Single-isomer sulfatedα-cyclodextrins for capillary electrophoresis. Part 2. Hexakis(6-O-sulfo)-α-cyclodextrin: Synthesis, analytical characterization, and initial screening tests

2004 ◽  
Vol 25 (9) ◽  
pp. 1201-1210 ◽  
Author(s):  
Shulan Li ◽  
Gyula Vigh
Keyword(s):  
Capillary Electrophoresis ◽  
Screening Tests ◽  
Initial Screening ◽  
Analytical Characterization ◽  
Single Isomer

Newborn Screening for Cystic Fibrosis

PEDIATRICS ◽  
1991 ◽  
Vol 87 (6) ◽  
pp. 954-955
Author(s):  
IAN C. T. LYON ◽  
DIANNE R. WEBSTER
Keyword(s):  
Cystic Fibrosis ◽  
Newborn Screening ◽  
Elevated Level ◽  
Meconium Ileus ◽  
Screening Tests ◽  
Initial Screening ◽  
False Negatives ◽  
Immunoreactive Trypsinogen

To the Editor.— The report on newborn screening for cystic fibrosis1 illustrates the need for continued evaluation of such programs. The authors state that the identification of cases of cystic fibrosis (CF) by an elevated level of immunoreactive trypsinogen (IRT) in second (follow-up) samples from infants with positive initial screening tests could result in false negatives in 27% of cases of cystic fibrosis without meconium ileus (MI). We have screened 401 122 infants using the method originally reported.2

scholarly journals Single isomer cyclodextrins as chiral selectors in capillary electrophoresis

2020 ◽  
Vol 1627 ◽  
pp. 461375
Author(s):  
Ida Fejős ◽  
Eszter Kalydi ◽  
Milo Malanga ◽  
Gábor Benkovics ◽  
Szabolcs Béni
Keyword(s):  
Capillary Electrophoresis ◽  
Chiral Selectors ◽  
Single Isomer

Urinary Oestrogen and Plasma Human Placental Lactogen as Initial Screening Tests for a Placental Sulphatase Deficiency

1976 ◽  
Vol 21 (3) ◽  
pp. 106-108 ◽  
Author(s):  
G. H. Beastall ◽  
Anne M. Kelly ◽  
P. England ◽  
L. G. S. Rao ◽  
Margaret W. Macgregor ◽  
...  
Keyword(s):  
Enzyme Activities ◽  
Routine Screening ◽  
In Vitro Studies ◽  
Placental Lactogen ◽  
Screening Tests ◽  
Human Placental Lactogen ◽  
Initial Screening

As a result of routine screening of ante-natal patients by urinary total oestrogens and plasma human placental lactogen (HPL) from 35 weeks, a rare placental sulphatase deficiency was indicated which was later confirmed by in vitro studies of placental enzyme activities.

scholarly journals Urolithiasis: Update on Metabolic Evaluation of Stone Formers

2005 ◽  
Vol 5 ◽  
pp. 902-914 ◽  
Author(s):  
Sangtae Park ◽  
Margaret S. Pearle
Keyword(s):  
Medical Therapy ◽  
Substantial Reduction ◽  
Screening Tests ◽  
Risk Level ◽  
Initial Screening ◽  
Metabolic Evaluation ◽  
Recurrence Rates ◽  
Stone Recurrence ◽  
Stone Formers ◽  
First Time

Metabolic abnormalities are identified in over 90% of stone formers and the institution of preventative dietary and medical measures has resulted in substantial reduction in stone recurrence rates. We review the contemporary approach to metabolic evaluation of urolithiasis.A careful medical and dietary history, stone analysis, serologic tests, and urinalysis constitute the initial screening regimen in patients who have been diagnosed with stones. Risk stratification of patients, based on the outcome of the initial screening tests, determines the need for and extent of urinary evaluation in individual stone formers. Conservative dietary measures or a simple metabolic evaluation and treatment has been described for first-time or low-risk stone formers, although the number of 24-h urine collections needed is debatable. A more extensive metabolic evaluation is recommended for recurrent or high-risk stone formers or for those in whom empiric treatment or medical therapy based on simplified evaluation is unsuccessful.Regardless of etiology, all stone formers should be counseled on dietary measures for stone prevention. The need for medication is determined by the results of 24-h urine analysis and the risk level of the patient. Cost effectiveness of the metabolic evaluation and treatment is strongly influenced by recurrence rate and efficacy of therapy.Metabolic evaluation and treatment has clearly been shown in randomized trials to reduce stone recurrence rates. Further study will determine the extent of evaluation necessary and the need for selective vs. empiric medical therapy for first-time and recurrent stone formers.

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