scholarly journals Sick leave due to back pain, common mental disorders and disability pension: Common genetic liability

2020 ◽  
Vol 24 (10) ◽  
pp. 1892-1901
Author(s):  
Lisa Mather ◽  
Sanna Kärkkäinen ◽  
Jurgita Narusyte ◽  
Annina Ropponen ◽  
Ellenor Mittendorfer‐Rutz ◽  
...  
Keyword(s):  
Back Pain ◽  
Mental Disorders ◽  
Sick Leave ◽  
Disability Pension ◽  
Common Mental Disorders ◽  
Genetic Liability

Synergistic effect between back pain and common mental disorders and the risk of future disability pension: a nationwide study from Sweden

2015 ◽  
Vol 46 (2) ◽  
pp. 425-436 ◽  
Author(s):  
T. E. Dorner ◽  
K. Alexanderson ◽  
P. Svedberg ◽  
P. Tinghög ◽  
A. Ropponen ◽  
...  
Keyword(s):  
Back Pain ◽  
Mental Disorders ◽  
Synergistic Effect ◽  
Sickness Absence ◽  
Outpatient Care ◽  
Disability Pension ◽  
Common Mental Disorders ◽  
Hazard Ratios ◽  
Co Morbidity ◽  
Individual Condition

BackgroundThe aim of this study was to analyse a possible synergistic effect between back pain and common mental disorders (CMDs) in relation to future disability pension (DP).MethodAll 4 823 069 individuals aged 16–64 years, living in Sweden in December 2004, not pensioned in 2005 and without ongoing sickness absence at the turn of 2004/2005 formed the cohort of this register-based study. Hazard ratios (HRs) and 95% confidence intervals (CIs) for DP (2006–2010) were estimated. Exposure variables were back pain (M54) (sickness absence or inpatient or specialized outpatient care in 2005) and CMD (F40-F48) [sickness absence or inpatient or specialized outpatient care or antidepressants (N06a) in 2005].ResultsHRs for DP were 4.03 (95% CI 3.87–4.21) and 3.86 (95% CI 3.68–4.04) in women and men with back pain. HRs for DP in women and men with CMD were 4.98 (95% CI 4.88–5.08) and 6.05 (95% CI 5.90–6.21). In women and men with both conditions, HRs for DP were 15.62 (95% CI 14.40–16.94) and 19.84 (95% CI 17.94–21.94). In women, synergy index, relative excess risk due to interaction, and attributable proportion were 1.24 (95% CI 1.13–1.36), 0.18 (95% CI 0.11–0.25), and 2.08 (95% CI 1.09–3.06). The corresponding figures for men were 1.45 (95% CI 1.29–1.62), 0.29 (95% CI 0.22–0.36), and 4.21 (95% CI 2.71–5.70).ConclusionsCo-morbidity of back pain and CMD is associated with a higher risk of DP than either individual condition, when added up, which has possible clinical implications to prevent further disability and exclusion from the labour market.

scholarly journals Suicide attempt following sickness absence and disability pension due to common mental disorders: a prospective Swedish twin study

2019 ◽  
Vol 55 (8) ◽  
pp. 1053-1060 ◽  
Author(s):  
M. Wang ◽  
L. Mather ◽  
P. Svedberg ◽  
E. Mittendorfer-Rutz
Keyword(s):  
Mental Disorders ◽  
Suicide Attempt ◽  
Sickness Absence ◽  
Disability Pension ◽  
Depressive Disorders ◽  
Proportional Hazards ◽  
Common Mental Disorders ◽  
Cox Proportional Hazards ◽  
Shared Environment ◽  
Familial Factors

Abstract Purpose The aim of this study was to investigate if sickness absence and disability pension (SA/DP) in general and due to specific common mental disorders (CMDs) are associated with subsequent suicide attempt among women and men by taking familial factors (genetics and shared environment) into consideration. Methods This register-based cohort study includes 4871 twin pairs 18–65 years of age discordant for SA/DP due to CMDs 2005–2010. Twins were followed up for suicide attempt from inpatient and specialised outpatient care until December 2012. Conditional Cox proportional hazards regression models, adjusting for familial factors, were used to calculate hazard ratios (HR) with 95% confidence intervals (CI). Results SA/DP due to CMDs was associated with a higher risk of suicide attempt (HR 3.14, CI 2.51–3.93). The risk of suicide attempt was five times higher among men and three times higher among women, compared to the SA/DP unaffected co-twins. In the diagnosis-specific analysis, SA/DP due to anxiety disorders resulted in the highest HR (4.09, CI 2.37–7.06) for suicide attempt, followed by depressive disorders (HR 3.70, CI 2.66–5.14) and stress-related disorders (HR 1.96, CI 1.35–2.84). The stratified analysis on zygosity indicates that there seems to be a genetic influence on the associations between SA/DP due to CMDs and suicide attempt, particularly among women and among those with SA/DP due to depressive disorders. Conclusions SA/DP due to CMDs was a risk factor for suicide attempt among women and men. Genetic factors might explain part of the associations for women and for those with SA/DP due to depressive disorders.

scholarly journals Trajectories of antidepressant use and characteristics associated with trajectory groups among young refugees and their Swedish-born peers with diagnosed common mental disorders—findings from the REMAIN study

2021 ◽  
Author(s):  
S. Rahman ◽  
S. Filatova ◽  
L. Chen ◽  
E. Björkenstam ◽  
H. Taipale ◽  
...  
Keyword(s):  
Mental Disorders ◽  
Disability Pension ◽  
Common Mental Disorders ◽  
Multinomial Logistic Regression ◽  
Common Mental Disorder ◽  
Influential Factors ◽  
Transcultural Psychiatry ◽  
Refugee Youth ◽  
Study Population ◽  
Antidepressant Use

