scholarly journals Recent advances in natural products exploitation in Streptomyces via synthetic biology

2019 ◽  
Vol 19 (6) ◽  
pp. 452-462 ◽  
Author(s):  
Qiyuan Zhao ◽  
Liping Wang ◽  
Yunzi Luo
Keyword(s):  
Natural Products ◽  
Synthetic Biology ◽  
Recent Advances

scholarly journals Applications, challenges, and needs for employing synthetic biology beyond the lab

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Sierra M. Brooks ◽  
Hal S. Alper
Keyword(s):  
Synthetic Biology ◽  
Great Promise ◽  
Long Term Storage ◽  
Autonomous Function ◽  
Recent Advances ◽  
Resource Limited ◽  
Major Application ◽  
Further Development ◽  
Probiotic Delivery

AbstractSynthetic biology holds great promise for addressing global needs. However, most current developments are not immediately translatable to ‘outside-the-lab’ scenarios that differ from controlled laboratory settings. Challenges include enabling long-term storage stability as well as operating in resource-limited and off-the-grid scenarios using autonomous function. Here we analyze recent advances in developing synthetic biological platforms for outside-the-lab scenarios with a focus on three major application spaces: bioproduction, biosensing, and closed-loop therapeutic and probiotic delivery. Across the Perspective, we highlight recent advances, areas for further development, possibilities for future applications, and the needs for innovation at the interface of other disciplines.

Biosynthesis and synthetic biology of psychoactive natural products

2021 ◽  
Author(s):  
Cooper S. Jamieson ◽  
Joshua Misa ◽  
Yi Tang ◽  
John M. Billingsley
Keyword(s):  
Natural Products ◽  
Synthetic Biology ◽  
Biological Activities ◽  
Engineering Applications ◽  
Pathway Discovery

The biosynthetic logic employed by Nature in the construction of psychoactive natural products is reviewed, in addition to biological activities, methodologies enabling pathway discovery, and engineering applications.

scholarly journals Synthetic biology of plant natural products: from pathway elucidation to engineered biosynthesis in plant cells

2021 ◽  
pp. 100229
Author(s):  
Xiaoxi Zhu ◽  
Xiaonan Liu ◽  
Tian Liu ◽  
Yina Wang ◽  
Nida Ahmed ◽  
...  
Keyword(s):  
Natural Products ◽  
Synthetic Biology ◽  
Plant Cells ◽  
Plant Natural Products

ChemInform Abstract: Recent Advances in the Synthesis of Cyclic Polyether Marine Natural Products

ChemInform ◽  
2010 ◽  
Vol 30 (21) ◽  
pp. no-no
Author(s):  
K. C. Nicolaou ◽  
M. H. D. Postema ◽  
N. D. Miller
Keyword(s):  
Natural Products ◽  
Marine Natural Products ◽  
Recent Advances

Recent advances in anti-HIV natural products

2010 ◽  
Vol 27 (12) ◽  
pp. 1781 ◽  
Author(s):  
Inder Pal Singh ◽  
Hardik S. Bodiwala
Keyword(s):  
Natural Products ◽  
Recent Advances ◽  
Anti Hiv

scholarly journals Natural Products and Synthetic Biology: Where We Are and Where We Need To Go

mSystems ◽  
2019 ◽  
Vol 4 (3) ◽  
Author(s):  
Sylvia Kunakom ◽  
Alessandra S. Eustáquio
Keyword(s):  
Natural Products ◽  
Drug Discovery ◽  
Synthetic Biology ◽  
Genome Sequencing ◽  
Scientific Community ◽  
Microbial Metabolites ◽  
Bacterial Genomes ◽  
Cholesterol Lowering

ABSTRACT The biosynthetic talent of microorganisms has been harnessed for drug discovery for almost a century. Microbial metabolites not only account for the majority of antibiotics available today, but have also led to anticancer, immunosuppressant, and cholesterol-lowering drugs. Yet, inherent challenges of natural products—including inadequate supply and difficulties with structure diversification—contributed to their deprioritization as a source of pharmaceuticals. In recent years, advances in genome sequencing and synthetic biology spurred a renewed interest in natural products. Bacterial genomes encode an abundance of natural products awaiting discovery. Synthetic biology can facilitate not only discovery and improvements in supply, but also structure diversification. This perspective highlights prior accomplishments in the field of synthetic biology and natural products by the scientific community at large, including research from our laboratory. We also provide our opinion as to where we need to go to continue advancing the field.

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