Selectivity of quadruplex DNA stationary phases toward amino acids in homodipeptides and alanyl dipeptides

2004 ◽  
Vol 25 (9) ◽  
pp. 1230-1236 ◽  
Author(s):  
Trang U. Vo ◽  
Linda B. McGown
Keyword(s):  
Amino Acids ◽  
Stationary Phases ◽  
Quadruplex Dna ◽  
Alanyl Dipeptides

scholarly journals Recent Advances in Chiral Analysis of Proteins and Peptides

Separations ◽  
2021 ◽  
Vol 8 (8) ◽  
pp. 112
Author(s):  
Marine Morvan ◽  
Ivan Mikšík
Keyword(s):  
Amino Acids ◽  
Stationary Phases ◽  
Enzymatic Digestion ◽  
Chiral Separations ◽  
Biological Compounds ◽  
Health And Disease ◽  
Electrophoretic Techniques ◽  
A Site ◽  
Future Work ◽  
Proteins And Peptides

Like many biological compounds, proteins are found primarily in their homochiral form. However, homochirality is not guaranteed throughout life. Determining their chiral proteinogenic sequence is a complex analytical challenge. This is because certain D-amino acids contained in proteins play a role in human health and disease. This is the case, for example, with D-Asp in elastin, β-amyloid and α-crystallin which, respectively, have an action on arteriosclerosis, Alzheimer's disease and cataracts. Sequence-dependent and sequence-independent are the two strategies for detecting the presence and position of D-amino acids in proteins. These methods rely on enzymatic digestion by a site-specific enzyme and acid hydrolysis in a deuterium or tritium environment to limit the natural racemization of amino acids. In this review, chromatographic and electrophoretic techniques, such as LC, SFC, GC and CE, will be recently developed (2018–2020) for the enantioseparation of amino acids and peptides. For future work, the discovery and development of new chiral stationary phases and derivatization reagents could increase the resolution of chiral separations.

Influence of silica functionalization by amino acids and peptides on the stationary phases zeta potential

2018 ◽  
Vol 1573 ◽  
pp. 98-106 ◽  
Author(s):  
Magdalena Skoczylas ◽  
Szymon Bocian ◽  
Bogusław Buszewski
Keyword(s):  
Amino Acids ◽  
Zeta Potential ◽  
Stationary Phases

Enantioseparation of racemic 4-aryl-3,4-dihydro-2(1H)-pyrimidones on chiral stationary phases based on 3,5-dimethylanilides ofN-(4-alkylamino-3,5-dinitro)benzoyl L-?-amino acids

Chirality ◽  
2003 ◽  
Vol 15 (6) ◽  
pp. 550-557 ◽  
Author(s):  
Darko Kontrec ◽  
Vladimir Vinkovi? ◽  
Vitomir ?unji? ◽  
Birgit Schuiki ◽  
Walter M.F. Fabian ◽  
...  
Keyword(s):  
Amino Acids ◽  
Stationary Phases ◽  
Chiral Stationary Phases

Liquid chromatographic enantioseparation of limonene-based carbocyclic β-amino acids on zwitterionic Cinchona alkaloid-based chiral stationary phases

2017 ◽  
Vol 40 (16) ◽  
pp. 3196-3204 ◽  
Author(s):  
Gyula Lajkó ◽  
Tímea Orosz ◽  
Imre Ugrai ◽  
Zsolt Szakonyi ◽  
Ferenc Fülöp ◽  
...  
Keyword(s):  
Amino Acids ◽  
Stationary Phases ◽  
Chiral Stationary Phases ◽  
Cinchona Alkaloid ◽  
Liquid Chromatographic

The role of π-acidic and π-basic chiral stationary phases in the high-performance liquid chromatographic enantioseparation of unusual β-amino acids

Chirality ◽  
2009 ◽  
Vol 21 (3) ◽  
pp. 339-348 ◽  
Author(s):  
István Ilisz ◽  
Róbert Berkecz ◽  
Enikő Forró ◽  
Ferenc Fülöp ◽  
Daniel W. Armstrong ◽  
...  
Keyword(s):  
Amino Acids ◽  
High Performance ◽  
Stationary Phases ◽  
Chiral Stationary Phases ◽  
High Performance Liquid Chromatographic ◽  
Liquid Chromatographic
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