author(s):  
Julie A Evans ◽  
Jonathan Garlick ◽  
Elizabeth J Johnson ◽  
Xiang-Dong Wang ◽  
C-Y. Oliver Chen
Keyword(s):  
Human Skin ◽  
Three Dimensional ◽  
Skin Tissue ◽  
Tissue Model ◽  
Human Skin Tissue

scholarly journals Three-dimensional experiments and individual based simulations show that cell proliferation drives melanoma nest formation in human skin tissue

2018 ◽  
Vol 12 (1) ◽  
Author(s):  
Parvathi Haridas ◽  
Alexander P. Browning ◽  
Jacqui A. McGovern ◽  
D. L. Sean McElwain ◽  
Matthew J. Simpson
Keyword(s):  
Cell Proliferation ◽  
Human Skin ◽  
Three Dimensional ◽  
Skin Tissue ◽  
Human Skin Tissue

scholarly journals Phenotypic transitions enacted by simulated microgravity do not alter coherence in gene transcription profile

2019 ◽  
Vol 5 (1) ◽  
Author(s):  
Agnese Po ◽  
Alessandro Giuliani ◽  
Maria Grazia Masiello ◽  
Alessandra Cucina ◽  
Angela Catizone ◽  
...  
Keyword(s):  
Gene Expression ◽  
Gene Transcription ◽  
Simulated Microgravity ◽  
Correlation Coefficients ◽  
Transcription Profile ◽  
Random Positioning Machine ◽  
Functional Changes ◽  
Internal Gene ◽  
Gene Transcription Profile ◽  
Space Cell

AbstractCells in simulated microgravity undergo a reversible morphology switch, causing the appearance of two distinct phenotypes. Despite the dramatic splitting into an adherent-fusiform and a floating-spherical population, when looking at the gene-expression phase space, cell transition ends up in a largely invariant gene transcription profile characterized by only mild modifications in the respective Pearson’s correlation coefficients. Functional changes among the different phenotypes emerging in simulated microgravity using random positioning machine are adaptive modifications—as cells promptly recover their native phenotype when placed again into normal gravity—and do not alter the internal gene coherence. However, biophysical constraints are required to drive phenotypic commitment in an appropriate way, compatible with physiological requirements, given that absence of gravity foster cells to oscillate between different attractor states, thus preventing them to acquire a exclusive phenotype. This is a proof-of-concept of the adaptive properties of gene-expression networks supporting very different phenotypes by coordinated ‘profile preserving’ modifications.

scholarly journals Phosphoproteomics Profiling of Human Skin Fibroblast Cells Reveals Pathways and Proteins Affected by Low Doses of Ionizing Radiation

PLoS ONE ◽  
2010 ◽  
Vol 5 (11) ◽  
pp. e14152 ◽  
Author(s):  
Feng Yang ◽  
Katrina M. Waters ◽  
John H. Miller ◽  
Marina A. Gritsenko ◽  
Rui Zhao ◽  
...  
Keyword(s):  
Ionizing Radiation ◽  
Human Skin ◽  
Skin Fibroblast ◽  
Human Skin Fibroblast ◽  
Fibroblast Cells ◽  
Low Doses

scholarly journals 716 Effects of ammonia vapor exposure on viability in a human skin tissue model

2018 ◽  
Vol 138 (5) ◽  
pp. S122
Author(s):  
M. Bachelor ◽  
P. Hayden ◽  
J. Molignano ◽  
H. Garcia ◽  
K. Toon ◽  
...  
Keyword(s):  
Human Skin ◽  
Skin Tissue ◽  
Ammonia Vapor ◽  
Tissue Model ◽  
Human Skin Tissue
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