B12-independent glycerol dehydratase and its reactivase fromClostridia butyricum: Optimizing cloning by uniform design logic

2015 ◽  
Vol 15 (5) ◽  
pp. 519-524 ◽  
Author(s):  
Wei Jiang ◽  
Shizhen Wang ◽  
Zhongli Yang ◽  
Baishan Fang
Keyword(s):  
Uniform Design ◽  
Glycerol Dehydratase ◽  
Design Logic

Uniform Design Development for School Advertisement - Focused on Ewha Womans University -

2009 ◽  
Vol 17 (5) ◽  
pp. 780-790 ◽  
Author(s):  
Minjung Lee ◽  
이언영 ◽  
LEEINSEONG ◽  
김현정
Keyword(s):  
Uniform Design ◽  
Design Development

scholarly journals Optimization of the extraction and purification of Corydalis yanhusuo W.T. Wang based on the Q-marker uniform design method

BMC Chemistry ◽  
2020 ◽  
Vol 14 (1) ◽  
Author(s):  
Yongping Zhang ◽  
Zuhua Wang ◽  
Jian Xu ◽  
Fangfang Yang ◽  
Chuanyang Dai ◽  
...  
Keyword(s):  
Design Method ◽  
Uniform Design ◽  
Extraction And Purification ◽  
Uniform Design Method

scholarly journals THE LOGICS OF DOUBLE PROOF IN PROOF OF CONCEPT: A DESIGN THEORY-BASED MODEL OF EXPERIMENTATION IN THE UNKNOWN

2021 ◽  
Vol 1 ◽  
pp. 3051-3060
Author(s):  
Caroline Jobin ◽  
Sophie Hooge ◽  
Pascal Le Masson
Keyword(s):  
Design Theory ◽  
Design Framework ◽  
Proof Of Concept ◽  
Design Logic

AbstractThe literature on design distinguishes between exploration-based experimentation and validation-based experimentation. This typology relies on an assumption that exploration and validation cannot and should not be performed simultaneously in the same experimentation. By contrast, some practitioners, such as les Sismo, propose that proof of concept might combine these two logics. This raises the question of what design logic might enable this type of combination of exploration and validation. We first use design theory to build an experimentation design framework. This framework highlights a typology of proof logics in experimentation related to proof of the known and proof of the unknown. Second, we show that these proof models are supported by les Sismo's cases and describe a diversity of arrangements of exploration and validation mechanisms: sequential, parallel, and combinational. Through the formalisation of proof of concept as a double proof (proof of the known and proof of the unknown), we show that proof of concept can be more than a tool for the go/no-go decision by gradually validating propositions, questioning the relevance of propositions, and discovering new propositions to be investigated and tested.

scholarly journals Using uniform design and regression methodology of turning parameters study of nickel alloy

2021 ◽  
Author(s):  
Shao-Hsien Chen ◽  
Chih-Hung Hsu
Keyword(s):  
Surface Roughness ◽  
Tool Wear ◽  
Nickel Alloy ◽  
Design Methodology ◽  
Cutting Tool ◽  
Uniform Design ◽  
Machining Time ◽  
Variable Parameters ◽  
Cutting Test ◽  
Set Up

AbstractThe nickel alloy has good mechanical strength and corrosion resistance at high temperature; it is extensively used in aerospace and biomedical and energy industries, as well as alloy designs of different chemical compositions to achieve different mechanical properties. However, for high mechanical strength, low thermal conductivity, and surface hardening property, the nickel alloy has worse cutting tool life and machining efficiency than general materials. Therefore, how to select the optimum machining parameters will influence the workpiece quality, cost, and machining time. This research will be using a new experimental design methodology to the cutting parameter planning for nickel-based alloy cutting test, and used the uniform design methodology to cutting test to reduce the number of experiments. Three independent variable parameters are set up, including cutting speed, feed rate, and cutting depth, and four dependent variable parameters are set up, including cutting tool wear, surface roughness, machining time, and cutting force. A nickel alloy turning parameter model is built by using regression analysis to further predict the I/O relationship among various combinations of variables. The errors between actual values and prediction values are validated. When the cutting tool wear (VB) is 2.72~6.18%, the surface roughness (Ra) is 4.10~7.72%, the machining time (T) is 3.75~8.82%, and the cutting force (N) is 1.54~7.42%; the errors of various dependent variables are approximately less than 10%, so a high precision estimation model is obtained through a few experiments of uniform design method.

