scholarly journals The behavior of carboxylated and hydroxylated polythiophene as bioreceptor layer: Anti‐human IgG and human IgG interaction detection based on organic electrochemical transistors

2021 ◽  
Author(s):  
Yunjia Song ◽  
Justine Wagner ◽  
Howard E. Katz
Keyword(s):  
Human Igg ◽  
Interaction Detection ◽  
Organic Electrochemical Transistors

PENERAPAN CHAID DENGAN PENDEKATAN SMOTE PADA KEMATIAN BALITA DI KAWASAN TIMUR INDONESIA TAHUN 2017

2020 ◽  
Vol 2019 (1) ◽  
pp. 357-367
Author(s):  
Isti Samrotul Hidayati ◽  
I Made Arcana
Keyword(s):  
Sampling Technique ◽  
Chi Square ◽  
Interaction Detection ◽  
Chi Squared

Metode Chi-squared Automatic Interaction Detection (CHAID) merupakan metode segmentasi berdasarkan hubungan variabel respon dan penjelas menggunakan uji chi-square, yang dalam penerapannya perlu memperhatikan keseimbangan data untuk meminimalkan kesalahan dalam klasifikasi. Salah satu pendekatan yang dapat digunakan pada data yang tidak seimbang adalah metode Synthetic Minority Over-sampling Technique (SMOTE). Dalam penelitian ini, metode CHAID dengan pendekatan SMOTE diterapkan pada Angka Kematian Balita (AKBa) di Kawasan Timur Indonesia (KTI). Tujuannya adalah untuk mengetahui variabel-variabel yang mencirikan kematian balita berdasarkan metode analisis CHAID yang diterapkan dan membandingkannya dengan pendekatan SMOTE. Hasil perbandingan menunjukkan bahwa pendekatan SMOTE lebih baik digunakan dengan nilai sensitivitas sebesar 48,3% dan nilai presisi sebesar 75,9%. Variabel yang signifikan mencirikan kematian balita di KTI adalah berat badan saat lahir, jenis kelahiran, status bekerja ibu dan kekayaan rumah tangga, dengan karakteristik utama adalah balita yang memiliki berat badan lahir rendah dan terlahir kembar.

Improved human-object interaction detection through skeleton-object relations

2020 ◽  
pp. 1-12
Author(s):  
Hong-Bo Zhang ◽  
Yi-Zhong Zhou ◽  
Ji-Xiang Du ◽  
Jin-Long Huang ◽  
Qing Lei ◽  
...  
Keyword(s):  
Object Relations ◽  
Interaction Detection ◽  
Object Interaction ◽  
Human Object

scholarly journals Pharmaceutical immunoglobulin G impairs anti-carcinoma activity of oxaliplatin in colon cancer cells

2021 ◽  
Author(s):  
Yuru Shang ◽  
Xianbin Zhang ◽  
Lili Lu ◽  
Ke Jiang ◽  
Mathias Krohn ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cell Viability ◽  
Cancer Patients ◽  
Cell Lines ◽  
Cancer Cell ◽  
Immunoglobulin G ◽  
Cancer Cell Lines ◽  
Human Igg ◽  
Western Blots ◽  
Igg Receptors

Abstract Background Recent evidence proves that intravenous human immunoglobulin G (IgG) can impair cancer cell viability. However, no study evaluated whether IgG application benefits cancer patients receiving chemotherapeutics. Methods Influence of pharmaceutical-grade human IgG on the viability of a series of patient-derived colon cancer cell lines with and without chemotherapeutic intervention was determined. Cell death was analysed flow cytometrically. In addition, the influence of oxaliplatin and IgG on the ERK1/2-signalling pathway was evaluated by western blots. Results We evaluated the effects of pharmaceutical IgG, such as PRIVIGEN® IgG and Tonglu® IgG, in combination with chemotherapeutics. We did not observe any significant effects of IgG on tumour cell viability directly; however, human IgG significantly impaired the anti-tumoral effects of oxaliplatin. Primary cancer cell lines express IgG receptors and accumulate human IgG intracellularly. Moreover, while oxaliplatin induced the activation of ERK1/2, the pharmaceutical IgG inhibited ERK1/2 activity. Conclusions The present study demonstrates that pharmaceutical IgG, such as PRIVIGEN® IgG and Tonglu® IgG, can impair the anti-carcinoma activity of oxaliplatin. These data strongly suggest that therapeutic IgG as co-medication might have harmful side effects in cancer patients. The clinical significance of these preclinical observations absolutely advises further preclinical, as well as epidemiological and clinical research.

Single‐Component CMOS‐Like Logic using Diketopyrrolopyrrole‐Based Ambipolar Organic Electrochemical Transistors

2021 ◽  
pp. 2102903
Author(s):  
Jibin J. Samuel ◽  
Ashutosh Garudapalli ◽  
Aiswarya Abhisek Mohapatra ◽  
Chandrasekhar Gangadharappa ◽  
Satish Patil ◽  
...  
Keyword(s):  
Single Component ◽  
Organic Electrochemical Transistors
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