XRCC1 down-regulation in human cells leads to DNA-damaging agent hypersensitivity, elevated sister chromatid exchange, and reduced survival ofBRCA2mutant cells

2007 ◽  
Vol 48 (6) ◽  
pp. 491-500 ◽  
Author(s):  
Jinshui Fan ◽  
Paul F. Wilson ◽  
Heng-Kuan Wong ◽  
Salustra S. Urbin ◽  
Larry H. Thompson ◽  
...  
Keyword(s):  
Sister Chromatid ◽  
Sister Chromatid Exchange ◽  
Human Cells ◽  
Down Regulation

DNA repair replication, DNA breaks and sister-chromatid exchange in human cells treated with adriamycin in vitro

1983 ◽  
Vol 111 (2) ◽  
pp. 171-184 ◽  
Author(s):  
Bo Lambert ◽  
Margareta Sten ◽  
Stefan Söderhäll ◽  
Ulrik Ringborg ◽  
Rolf Lewensohn
Keyword(s):  
Dna Repair ◽  
Sister Chromatid ◽  
Sister Chromatid Exchange ◽  
Human Cells ◽  
Dna Breaks

An Evaluation of the Genotoxicity of O-Tyrosine, a Proposed Marker for Irradiated Food

1992 ◽  
Vol 55 (12) ◽  
pp. 1006-1008 ◽  
Author(s):  
JOSEPH G. SZEKELY ◽  
NOEMI CHUAQUI-OFFERMANNS ◽  
MARLENE GOODWIN ◽  
SABINE DELANEY
Keyword(s):  
Growth Rate ◽  
Sister Chromatid ◽  
Sister Chromatid Exchange ◽  
Chinese Hamster ◽  
Human Cells ◽  
Chinese Hamster Cells ◽  
Irradiated Food ◽  
In Cells

V79 Chinese hamster cells and Molt-4 human cells have been used to test the cellular and genetic toxicities of o-tyrosine addition at concentrations far in excess of that found after irradiation of chicken to 10 kGy (~1.3 μg/ml). No toxicity, as measured by sister chromatid exchange, micronuclei formation, or reproductive death, was seen in cells exposed to concentrations up to 100 μg/ml o-tyrosine. After 2 d in 200 μg/ml o-tyrosine, Molt-4 cells had a higher percentage of dead cells in the population, but the growth rate and micronuclei formation were not affected.

Sister chromatid exchange analysis of human cells exposed to diagnostic levels of ultrasound.

1991 ◽  
Vol 10 (12) ◽  
pp. 665-670 ◽  
Author(s):  
A O Martin ◽  
E L Madsen ◽  
A R Dyer ◽  
L White ◽  
N P Bouck ◽  
...  
Keyword(s):  
Sister Chromatid ◽  
Sister Chromatid Exchange ◽  
Human Cells
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