Construction of benzo‐fused heterocycles by epoxide – heteronucleophile cyclization: applications in the synthesis of natural products and designed molecules
p-Tosylmethyl isocyanide (TosMIC), an α-acidic isocyanide has emerged as a privileged reagent to access biologically relevant fused heterocycles and some natural products like (−)-ushikulide A, variolin B, porphobilinogen and mansouramycin B.
A pyrone remodeling strategy to access diverse heterocycles: application to the synthesis of fascaplysin natural products