International round-robin study on the Ames fluctuation test

2012 ◽  
Vol 53 (3) ◽  
pp. 185-197 ◽  
Author(s):  
G. Reifferscheid ◽  
H.M. Maes ◽  
B. Allner ◽  
J. Badurova ◽  
S. Belkin ◽  
...  
2010 ◽  
Vol 47 (3) ◽  
pp. 533-541 ◽  
Author(s):  
Teppei Okumura ◽  
Mengu Cho ◽  
Virginie Inguimbert ◽  
Denis Payan ◽  
Boris Vayner ◽  
...  

1996 ◽  
Vol 42 (10) ◽  
pp. 1689-1694 ◽  
Author(s):  
E W Gunter ◽  
B A Bowman ◽  
S P Caudill ◽  
D B Twite ◽  
M J Adams ◽  
...  

Abstract Because of the increasing significance of folate nutriture to public health, a "round robin" interlaboratory comparison study was conducted to assess differences among methods. Twenty research laboratories participated in a 3-day analysis of six serum and six whole-blood pools. Overall means, SDs, and CVs derived from these results were compared within and across method types. Results reported for serum and whole-blood folate demonstrated overall CVs of 27.6% and 35.7%, respectively, across pools and two- to ninefold differences in concentrations between methods, with the greatest variation occurring at critical low folate concentrations. Although results for serum pools were less variable than those for whole-blood pools, substantial intermethod variation still occurred. The overall results underscore the urgent need for developing and validating reference methods for serum and whole-blood folate and for properly characterized reference materials. For evaluating study or clinical data, method-specific reference ranges (established with clinical confirmation of values for truly folate-deficient individuals) must be used.


Author(s):  
Yamamoto Masato ◽  
Onizawa Kunio ◽  
Yoshimoto Kentaro ◽  
Ogawa Takuya ◽  
Mabuchi Yasuhiro ◽  
...  

1990 ◽  
Author(s):  
Michael G. Hutchins ◽  
P. R. Dolley ◽  
Karlhanns Gindele ◽  
Michael Koehl ◽  
Ulrich Frei ◽  
...  

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