Profiling of Endo H-released serum N-glycans using CE-LIF and MALDI-TOF-MS - Application to rheumatoid arthritis

2011 ◽  
Vol 32 (24) ◽  
pp. 3510-3515 ◽  
Author(s):  
Elena Frisch ◽  
Matthias Kaup ◽  
Karl Egerer ◽  
Andreas Weimann ◽  
Rudolf Tauber ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Maldi Tof Ms ◽  
Maldi Tof ◽  
Tof Ms

scholarly journals Serum Peptidomic Profile as a Novel Biomarker for Rheumatoid Arthritis

2020 ◽  
Vol 2020 ◽  
pp. 1-10
Author(s):  
Abeer A. Abdelati ◽  
Rehab A. Elnemr ◽  
Noha S. Kandil ◽  
Fatma I. Dwedar ◽  
Rasha A. Ghazala
Keyword(s):  
Rheumatoid Arthritis ◽  
Profile Analysis ◽  
Magnetic Bead ◽  
Response To Treatment ◽  
Healthy Controls ◽  
Protein Biomarkers ◽  
Maldi Tof Ms ◽  
Maldi Tof ◽  
Flight Mass Spectrometry ◽  
Tof Ms

Over the last decades, there has been an increasing need to discover new diagnostic RA biomarkers, other than the current serologic biomarkers, which can assist early diagnosis and response to treatment. The purpose of this study was to analyze the serum peptidomic profile in patients with rheumatoid arthritis (RA) by using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF-MS). The study included 35 patients with rheumatoid arthritis (RA), 35 patients with primary osteoarthritis (OA) as the disease control (DC), and 35 healthy controls (HC). All participants were subjected to serum peptidomic profile analysis using magnetic bead (MB) separation (MALDI-TOF-MS). The trial showed 113 peaks that discriminated RA from OA and 101 peaks that discriminated RA from HC. Moreover, 95 peaks were identified and discriminated OA from HC; 38 were significant (p<0.05) and 57 nonsignificant. The genetic algorithm (GA) model showed the best sensitivity and specificity in the three trials (RA versus HC, OA versus HC, and RA versus OA). The present data suggested that the peptidomic pattern is of value for differentiating individuals with RA from OA and healthy controls. We concluded that MALDI-TOF-MS combined with MB is an effective technique to identify novel serum protein biomarkers related to RA.

Discovery of serum protein biomarkers in rheumatoid arthritis using MALDI-TOF-MS combined with magnetic beads

2011 ◽  
Vol 12 (3) ◽  
pp. 145-151 ◽  
Author(s):  
Xiaoxue Zhang ◽  
Zhaolin Yuan ◽  
Bo Shen ◽  
Min Zhu ◽  
Chibo Liu ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Serum Protein ◽  
Magnetic Beads ◽  
Protein Biomarkers ◽  
Maldi Tof Ms ◽  
Maldi Tof ◽  
Tof Ms

scholarly journals Specific serum protein biomarkers of rheumatoid arthritis detected by MALDI-TOF-MS combined with magnetic beads

2010 ◽  
Vol 22 (7) ◽  
pp. 611-618 ◽  
Author(s):  
Q. Niu ◽  
Z. Huang ◽  
Y. Shi ◽  
L. Wang ◽  
X. Pan ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Serum Protein ◽  
Magnetic Beads ◽  
Protein Biomarkers ◽  
Maldi Tof Ms ◽  
Maldi Tof ◽  
Specific Serum ◽  
Tof Ms

895: Proteomic Analysis of Sera from Bladder Cancer Patients with MALDI-TOF-MS

2007 ◽  
Vol 177 (4S) ◽  
pp. 297-297
Author(s):  
Kristina Schwamborn ◽  
Rene Krieg ◽  
Ruth Knüchel-Clarke ◽  
Joachim Grosse ◽  
Gerhard Jakse
Keyword(s):  
Bladder Cancer ◽  
Cancer Patients ◽  
Proteomic Analysis ◽  
Maldi Tof Ms ◽  
Maldi Tof ◽  
Tof Ms

HPTLC-MALDI/TOF/MS vs. HPLC-ESI/MS2 for identification to flavonoids in plant extracts

Planta Medica ◽  
2016 ◽  
Vol 81 (S 01) ◽  
pp. S1-S381
Author(s):  
L Fougère ◽  
D Da Silva ◽  
E Destandau ◽  
C Elfakir
Keyword(s):  
Plant Extracts ◽  
Maldi Tof Ms ◽  
Maldi Tof ◽  
Tof Ms

Infektionserreger beim Schwein – Analyse des kultivierbaren Mikrobioms mittels MALDI-TOF MS

2017 ◽  
Author(s):  
M Erhard ◽  
M Metzner ◽  
D Köhler-Repp ◽  
B Köhler ◽  
R Storandt
Keyword(s):  
Maldi Tof Ms ◽  
Maldi Tof ◽  
Tof Ms

Quantitative metabolomics of Iranian saffron based on their HPLC-DAD and MALDI-TOF-MS

2019 ◽  
Author(s):  
M Hooshyari ◽  
H Rezadoost ◽  
P Ghezellou ◽  
A Ghassempour
Keyword(s):  
Maldi Tof Ms ◽  
Quantitative Metabolomics ◽  
Maldi Tof ◽  
Tof Ms
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