Abstract Purpose This study aimed to (1) identify the trajectories of prescribed antidepressants in refugee youth and matched Swedish-born peers diagnosed with common mental disorder (CMD) and (2) characterize the trajectories according to sociodemographic and medical factors. Methods The study population comprised 2,198 refugees and 12,199 Swedish-born individuals with both Swedish-born parents, aged 16–25 years in 2011, residing in Sweden and treated in specialised healthcare for CMD 2009–11. Group-based trajectory modelling was used to identify different trajectory groups of antidepressant use-based on annual defined daily dosages (DDDs). Multinomial logistic regression was applied to investigate the association of sociodemographic and medical characteristics with the identified trajectories. Nagelkerke pseudo-R2 values were estimated to evaluate the strength of these associations. Results Four trajectory groups of antidepressant use among young refugees were identified with following proportions and DDD levels in 2011: ‘low constant’ (88%, < 100), ‘low increasing’ (2%, ≈710), ‘medium decreasing’ (8%, ≈170) and ‘high increasing’ (2%, ≈860). Similar trajectories, however, with different proportions were identified in Swedish-born: 67%, 7%, 21% and 5%, respectively. The most influential factors discriminating the trajectory groups among refugees were ‘duration of stay in Sweden’ (R2 = 0.013), comorbid ‘other mental disorders’ (R2 = 0.009) and ‘disability pension’ (R2 = 0.007), while ‘disability pension’ (R2 = 0.017), comorbid ‘other mental disorders’ (R2 = 0.008) and ‘educational level’ (R2 = 0.008) were the most important determinants discriminating trajectory groups among Swedish-born youth. Conclusion The lower use of antidepressants in refugees with CMDs compared to their Swedish-born counterparts warrants health literacy programs for refugees and training in transcultural psychiatry for healthcare professionals.

A Population-Based Cohort Study of the Effect of Common Mental Disorders on Disability Pension Awards

2006 ◽  
Vol 163 (8) ◽  
pp. 1412-1418 ◽  
Author(s):  
Arnstein Mykletun ◽  
Simon Overland ◽  
Alv A. Dahl ◽  
Steinar Krokstad ◽  
Ottar Bjerkeset ◽  
...  
Keyword(s):  
Cohort Study ◽  
Mental Disorders ◽  
Disability Pension ◽  
Common Mental Disorders ◽  
Population Based

The Covariation Between Burnout and Sick Leave Due to Mental Disorders Is Explained by a Shared Genetic Liability: A Prospective Swedish Twin Study With a Five-Year Follow-up

2014 ◽  
Vol 17 (6) ◽  
pp. 535-544 ◽  
Author(s):  
Lisa Mather ◽  
Gunnar Bergström ◽  
Victoria Blom ◽  
Pia Svedberg
Keyword(s):  
Logistic Regression ◽  
Mental Disorders ◽  
Environmental Factors ◽  
Sick Leave ◽  
Social Insurance ◽  
Conditional Logistic Regression ◽  
Phenotypic Correlation ◽  
Genetic Liability ◽  
Familial Factors ◽  
Shared Genetic

Background: This study aims to assess whether the associations between burnout and sick leave due to stress-related mental disorders, other mental disorders, and somatic conditions are influenced by familial (genetic and shared environmental) factors.Methods: In this prospective cohort study, 23,611 Swedish twins born between 1959 and 1985, who answered a web-based questionnaire, including the Pines Burnout Measure 2004–2006, were included. Registry data on sick leave spells from the response date until December 31, 2010 were obtained from the Swedish Social Insurance Agency. Logistic regression analysis was performed to assess odds ratios with 95% confidence intervals for the association between burnout and sick leave for the whole sample, while conditional logistic regression of the same-sex discordant twin pairs was used to estimate the association between burnout and sick leave, adjusting for familial confounding. The Bivariate Cholesky models were used to assess whether the covariation between burnout and sick leave was explained by common genetic and/or shared environmental factors.Results: Burnout was a risk factor for sick leave due to stress-related and other mental disorders, and these associations were explained by familial factors. The phenotypic correlation between burnout and sick leave due to somatic conditions was 0.07 and the association was not influenced by familial factors. The phenotypic correlations between burnout and sick leave due to stress-related (0.26) and other mental disorders (0.30) were completely explained by common genetic factors.Conclusions: The association between burnout and sick leave due to stress-related and other mental disorders seems to be a reflection of a shared genetic liability.

O07-4 Work functioning after sick leave due to common mental disorders: the effect of multimorbidity

2016 ◽  
Author(s):  
Monica Ubalde-Lopez ◽  
Iris Arends ◽  
Josue Almansa ◽  
George Delclos ◽  
David Gimeno ◽  
...  
Keyword(s):  
Mental Disorders ◽  
Sick Leave ◽  
Common Mental Disorders ◽  
Work Functioning

scholarly journals Early and Late Return to Work After Sick Leave: Predictors in a Cohort of Sick-Listed Individuals with Common Mental Disorders

2015 ◽  
Vol 25 (3) ◽  
pp. 627-637 ◽  
Author(s):  
Kerstin Ekberg ◽  
Charlotte Wåhlin ◽  
Jan Persson ◽  
Lars Bernfort ◽  
Birgitta Öberg
Keyword(s):  
Mental Disorders ◽  
Sick Leave ◽  
Return To Work ◽  
Common Mental Disorders
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