Functionalized carbon nanotubes as the pseudostationary phase for capillary EKC separation of non-steroidal anti-inflammatory drugs

2009 ◽  
Vol 30 (22) ◽  
pp. 3964-3970 ◽  
Author(s):  
Yi-Jin Huang ◽  
Guan-Ren Wang ◽  
Kuan-Pin Huang ◽  
Yu-Fang Hsieh ◽  
Chuen-Ying Liu
Keyword(s):  
Carbon Nanotubes ◽  
Functionalized Carbon Nanotubes ◽  
Pseudostationary Phase ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

Front Cover: Magnetic multi-walled carbon nanotubes as a valuable option for the preconcentration of non-steroidal anti-inflammatory drugs in water

2018 ◽  
Vol 1 (8) ◽  
pp. NA-NA
Author(s):  
Feras Abujaber ◽  
Laura Avendaño ◽  
Shehdeh Jodeh ◽  
Ángel Ríos ◽  
Francisco Javier Guzmán Bernardo ◽  
...  
Keyword(s):  
Carbon Nanotubes ◽  
Front Cover ◽  
Multi Walled Carbon Nanotubes ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Walled Carbon Nanotubes

Magnetic multi-walled carbon nanotubes as a valuable option for the preconcentration of non-steroidal anti-inflammatory drugs in water

2018 ◽  
Vol 1 (8) ◽  
pp. 549-555 ◽  
Author(s):  
Feras Abujaber ◽  
Laura Avendaño ◽  
Shehdeh Jodeh ◽  
Ángel Ríos ◽  
Francisco Javier Guzmán Bernardo ◽  
...  
Keyword(s):  
Carbon Nanotubes ◽  
Multi Walled Carbon Nanotubes ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Walled Carbon Nanotubes

scholarly journals Facile Method to Prepare pH-Sensitive PEI-Functionalized Carbon Nanotubes as Rationally Designed Vehicles for Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) Delivery

2020 ◽  
Vol 6 (4) ◽  
pp. 62
Author(s):  
Vassilis Tangoulis ◽  
Nikolia Lalioti ◽  
John Parthenios ◽  
Nathan Langford ◽  
Eugenia Valsami-Jones ◽  
...  
Keyword(s):  
Carbon Nanotubes ◽  
Drug Release ◽  
Electrostatic Interactions ◽  
Fluorescence Emission ◽  
Ph Sensitive ◽  
Vis Spectroscopy ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Ct Dna

A new pH-sensitive system designed for drug-delivery purposes and based on functionalized multiwall magnetic carbon nanotubes (Mag-CNTs) was synthesized for the effective incorporation of non-steroidal anti-inflammatory drugs (NSAIDs), aiming at drug release in characteristic acidic conditions close to the actual conditions of inflamed tissues. Cationic hyperbranched polyethyleneimine (PEI) was immobilized on the surface of Mag-CNTs via electrostatic interactions between the positively charged protonated amines within the polymer and the carboxyl groups on the chemically oxidized Mag-CNT surface. The addition of the NSAID with a carboxylate donor, Naproxen (NAP), was achieved by indirect coupling through the amino groups of the intermediate linker PEI. FT-IR, Raman, and UV–vis spectroscopy were employed to fully characterize the synthesized nanocarrier and its functionalization procedure. The interaction of the designed nanocarrier with bovine serum albumin (BSA) was studied in vitro by fluorescence emission spectroscopy while its in vitro interaction with calf-thymus (CT) DNA was monitored by UV–vis spectroscopy and viscosity measurements and via competitive studies with ethidium bromide. The calculated binding constants were compared to those of free NAP revealing a higher binding affinity for BSA and CT DNA. Finally, drug-release studies were performed, revealing that the electrostatic linkage ensures an effective release of the drug in the acidic pH typical of inflamed cells, while maintaining the multiwall nanotubes (MWNTs)–drug conjugates stable at the typical bloodstream.

Polyphenols from Cymbopogon citratus inhibit iNOS expression and NO production – a promising source of new anti-inflammatory drugs

Planta Medica ◽  
2010 ◽  
Vol 76 (12) ◽  
Author(s):  
V Francisco ◽  
A Figueirinha ◽  
B Neves ◽  
C Garcia-Rodriguez ◽  
M Lopes ◽  
...  
Keyword(s):  
Inos Expression ◽  
No Production ◽  
Cymbopogon Citratus ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Promising Source

Heparin and proteoglycans as anti-inflammatory drugs

1996 ◽  
Vol 16 (01) ◽  
pp. 56-59
Author(s):  
D. J. Tyrrell ◽  
C. P. Page
Keyword(s):  
Inflammatory Diseases ◽  
Therapeutic Applications ◽  
Wide Range ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

SummaryEvidence continues to accumulate that the pleiotropic nature of heparin (beyond its anticoagulant potency) includes anti-inflammatory activities at a number of levels. It is clear that drugs exploiting these anti-inflammatory activities of heparin may offer exciting new therapeutic applications to the treatment of a wide range of inflammatory diseases.

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