scholarly journals Brain activity modifications following spinal cord stimulation for chronic neuropathic pain: A systematic review

2015 ◽  
Vol 20 (4) ◽  
pp. 499-511 ◽  
Author(s):  
L. D. Bentley ◽  
R. V. Duarte ◽  
P. L. Furlong ◽  
R. L. Ashford ◽  
J. H. Raphael
Keyword(s):  
Systematic Review ◽  
Spinal Cord ◽  
Neuropathic Pain ◽  
Spinal Cord Stimulation ◽  
Brain Activity ◽  
Chronic Neuropathic Pain

First experience with chronic epidural spinal cord stimulation in Khanty-Mansi autonomous okrug — clinical observations

2021 ◽  
Vol LIII (2) ◽  
pp. 94-100
Author(s):  
Olga A. Bondarenko ◽  
Gaspar V. Gavrilov ◽  
Vadim A. Padurets ◽  
Roman V. Kasich
Keyword(s):  
Spinal Cord ◽  
Neuropathic Pain ◽  
Spinal Cord Stimulation ◽  
Pain Syndrome ◽  
Chronic Neuropathic Pain ◽  
Neuropathic Pain Syndrome ◽  
Epidural Stimulation ◽  
Cord Injury ◽  
Epidural Spinal Cord Stimulation ◽  
And Migration

Purpose of the work. The article is devoted to the first experience of epidural stimulation in the Khanty-Mansiysk Autonomous Okrug at the budgetary institution Surgut Clinical Trauma Hospital. Clinical examples are presented for two main indications for the application of this technique (disease of the operated spine, a consequence of spinal cord injury in combination with chronic neuropathic pain syndrome). Research methods. An assessment of the intensity of pain syndrome was given according to a visual analogue scale, the Pain Detect questionnaire; indicators of anxiety, depression on the HADS scale; quality of life according to the Oswestry questionnaire for a follow-up period of 6-12 months in patients with chronic epidural stimulation. Results. A positive assessment of the action during test neurostimulation was 63.3% (38 patients). Of the established permanent systems, a good result was achieved and persisted for 12 months or more in 96% (24 patients). It was necessary to change the stimulation parameters in 13% (3 patients). Revision of permanent systems was performed in 20% (5 patients), due to the progression of the degenerative-dystrophic process of the spine, damage and migration of system elements. Conclusions. Chronic epidural spinal cord stimulation has established itself as a personalized, highly effective, minimally invasive and safe method of treating chronic neuropathic pain syndromes. Multicomponent corrective action is of scientific interest and requires further study.

scholarly journals Spinal Cord Stimulation for Neuropathic Pain: Current Trends and Future Applications

2018 ◽  
Vol 8 (8) ◽  
pp. 138 ◽  
Author(s):  
Ivano Dones ◽  
Vincenzo Levi
Keyword(s):  
Spinal Cord ◽  
Neuropathic Pain ◽  
Spinal Cord Stimulation ◽  
Therapeutic Option ◽  
Neural Pathways ◽  
Chronic Neuropathic Pain ◽  
Pain Medications ◽  
Epidural Spinal Cord Stimulation ◽  
Pain Therapists ◽  
Effective Drugs

The origin and the neural pathways involved in chronic neuropathic pain are still not extensively understood. For this reason, despite the wide variety of pain medications available on the market, neuropathic pain is challenging to treat. The present therapeutic alternative considered as the gold standard for many kinds of chronic neuropathic pain is epidural spinal cord stimulation (SCS). Despite its proved efficacy, the favourable cost-effectiveness when compared to the long-term use of poorly effective drugs and the expanding array of indications and technical improvements, SCS is still worldwide largely neglected by general practitioners, neurologists, neurosurgeons and pain therapists, often bringing to a large delay in considering as a therapeutic option for patients affected by neuropathic chronic pain. The present state of the art of SCS in the treatment of chronic neuropathic pain is here overviewed and speculations on whether to use a trial period or direct implant, to choose between percutaneous leads or paddle electrodes and on the pros and cons of the different patterns of stimulation presently available on the market (tonic stim, high-frequency stim and burst stim) are described.

