scholarly journals The new micropatterned interdigitated electrode for selective assessment of the nociceptive system

2020 ◽  
Vol 24 (5) ◽  
pp. 956-966
Author(s):  
Giulia Di Stefano ◽  
Andrea Di Lionardo ◽  
Silvia La Cesa ◽  
Giuseppe Di Pietro ◽  
Alessandra Fasolino ◽  
...  
Keyword(s):  
Interdigitated Electrode ◽  
Nociceptive System

scholarly journals Observation of Nociceptive Processing: Effect of Intra-Epidermal Electric Stimulus Properties on Detection Probability and Evoked Potentials

2021 ◽  
Vol 34 (2) ◽  
pp. 139-153
Author(s):  
Boudewijn van den Berg ◽  
Jan R. Buitenweg
Keyword(s):  
Evoked Potentials ◽  
Detection Probability ◽  
Pulse Interval ◽  
System Behavior ◽  
Stimulus Properties ◽  
Nociceptive System ◽  
Nociceptive Stimulus ◽  
Peripheral Nerve Fiber ◽  
Nociceptive Processing ◽  
Mixed Regression

AbstractMonitoring nociceptive processing is a current challenge due to a lack of objective measures. Recently, we developed a method for simultaneous tracking of psychophysical detection probability and brain evoked potentials in response to intra-epidermal stimulation. An exploratory investigation showed that we could quantify nociceptive system behavior by estimating the effect of stimulus properties on the evoked potential (EP). The goal in this work was to accurately measure nociceptive system behavior using this method in a large group of healthy subjects to identify the locations and latencies of EP components and the effect of single- and double-pulse stimuli with an inter-pulse interval of 10 or 40 ms on these EP components and detection probability. First, we observed the effect of filter settings and channel selection on the EP. Subsequently, we compared statistical models to assess correlation of EP and detection probability with stimulus properties, and quantified the effect of stimulus properties on both outcome measures through linear mixed regression. We observed lateral and central EP components in response to intra-epidermal stimulation. Detection probability and central EP components were positively correlated to the amplitude of each pulse, regardless of the inter-pulse interval, and negatively correlated to the trial number. Both central and lateral EP components also showed strong correlation with detection. These results show that both the observed EP and the detection probability reflect the various steps of processing of a nociceptive stimulus, including peripheral nerve fiber recruitment, central synaptic summation, and habituation to a repeated stimulus.

Capacitive aptasensor based on interdigitated electrode for breast cancer detection in undiluted human serum

2018 ◽  
Vol 102 ◽  
pp. 106-112 ◽  
Author(s):  
Sunil K. Arya ◽  
Pavel Zhurauski ◽  
Pawan Jolly ◽  
Marina R. Batistuti ◽  
Marcelo Mulato ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Human Serum ◽  
Cancer Detection ◽  
Breast Cancer Detection ◽  
Interdigitated Electrode

scholarly journals Gold-nanourchin complexed silicon dioxide-probe on gap-fingered interdigitated electrode surface for Parkinson’s Disease determination by current–volt measurement

2021 ◽  
Vol 11 ◽  
pp. 184798042098735
Author(s):  
Xiaohong Li ◽  
Wei Shi ◽  
Wenyan Zhang ◽  
Weiyao Chen ◽  
Dan Cao ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Silicon Dioxide ◽  
Limit Of Detection ◽  
Detection System ◽  
Interdigitated Electrode ◽  
Limit Of Quantification ◽  
Neurofilament Light Chain ◽  
Neurofilament Light ◽  
Detection Range

Parkinson’s disease (PD) is a nervous disorder, affects physical movement, and leads to difficulty in balancing, walking, and coordination. A novel sensor is mandatory to determine PD and monitor the progress of the treatment. Neurofilament light chain (NfL) has been recognized as a good biomarker for PD and also helps to distinguish between PD and atypical PD syndromes. Immunosensor was generated by current–volt measurement on gap-fingered interdigitated electrode with silicon dioxide surface to determine NfL level. To enhance the detection, anti-NfL antibody was complexed with gold-nanourchin and immobilized on the sensing electrode. The current–volt response was gradually increased at the linear detection range from 100 fM to 1 nM. Limit of detection and sensitivity were 100 fM with the signal-to-noise ratio at n = 3 on a linear curve ( y = 0.081 x + 1.593; R 2 = 0.9983). Limit of quantification falls at 1 pM and high performance of the sensor was demonstrated by discriminating against other neurogenerative disease markers, in addition, it was reproducible even in serum-spiked samples. This method of detection system aids to measure the level of NfL and leads to determine the condition with PD.

scholarly journals H2S-Sensing Studies Using Interdigitated Electrode with Spin-Coated Carbon Aerogel-Polyaniline Composites

Polymers ◽  
2021 ◽  
Vol 13 (9) ◽  
pp. 1457
Author(s):  
Aamna Bibi ◽  
Yuola Rose M. Rubio ◽  
Karen S. Santiago ◽  
His-Wei Jia ◽  
Mahmoud M. M. Ahmed ◽  
...  
Keyword(s):  
Gas Sensing ◽  
Carbon Aerogel ◽  
Average Response Time ◽  
Interdigitated Electrode ◽  
Gas Sensing Properties ◽  
Increased Sensitivity ◽  
Good Repeatability ◽  
Polyaniline Composites ◽  
Coated Carbon ◽  
Better Than

In this paper, carbon aerogel (CA)-polyaniline (PANI) composites were prepared and first applied in the study of H2S gas sensing. Here, 1 and 3 wt% of as-obtained CA powder were blended with PANI to produce composites, which are denoted by PANI-CA-1 and PANI-CA-3, respectively. For the H2S gas-sensing studies, the interdigitated electrode (IDE) was spin-coated by performing PANI and PANI-CA composite dispersion. The H2S gas-sensing properties were studied in terms of the sensor’s sensitivity, selectivity and repeatability. IDE coated with PANI-CA composites, as compared with pristine PANI, achieved higher sensor sensitivity, higher selectivity and good repeatability. Moreover, composites that contain higher loading of CA (e.g., 3 wt%) perform better than composites with lower loading of CA. At 1 ppm, PANI-CA-3 displayed increased sensitivity of 452% at relative humidity of 60% with a fast average response time of 1 s compared to PANI.

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