Panel of serum protein biomarkers to grade the severity of traumatic brain injury

2018 ◽  
Vol 39 (18) ◽  
pp. 2308-2315 ◽  
Author(s):  
Raj Poovindran Anada ◽  
Kum Thong Wong ◽  
Jaime Jacqueline Jayapalan ◽  
Onn Haji Hashim ◽  
Dharmendra Ganesan
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Serum Protein ◽  
Protein Biomarkers

scholarly journals Characteristics of patients included and enrolled in studies on the prognostic value of serum biomarkers for prediction of postconcussion symptoms following a mild traumatic brain injury: a systematic review

BMJ Open ◽  
2017 ◽  
Vol 7 (9) ◽  
pp. e017848 ◽  
Author(s):  
Eric Mercier ◽  
Pier-Alexandre Tardif ◽  
Marcel Emond ◽  
Marie-Christine Ouellet ◽  
Élaine de Guise ◽  
...  
Keyword(s):  
Systematic Review ◽  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Serum Protein ◽  
Mild Traumatic Brain Injury ◽  
Prognostic Value ◽  
Protein Biomarkers ◽  
Exclusion Criteria ◽  
Evaluation Approach ◽  
Postconcussion Symptoms

ObjectiveMild traumatic brain injury (mTBI) has been insufficiently researched, and its definition remains elusive. Investigators are confronted by heterogeneity in patients, mechanism of injury and outcomes. Findings are thus often limited in generalisability and clinical application. Serum protein biomarkers are increasingly assessed to enhance prognostication of outcomes, but their translation into clinical practice has yet to be achieved. A systematic review was performed to describe the adult populations included and enrolled in studies that evaluated the prognostic value of protein biomarkers to predict postconcussion symptoms following an mTBI.Data sourcesSearches of MEDLINE, Embase, CENTRAL, CINAHL, Web of Science, PsycBITE and PsycINFO up to October 2016.Data selection and extractionTwo reviewers independently screened for potentially eligible studies, extracted data and assessed the overall quality of evidence by outcome using the Grading of Recommendations Assessment, Development and Evaluation approach.ResultsA total of 23 298 citations were obtained from which 166 manuscripts were reviewed. Thirty-six cohort studies (2812 patients) having enrolled between 7 and 311 patients (median 89) fulfilled our inclusion criteria. Most studies excluded patients based on advanced age (n=10 (28%)), neurological disorders (n=20 (56%)), psychiatric disorders (n=17 (47%)), substance abuse disorders (n=13 (36%)) or previous traumatic brain injury (n=10 (28%)). Twenty-one studies (58%) used at least two of these exclusion criteria. The pooled mean age of included patients was 39.3 (SD 4.6) years old (34 studies). The criteria used to define a mTBI were inconsistent. The most frequently reported outcome was postconcussion syndrome using the Rivermead Post-Concussion Symptoms Questionnaire (n=18 (50%)) with follow-ups ranging from 7 days to 5 years after the mTBI.ConclusionsMost studies have recruited samples that are not representative and generalisable to the mTBI population. These exclusion criteria limit the potential use and translation of promising serum protein biomarkers to predict postconcussion symptoms.

scholarly journals Serial Sampling of Serum Protein Biomarkers for Monitoring Human Traumatic Brain Injury Dynamics: A Systematic Review

2017 ◽  
Vol 8 ◽  
Author(s):  
Eric Peter Thelin ◽  
Frederick Adam Zeiler ◽  
Ari Ercole ◽  
Stefania Mondello ◽  
András Büki ◽  
...  
Keyword(s):  
Systematic Review ◽  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Serum Protein ◽  
Protein Biomarkers ◽  
Serial Sampling

Serum Protein Biomarkers in the Management of Severe Traumatic Brain Injury

2020 ◽  
pp. 343-355
Author(s):  
Eric Peter Thelin ◽  
David W. Nelson ◽  
Johan Undén ◽  
Ramona Åstrand ◽  
Bo-Michael Bellander
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Serum Protein ◽  
Severe Traumatic Brain Injury ◽  
Protein Biomarkers

Detection of Traumatic Brain Injury Protein Biomarkers With Resonant Microsystems

2017 ◽  
Vol 1 (6) ◽  
pp. 1-4 ◽  
Author(s):  
Michael J. Wadas ◽  
Mackenzie Tweardy ◽  
Nikhil Bajaj ◽  
Allison K. Murray ◽  
George T.-C. Chiu ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Protein Biomarkers

scholarly journals Serum miR-502: A potential biomarker in the diagnosis of concussion in a pilot study of patients with normal structural brain imaging

