GABAergic modulation of secondary hyperalgesia: A randomized controlled 4‐way crossover trial with the α2‐subunit preferring GABA positive allosteric modulator,
            N
            ‐desmethyl‐clobazam in healthy volunteers

Alain Matthey; Youssef Daali; François Curtin; Antoine Poncet; Jules Desmeules; Marie Besson

doi:10.1002/ejp.1554

GABAergic modulation of secondary hyperalgesia: A randomized controlled 4‐way crossover trial with the α2‐subunit preferring GABA positive allosteric modulator, N ‐desmethyl‐clobazam in healthy volunteers

European Journal of Pain ◽

10.1002/ejp.1554 ◽

2020 ◽

Vol 24 (6) ◽

pp. 1094-1106

Author(s):

Alain Matthey ◽

Youssef Daali ◽

François Curtin ◽

Antoine Poncet ◽

Jules Desmeules ◽

...

Keyword(s):

Healthy Volunteers ◽

Crossover Trial ◽

Allosteric Modulator ◽

Secondary Hyperalgesia ◽

Positive Allosteric Modulator ◽

Randomized Controlled ◽

Gabaergic Modulation

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Acute effects of light and dark roasted coffee on glucose tolerance: a randomized, controlled crossover trial in healthy volunteers

European Journal of Nutrition ◽

10.1007/s00394-015-1032-9 ◽

2015 ◽

Vol 55 (7) ◽

pp. 2221-2230 ◽

Cited By ~ 15

Author(s):

Elin Rakvaag ◽

Lars Ove Dragsted

Keyword(s):

Glucose Tolerance ◽

Healthy Volunteers ◽

Crossover Trial ◽

Acute Effects ◽

Roasted Coffee ◽

Randomized Controlled

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Effect of valdecoxib pretreatment on pain and secondary hyperalgesia: a randomized controlled trial in healthy volunteers [ISRCTN05282752, NCT00260325]

BMC Anesthesiology ◽

10.1186/1471-2253-6-3 ◽

2006 ◽

Vol 6 (1) ◽

Cited By ~ 6

Author(s):

David Burns ◽

Lindsay Hill ◽

Michael Essandoh ◽

Tomasz M Jarzembowski ◽

H Gregg Schuler ◽

...

Keyword(s):

Randomized Controlled Trial ◽

Healthy Volunteers ◽

Controlled Trial ◽

Secondary Hyperalgesia ◽

Randomized Controlled

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The dopamine D1 receptor positive allosteric modulator mevidalen (LY3154207) enhances wakefulness in the humanized D1 mouse and in sleep deprived healthy volunteers.

Journal of Pharmacology and Experimental Therapeutics ◽

10.1124/jpet.121.000719 ◽

2021 ◽

pp. JPET-AR-2021-000719

Author(s):

Andrew P McCarthy ◽

Kjell A Svensson ◽

Elaine Shanks ◽

Claire Brittain ◽

Brian J Eastwood ◽

...

Keyword(s):

Healthy Volunteers ◽

Dopamine D1 Receptor ◽

D1 Receptor ◽

Allosteric Modulator ◽

Positive Allosteric Modulator

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Safety, Tolerability, and Pharmacokinetics of Multiple Repeated Oral Doses of the α2/3/5‐Subtype Selective GABA A ‐Positive Allosteric Modulator PF‐06372865 in Healthy Volunteers

Clinical Pharmacology in Drug Development ◽

10.1002/cpdd.912 ◽

2021 ◽

Author(s):

Rachel Gurrell ◽

Mark Whitlock ◽

Hua Wei ◽

Zhongzhou Shen ◽

Adam Ogden

Keyword(s):

Healthy Volunteers ◽

Allosteric Modulator ◽

Positive Allosteric Modulator ◽

Gaba A ◽

Subtype Selective ◽

Oral Doses

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Correction: Structural modeling and role of HAX-1 as a positive allosteric modulator of human serine protease HtrA2

Biochemical Journal ◽

10.1042/bcj-2019-0569_cor ◽

2020 ◽

Vol 477 (2) ◽

pp. 459-459

Author(s):

Lalith K. Chaganti ◽

Shubhankar Dutta ◽

Raja Reddy Kuppili ◽

Mriganka Mandal ◽

Kakoli Bose

Keyword(s):

Serine Protease ◽

Structural Modeling ◽

Allosteric Modulator ◽

Positive Allosteric Modulator

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The effect of mGluR2 3 agonist, LY379268, and a mGluR4 positive allosteric modulator, VU0155041, on conditioned taste aversion

10.32469/10355/40222 ◽

2013 ◽

Author(s):

Diana Klakotskaia

Keyword(s):

Taste Aversion ◽

Conditioned Taste Aversion ◽

Allosteric Modulator ◽

Positive Allosteric Modulator

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Faculty Opinions recommendation of The learning curve associated with the epidural technique using the Episure™ AutoDetect™ versus conventional glass syringe: an open-label, randomized, controlled, crossover trial of experienced anesthesiologists in obstetric patients.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.717969509.793479303 ◽

2013 ◽

Author(s):

Michael Paech

Keyword(s):

Learning Curve ◽

Crossover Trial ◽

Open Label ◽

Randomized Controlled ◽

Glass Syringe

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Faculty of 1000 evaluation for The learning curve associated with the epidural technique using the Episure™ AutoDetect™ versus conventional glass syringe: an open-label, randomized, controlled, crossover trial of experienced anesthesiologists in obstetric patients.

F1000 - Post-publication peer review of the biomedical literature ◽

10.3410/f.717969509.793470379 ◽

2013 ◽

Author(s):

Timothy Short

Keyword(s):

Learning Curve ◽

Crossover Trial ◽

Open Label ◽

Randomized Controlled ◽

Glass Syringe

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Faculty Opinions recommendation of Acute effects of aerosolized iloprost in COPD related pulmonary hypertension - a randomized controlled crossover trial.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.717976297.793472183 ◽

2013 ◽

Author(s):

Alice Turner

Keyword(s):

Pulmonary Hypertension ◽

Crossover Trial ◽

Acute Effects ◽

Randomized Controlled

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Faculty of 1000 evaluation for Acute Effects of Aerosolized Iloprost in COPD Related Pulmonary Hypertension - A Randomized Controlled Crossover Trial.

F1000 - Post-publication peer review of the biomedical literature ◽

10.3410/f.717976297.793471443 ◽

2013 ◽

Author(s):

Shawn Aaron

Keyword(s):

Pulmonary Hypertension ◽

Crossover Trial ◽

Acute Effects ◽

Randomized Controlled

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