Effects of spinal cord stimulation on cortical excitability in patients with chronic neuropathic pain: A pilot study

2007 ◽  
Vol 11 (8) ◽  
pp. 863-868 ◽  
Author(s):  
Jürgen R. Schlaier ◽  
Peter Eichhammer ◽  
Berthold Langguth ◽  
Christian Doenitz ◽  
Harald Binder ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Neuropathic Pain ◽  
Pilot Study ◽  
Spinal Cord Stimulation ◽  
Cortical Excitability ◽  
Chronic Neuropathic Pain

scholarly journals A systematic review on descending serotonergic projections and modulation of spinal nociception in chronic neuropathic pain and after spinal cord stimulation

2021 ◽  
Vol 17 ◽  
pp. 174480692110439
Author(s):  
Lonne Heijmans ◽  
Martijn R Mons ◽  
Elbert A Joosten
Keyword(s):  
Systematic Review ◽  
Spinal Cord ◽  
Neuropathic Pain ◽  
Dorsal Horn ◽  
Spinal Dorsal Horn ◽  
Serotonergic System ◽  
Chronic Neuropathic Pain ◽  
Spinal Dorsal ◽  
Important Target ◽  
Serotonergic Modulation

Chronic neuropathic pain is a debilitating ordeal for patients worldwide and pharmacological treatment efficacy is still limited. As many pharmacological interventions for neuropathic pain often fail, insights into the underlying mechanism and role of identified receptors is of utmost importance. An important target for improving treatment of neuropathic pain is the descending serotonergic system as these projections modulate nociceptive signaling in the dorsal horn. Also with use of last resort treatments like spinal cord stimulation (SCS), the descending serotonergic projections are known to be involved in the pain relieving effect. This systematic review summarizes the involvement of the serotonergic system on nociceptive modulation in the healthy adult rodent and the chronic neuropathic rodent and summarizes all available literature on the serotonergic system in the SCS-treated neuropathic rodent. Medline, Embase and Pubmed databases were used in the search for articles. Descending serotonergic modulation of nociceptive signaling in spinal dorsal horn in normal adult rat is mainly inhibitory and mediated by 5-HT1a, 5-HT1b, 5-HT2c, 5-HT3 and 5-HT4 receptors. Upon injury and in the neuropathic rat, this descending serotonergic modulation becomes facilitatory via activation of the 5-HT2a, 5-HT2b and 5-HT3 receptors. Analgesia due to neuromodulatory intervention like SCS restores the inhibitory function of the descending serotonergic system and involves 5-HT2, 5-HT3 and 5-HT4 receptors. The results of this systematic review provide insights and suggestions for further pharmacological and or neuromodulatory treatment of neuropathic pain based on targeting selected serotonergic receptors related to descending modulation of nociceptive signaling in spinal dorsal horn. With the novel developed SCS paradigms, the descending serotonergic system will be an important target for mechanism-based stimulation induced analgesia.

scholarly journals Spinal cord stimulation in the management of neuropathic pain in cancer patients: case report

2020 ◽  
Vol 49 (2) ◽  
Author(s):  
Valeria Quintero-Carreño ◽  
Bilena Margarita-Molina ◽  
Carlos Hernán Rodríguez-Martínez
Keyword(s):  
Spinal Cord ◽  
Neuropathic Pain ◽  
Cancer Patients ◽  
Spinal Cord Stimulation ◽  
Femoral Nerve ◽  
Chronic Neuropathic Pain ◽  
Nerve Blocks ◽  
Curative Intent ◽  
Number Of Patients ◽  
Improved Function

Introduction: Neuropathic pain is present in up to 40 % of all cancer patients. A considerable number of patients fail to achieve enough pain relief with conventional treatment, which is why therapeutic alternatives such as spinal cord stimulation should be considered. Case description and results: This is the case of a female patient with chronic neuropathic pain secondary to a partial femoral nerve injury sustained during resection and lymph node dissection surgery with curative intent for a large stage II cell squamous cell carcinoma T2N0M0, localized in the right popliteal fossa. The patient presented with difficult to manage chronic neuropathic pain, despite receiving multiple oral analgesics and nerve blocks. A medullary neurostimulator was implanted that relieved the patient’s pain intensity in up to 80%, in addition to improved function and quality of life. Conclusions: spinal cord stimulation is considered an effective neuromodulatory intervention which has shown satisfactory results in the treatment of various types of refractory chronic pain in cancer patients, including neuropathic pain.

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