2019 ◽  
Vol 3 ◽  
pp. 205970021988619
Author(s):  
David Davies ◽  
Kamal M Yakoub ◽  
Ugo Scarpa ◽  
Connor Bentley ◽  
Michael Grey ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Pilot Study ◽  
Glial Fibrillary Acid Protein ◽  
Protein Biomarkers ◽  
Neurofilament Light ◽  
Acid Protein ◽  
Moderate Traumatic Brain Injury ◽  
Carboxy Terminal ◽  
Potential Biomarkers

Establishing a diagnosis of concussion within the context of competitive sport is frequently difficult due to the heterogeneity of presentation. Over the years, many endogenous proteins, including the recent Food and Drug Administration approved for mild-to-moderate traumatic brain injury, glial fibrillary acid protein and ubiquitin carboxy-terminal hydrolase, have been studied as potential biomarkers for the diagnosis of mild traumatic brain injury. Recently, a new class of potential biomarkers, the microRNAs, has shown promise as indicators of traumatic brain injury. In this pilot study, we have analysed the ability of pre-validated serum microRNAs (mi-425-5p and miR-502) to diagnose concussion, in cases without structural pathology. Their performance has been assessed alongside a set of identified protein biomarkers for traumatic brain injury in cohort of 41 concussed athletes. Athletes with a confirmed concussion underwent blood sampling after 48 h from concussion along with magnetic resonance imaging. Serum mi-425-5p and miR-502 were analysed by quantitative reverse transcription polymerase chain reaction, and digital immunoassay was used to determine serum concentrations of ubiquitin carboxy-terminal hydrolase, glial fibrillary acid protein, neurofilament light and Tau. Results were matched with 15 healthy volunteers. No structural/haemorrhagic pathology was identified. Protein biomarkers demonstrated variability among groups reflecting previous performance in the literature. Neurofilament light was the only marker to positively correlate with symptoms reported and SCAT5 scores. Despite the sub optimal timing of sampling beyond the optimal window for many of the protein biomarkers measured, miR-502 was significantly downregulated at all time points within a week form concussion ictus, showing a diagnostic sensitivity in cases beyond 48 h and without structural pathology.

scholarly journals Protein Biomarkers and Neuroproteomics Characterization of Microvesicles/Exosomes from Human Cerebrospinal Fluid Following Traumatic Brain Injury

2017 ◽  
Vol 55 (7) ◽  
pp. 6112-6128 ◽  
Author(s):  
Rachna Manek ◽  
Ahmed Moghieb ◽  
Zhihui Yang ◽  
Dhwani Kumar ◽  
Firas Kobessiy ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Cerebrospinal Fluid ◽  
Brain Injury ◽  
Protein Biomarkers ◽  
Human Cerebrospinal Fluid

scholarly journals Elevated Serum Protein S100B and Neuron Specific Enolase Values as Predictors of Early Neurological Outcome after Traumatic Brain Injury

2017 ◽  
Vol 36 (4) ◽  
pp. 314-321 ◽  
Author(s):  
Branislava Stefanović ◽  
Olivera Đurić ◽  
Sanja Stanković ◽  
Srđan Mijatović ◽  
Krstina Doklestić ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Serum Protein ◽  
Neurological Outcome ◽  
Brain Injuries ◽  
Elevated Serum ◽  
Neuron Specific Enolase ◽  
Poor Outcome ◽  
Protein S100b ◽  
The Brain

SummaryBackground: The objective of our study was to determine the serum concentrations of protein S100B and neuron specific enolase (NSE) as well as their ability and accuracy in the prediction of early neurological outcome after a traumatic brain injury. Methods: A total of 130 polytraumatized patients with the associated traumatic brain injuries were included in this prospective cohort study. Serum protein S100B and NSE levels were measured at 6, 24, 48 and 72 hours after the injury. Early neurological outcome was scored by Glasgow Outcome Scale (GOS) on day 14 after the brain injury. Results: The protein S100B concentrations were maximal at 6 hours after the injury, which was followed by an abrupt fall, and subsequently slower release in the following two days with continual and significantly increased values (p<0.0001) in patients with poor outcome. Secondary increase in protein S100B at 72 hours was recorded in patients with lethal outcome (GOS 1). Dynamics of NSE changes was characterized by a secondary increase in concentrations at 72 hours after the injury in patients with poor outcome. Conclusion: Both markers have good predictive ability for poor neurological outcome, although NSE provides better discriminative potential at 72 hours after the brain injury, while protein S100B has better discriminative potential for mortality prediction.

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