Response of field peas to phosphate fertilization

2003 ◽  
Vol 83 (2) ◽  
pp. 283-289 ◽  
Author(s):  
R. E. Karamanos ◽  
N. A. Flore ◽  
J. T. Harapiak
Keyword(s):  
Uniform Design ◽  
Monoammonium Phosphate ◽  
Canadian Prairie ◽  
Yield Increase ◽  
Seed Moisture ◽  
Field Peas ◽  
Triple Super Phosphate ◽  
Seed Placement ◽  
P Application ◽  
The Impact

Canadian Prairie Provinces in general, and Saskatchewan in particular are major producers of peas worldwide. Individual provincial criteria for P application are considerably different from each other. Further introduction of new pea varieties and the adoption of direct seeding practices prompted us to re-evaluate these criteria. To this end, two experiments with field peas (Pisum sativum L. var. Carneval) were carried out between 1994 and 1998 at nine different locations in Alberta. The first experiment was carried out in 1994 and consisted of three trials with six rates of P (0, 4.4, 8.7, 13, 17.5 and 21.8 kg P ha-1) in the form of monoammonium phosphate (MAP) (12-51-0). To eliminate the impact of varying N rates along with P, a series of 21 trials and a uniform design that included five rates of P (0, 6.5, 13, 19.5 and 26 kg ha-1) in the form of triple super phosphate (0-45-0) and two methods of placement (seed placement or side banding) were subsequently carried out. There was a significant response to P application at all 13 sites of both experiments that contained 10 or less mg of a Modified Kelowna (MK) extractable-P kg-1 of soil. Side banding resulted in significantly higher yield in only three trials. Maximum average yield increase of 645 kg seed ha-1 was obtained with application of 19.5 kg P ha-1; it was influenced by soil texture as the magnitude of response was greater on loamy (535 kg seed ha-1) than on clay loam soils (285 kg seed ha-1). There was no significant yield increase in the trials that contained greater than 10 mg MK-P kg-1 soil. Reduction in plant population was more frequent as a result of seed placement (nine cases with P < 0.1) than side banding in both experiments. The impact of P fertilization on seed moisture was not consistent. The ability to side band or to seed with an increased seed bed utilization may fulfil the need for application of greater rates of P than the ones currently recommended for prairie soils. Key words: Seed placement, side banding, triple super phosphate, monoammonium phosphate

Designing a Future-Ready Enterprise: The Digital Transformation of DBS Bank

2021 ◽  
pp. 000812562199258
Author(s):  
Siew Kien Sia ◽  
Peter Weill ◽  
Nila Zhang
Keyword(s):  
Organizational Design ◽  
Digital Transformation ◽  
Conceptual Clarity ◽  
Exploitation And Exploration ◽  
Design Logic

Many organizations are embarking on digital transformation to be future-ready. However, there is a lack of conceptual clarity on the underlying design logic of a future-ready enterprise. A digitally transformed enterprise must be ready to respond to unpredictable dynamism and pervasive digitalization. Such an enterprise must incorporate the duality of exploitation and exploration as well as the fusion between business and technology into its organizational design. This article presents a framework based on the digital transformation journey of DBS Bank and draws new managerial insights for driving digital transformation strategically.

scholarly journals A preliminary strategy for screening the combination of active components based on Bu–Shen–Yi–Qi Decoction for bronchial asthma

2019 ◽  
Vol 02 (03) ◽  
pp. 135-138
Author(s):  
Chen Yan ◽  
Qingli Luo ◽  
Cheng Ma ◽  
Jiaqi Liu ◽  
Jingcheng Dong
Keyword(s):  
Regression Analysis ◽  
Bronchial Asthma ◽  
Molecular Mechanisms ◽  
Uniform Design ◽  
Chinese Herbs ◽  
Chinese Drug ◽  
Active Components ◽  
Control Drug ◽  
Effective Components ◽  
Herba Epimedii

Objective: The anti-asthma herbal medicine Bu–Shen–Yi–Qi Decoction (BSYQ Decoction), a combination of three traditional Chinese medicine herbs developed in our lab, has shown demonstrated efficacy in Ovalbumin (OVA)-induced acute bronchial asthma. However, the obscure substances, multiple potential targets and the unclear molecular mechanisms are obstacles to control drug quality, stability and standardization. Multi-component formulae with a clear pharmacodynamic material and specific mechanism are an innovation worth exploring. They may also partly reserve a potential synergistic and additive effect compared with single components extracted from traditional Chinese herbs. This study was designed to select three standard multi-component formulae of the combination of effective components preliminarily based on four effective components [total flavonoids of Herba Epimedii ([Formula: see text]; Astragalus polysaccharide ([Formula: see text]; Astragaloside ([Formula: see text]; and Catalpol ([Formula: see text]] in BSYQ Decoction. Methods: OVA-induced asthmatic murine models were established. A uniform design was applied to select 10 proportions from four target components, and 3 formulae which showed best effect aimed at IFN-[Formula: see text], IL-4 and IgE in the serum respectively were screened based on stepwise regression analysis. Results: According to the regression analysis, Formula I ([Formula: see text]:[Formula: see text]:[Formula: see text]:6:29), Formula II ([Formula: see text]:[Formula: see text]:[Formula: see text]:8:2) and Formula III ([Formula: see text]:[Formula: see text]:[Formula: see text]:[Formula: see text]:50:8:2) are the three potential proper ratios for the new multi-component formula aimed at serum IFN-[Formula: see text], IL-4 and IgE in OVA-induced asthma mice, respectively. Conclusion: Three multi-component formulae derived from BSYQ Decoction could exert anti-inflammatory effect against OVA-induced asthma, which might provide evidences and lay foundations for further study of standard modern Chinese drug for treating asthma based on BSYQ Decoction.

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