Label-Free Analysis of Thrombin or Hg2+Ions by Nucleic Acid-Functionalized Graphene Oxide Matrices Assembled on Field-Effect Transistors

2012 ◽  
Vol 25 (4) ◽  
pp. 851-856 ◽  
Author(s):  
Etery Sharon ◽  
Xiaoqing Liu ◽  
Ronit Freeman ◽  
Omer Yehezkeli ◽  
Itamar Willner
Keyword(s):  
Graphene Oxide ◽  
Nucleic Acid ◽  
Field Effect ◽  
Field Effect Transistors ◽  
Functionalized Graphene ◽  
Label Free ◽  
Functionalized Graphene Oxide

Functionalized graphene oxide mediated nucleic acid delivery

Carbon ◽  
2013 ◽  
Vol 51 ◽  
pp. 224-235 ◽  
Author(s):  
Sushil Kumar Tripathi ◽  
Ritu Goyal ◽  
Kailash Chand Gupta ◽  
Pradeep Kumar
Keyword(s):  
Graphene Oxide ◽  
Nucleic Acid ◽  
Nucleic Acid Delivery ◽  
Functionalized Graphene ◽  
Functionalized Graphene Oxide

scholarly journals New Ultrasensitive Sandwich-Type Immunoassay of Dendritic Tri-Fan Blade-like PdAuCu Nanoparticles/Amine-Functionalized Graphene Oxide for Label-Free Detection of Carcinoembryonic Antigen

Micromachines ◽  
2021 ◽  
Vol 12 (10) ◽  
pp. 1256
Author(s):  
Pingping Xu ◽  
Wenpo Feng ◽  
Mei Wang ◽  
Ling Zhang ◽  
Gaofeng Liang ◽  
...  
Keyword(s):  
Graphene Oxide ◽  
Carcinoembryonic Antigen ◽  
Au Nanoparticle ◽  
Functionalized Graphene ◽  
Label Free ◽  
Functionalized Graphene Oxide ◽  
Amine Functionalized ◽  
Label Free Detection ◽  
Sandwich Type ◽  
Fan Blade

The early detection of tumor markers has an effective role in the treatment of cancer. Here, a new sandwich-type electrochemical immunosensor for early label-free detection of the cancer biomarker carcinoembryonic antigen (CEA) was developed. Dendritic tri-fan blade-like PdAuCu nanoparticles (PdAuCu NPs)/amine functionalized graphene oxide (NH2-GO) were the label of secondary antibodies (Ab2), and Au nanoparticle-decorated polydopamines (Au/PDA) were immobilized on a screen-printed carbon electrode (SPCE) as the substrate materials. Dendritic tri-fan blade-like PdAuCu NPs/NH2-GO was synthesized according to a simple hydrothermal procedure and used to immobilize antibodies (Ab2) with large surfaces areas, increased catalytic properties and good adsorption to amplify the current signals. Subsequently, Ab2/PdAuCu NPs/NH2-GO catalyzed the reduction of H2O2 in the sandwich-type immunoreactions. Under optimal conditions, the immunosensor exhibited a satisfactory response to CEA with a limit detection of 0.07 pg mL−1 and a linear detection range from 0.1 pg mL−1 to 200 ng mL−1. The proposed immunosensor could be suitable enough for a real sample analysis of CEA, and has clinical value in the early diagnosis of cancer.

Polymer Functionalized Graphene Oxide: A Versatile Nanoplatform for Drug/Gene Delivery

2015 ◽  
Vol 19 (18) ◽  
pp. 1828-1837 ◽  
Author(s):  
George V. Theodosopoulos ◽  
Panayiotis Bilalis ◽  
Georgios Sakellariou
Keyword(s):  
Graphene Oxide ◽  
Gene Delivery ◽  
Functionalized Graphene ◽  
Functionalized Graphene Oxide
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