Enantioseparation of α-hydroxy acids by chiral ligand exchange CE with a dual central metal ion system

2012 ◽  
Vol 33 (18) ◽  
pp. 2920-2924 ◽  
Author(s):  
Shuji Kodama ◽  
Atsushi Yamamoto ◽  
Sen-ichi Aizawa ◽  
Yoshitaka Honda ◽  
Kentaro Suzuki ◽  
...  
Keyword(s):  
Ligand Exchange ◽  
Metal Ion ◽  
Chiral Ligand ◽  
Central Metal ◽  
Hydroxy Acids ◽  
Chiral Ligand Exchange

scholarly journals Polydopamine-Assisted Rapid One-Step Immobilization of L-Arginine in Capillary as Immobilized Chiral Ligands for Enantioseparation of Dansyl Amino Acids by Chiral Ligand Exchange Capillary Electrochromatography

Molecules ◽  
2021 ◽  
Vol 26 (6) ◽  
pp. 1800
Author(s):  
Yuanqi Gui ◽  
Baian Ji ◽  
Gaoyi Yi ◽  
Xiuju Li ◽  
Kailian Zhang ◽  
...  
Keyword(s):  
Amino Acids ◽  
Ligand Exchange ◽  
Capillary Electrochromatography ◽  
Metal Ion ◽  
High Performance ◽  
Basic Amino Acid ◽  
Chiral Ligand ◽  
Central Metal ◽  
Dansyl Amino Acids ◽  
Chiral Ligand Exchange

Herein, a novel L-arginine (L-Arg)-modified polydopamine (PDA)-coated capillary (PDA/L-Arg@capillary) was firstly fabricated via the basic amino-acid-induced PDA co-deposition strategy and employed to constitute a new chiral ligand exchange capillary electrochromatography (CLE-CEC) method for the high-performance enantioseparation of D,L-amino acids (D,L-AAs) with L-Arg as the immobilized chiral ligand coordinating with the central metal ion Zn(II) as running buffer. Assisted by hydrothermal treatment, the robust immobilization of L-Arg on the capillary inner wall could be facilely achieved within 1 h, prominently improving the synthesis efficiency and simplifying the preparation procedure. The successful preparation of PDA/L-Arg coatings in the capillary was systematically characterized and confirmed using several methods. In comparison with bare and PDA-functionalized capillaries, the enantioseparation capability of the presented CLE-CEC system was significantly enhanced. Eight D,L-AAs were completely separated and three pairs were partially separated under the optimal conditions. The prepared PDA/L-Arg@capillary showed good repeatability and stability. The potential mechanism of the greatly enhanced enantioseparation performance obtained by PDA/L-Arg@capillary was also explored. Moreover, the proposed method was further utilized for studying the enzyme kinetics of L-glutamic dehydrogenase, exhibiting its promising prospects in enzyme assays and other related applications.

Determination of α-hydroxy acids and their enantiomers in fruit juices by ligand exchange CE with a dual central metal ion system

2013 ◽  
Vol 34 (9-10) ◽  
pp. 1327-1333 ◽  
Author(s):  
Shuji Kodama ◽  
Sen-ichi Aizawa ◽  
Atsushi Taga ◽  
Atsushi Yamamoto ◽  
Yoshitaka Honda ◽  
...  
Keyword(s):  
Ligand Exchange ◽  
Metal Ion ◽  
Fruit Juices ◽  
Central Metal ◽  
Hydroxy Acids

Separation of fudosteine on an achiral C18column by HPLC with chiral ligand-exchange selectors as mobile phase additives

2008 ◽  
Vol 20 (4) ◽  
pp. 585-594 ◽  
Author(s):  
J. Ma ◽  
J. Cao ◽  
M. J. Ding ◽  
L. H. Yuan ◽  
M. J. Zhai ◽  
...  
Keyword(s):  
Ligand Exchange ◽  
Mobile Phase ◽  
Chiral Ligand ◽  
Mobile Phase Additives ◽  
Chiral Ligand Exchange

Chitosan chiral ligand exchange membranes for sorption resolution of amino acids

2009 ◽  
Vol 64 (7) ◽  
pp. 1462-1473 ◽  
Author(s):  
Hai-Dong Wang ◽  
Rui Xie ◽  
Catherine Hui Niu ◽  
Hang Song ◽  
Mei Yang ◽  
...  
Keyword(s):  
Amino Acids ◽  
Ligand Exchange ◽  
Chiral Ligand ◽  
Chiral Ligand Exchange

Isoleucine ionic liquids as additives to separate mandelic acid and their derivative enantiomers by HPLC

2014 ◽  
Vol 6 (15) ◽  
pp. 5627-5631 ◽  
Author(s):  
Jie Zhou ◽  
Suzhen Zhao ◽  
Guangjun Fu ◽  
Zhenzhong Zhang
Keyword(s):  
Ionic Liquids ◽  
Ligand Exchange ◽  
Mandelic Acid ◽  
Exchange Chromatography ◽  
Chiral Ligands ◽  
Chiral Ligand ◽  
Ligand Exchange Chromatography ◽  
Chiral Ligand Exchange

In this study, functional isoleucine ionic liquids were synthesized and used as novel chiral ligands coordinated with Cu(ii) in chiral ligand exchange chromatography.

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