Supported synthesis of adenosine nucleotides and derivatives on a benzene‐centred tripodal soluble support

2021 ◽  
Author(s):  
Lucie Appy ◽  
Suzanne Peyrottes ◽  
Béatrice Roy
Keyword(s):  
Adenosine Nucleotides

DMACM-Caged Adenosine Nucleotides: Ultrafast Phototriggers for ATP, ADP, and AMP Activated by Long-Wavelength Irradiation

ChemBioChem ◽  
2003 ◽  
Vol 4 (2-3) ◽  
pp. 162-170 ◽  
Author(s):  
Daniel Geißler ◽  
Wolfgang Kresse ◽  
Burkhard Wiesner ◽  
Jürgen Bendig ◽  
Helmut Kettenmann ◽  
...  
Keyword(s):  
Long Wavelength ◽  
Adenosine Nucleotides

Determination of adenosine nucleotides

1968 ◽  
Vol 22 (2) ◽  
pp. 355-357 ◽  
Author(s):  
Chien-Ho Chiu-Lin
Keyword(s):  
Adenosine Nucleotides

Adenosine nucleotides in bile

1996 ◽  
Vol 270 (2) ◽  
pp. G246-G252 ◽  
Author(s):  
R. S. Chari ◽  
S. M. Schutz ◽  
J. E. Haebig ◽  
G. H. Shimokura ◽  
P. B. Cotton ◽  
...  
Keyword(s):  
Purinergic Receptors ◽  
Purinergic Receptor ◽  
Receptor Activation ◽  
Hepatoma Cells ◽  
Human Bile ◽  
Nucleotide Release ◽  
Cholangiocarcinoma Cell ◽  
Adenosine Nucleotides ◽  
Vitro Model

Activation of purinergic receptors by ATP stimulates Cl- efflux in biliary epithelial cells. To determine whether purinergic agonists are present under physiological conditions, we have assayed mammalian bile for nucleotides and assessed whether hepatoma and cholangiocarcinoma cell lines are capable of nucleotide release. Bile samples were collected from human, rat, and pig donors and assayed for nucleotide concentrations by luminometry. ATP, ADP, and AMP were present in bile from each species, and the average total nucleotide concentration in human bile was 5.21 +/- 0.91 microM (n = 16). In an in vitro model of HTC rat hepatoma cells or Mz-ChA-1 cholangiocarcinoma cells on a superfused column, nucleotides were present in the effluent from each cell type. Addition of alpha, beta-methyleneadenosine 5'-diphosphate (50 microM) to inhibit 5'-nucleotidase activity increased AMP concentrations two- to threefold. Exposure to forskolin (100 microM) or ionomycin (2 microM) stimulated nucleotide release from cholangiocarcinoma but not hepatoma cells. These studies indicate that adenosine nucleotides are present in bile in concentrations sufficient to activate purinergic receptors. Purinergic receptor activation by local nucleotide release might constitute an autocrine and/or paracrine mechanism for modulation of biliary secretion.

Release of ADP from Erythrocytes Under High Shear Stresses in Tube Flow

1979 ◽  
Author(s):  
H. Schmid-Schönbein ◽  
I. Rohling-Winkel ◽  
P. Blasberg ◽  
E. Jüngling ◽  
A. Wehmeyer ◽  
...  
Keyword(s):  
Fluid Layer ◽  
Shape Change ◽  
Total Concentration ◽  
Shear Stresses ◽  
Tube Flow ◽  
High Shear ◽  
Hemoglobin Content ◽  
Before And After ◽  
Adp Release ◽  
Adenosine Nucleotides

ADP stemning from red blood has been shown to “activate platelets” producing shape change, as well as aggregation and release. However, the mode of release of ADP from intact RBC has never been established. Contrary to popular misconceptions, high shear stresses (τ) prevail during natural hemostatic plug formationin arteries and arterioles. Therefore, we tested ADP-release from RBC subjected for 5-100 msec in tube flow (τ-0-200N/m2) during passage through a hollow fiber (0 400 μm, L = 20 cm) with semipermeable walls (AMICON R). Samples from the fluid layer near the wall were ultrafiltered through it and became accessible for chemical analysis. Concentrations of K+, adenosine nucleotides (HPLC), and Hb (In the supernatant) before and after shear exposure were measured. At T > 50 N/m2T K+, adenosine nue Ieotides, and hemoglobin concentrations rose in the supernatant. Only K+ was higher in the u1 trafiltrate than in the latter, whereas total concentration of adenosine nucleotides were not different and hemoglobin did not permeate. There was no difference between the relative molar concentration of total adenosine nucleotides of hemoglobin, i.e. the nucleotides and hemoglobin content of 10-4 and 10-3 of all RBC were liberated. In the ultrafiltrate (ADP) > 2 χ 10-7 M/L, sufficient to activate platelets in the presence of Ca++.

Thermodynamic analysis of interactions of the Hsp90 with adenosine nucleotides: A comparative perspective

2019 ◽  
Vol 130 ◽  
pp. 125-138 ◽  
Author(s):  
Karine Minari ◽  
Érika Chang de Azevedo ◽  
Vanessa Thomaz Rodrigues Kiraly ◽  
Fernanda Aparecida Heleno Batista ◽  
Fábio Rogério de Moraes ◽  
...  
Keyword(s):  
Thermodynamic Analysis ◽  
Comparative Perspective ◽  
Adenosine Nucleotides

scholarly journals Adenosine Nucleotides Acting at the Human P2Y1Receptor Stimulate Mitogen-activated Protein Kinases and Induce Apoptosis

2001 ◽  
Vol 276 (19) ◽  
pp. 16379-16390 ◽  
Author(s):  
Lynda A. Sellers ◽  
Joseph Simon ◽  
Tina S. Lundahl ◽  
Diane J. Cousens ◽  
Patrick P. A. Humphrey ◽  
...  
Keyword(s):  
Protein Kinases ◽  
Mitogen Activated Protein Kinases ◽  
Mitogen Activated Protein ◽  
Adenosine Nucleotides

Erythrocyte Concentration of Glycolytic Phosphorylated Intermediates and Adenosine Nucleotides in Subjects with Diabetes Mellitus

1982 ◽  
Vol 14 (05) ◽  
pp. 233-236 ◽  
Author(s):  
L. Scionti ◽  
A. Puxeddu ◽  
G. Calabrese ◽  
C. Gatteschi ◽  
M. De Angelis ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Erythrocyte Concentration ◽  
Adenosine Nucleotides
Sign in / Sign up

Export Citation Format

Share Document