A 2000 to 2020 Practitioner’s Guide to Chiral Amine Based Enantioselective Aldol Reactions:Common Ketone Substrates,Best Methods,in Water Reaction Environments,and Defining Nuances

2021 ◽  
Author(s):  
Thomas Christopher Nugent ◽  
Alice E. de Vos ◽  
Ishtiaq Hussian ◽  
Hussein Ali El Damrany Hussein ◽  
Falguni Goswami
Keyword(s):  
Chiral Amine

Continuous production of a chiral amine in a packed bed reactor with co-immobilized amine dehydrogenase and formate dehydrogenase

2021 ◽  
Vol 407 ◽  
pp. 127065
Author(s):  
Robert D. Franklin ◽  
Joshua A. Whitley ◽  
Adam A. Caparco ◽  
Bettina R. Bommarius ◽  
Julie A. Champion ◽  
...  
Keyword(s):  
Formate Dehydrogenase ◽  
Continuous Production ◽  
Packed Bed ◽  
Packed Bed Reactor ◽  
Chiral Amine ◽  
Amine Dehydrogenase

scholarly journals Continuous Flow Chiral Amine Racemization Applied to Continuously Recirculating Dynamic Diastereomeric Crystallizations

2021 ◽  
Vol 86 (3) ◽  
pp. 2458-2473
Author(s):  
Maria H. T. Kwan ◽  
Jessica Breen ◽  
Martin Bowden ◽  
Louis Conway ◽  
Ben Crossley ◽  
...  
Keyword(s):  
Continuous Flow ◽  
Chiral Amine

Engineering the large pocket of an (S)-selective transaminase for asymmetric synthesis of (S)-1-amino-1-phenylpropane

2021 ◽  
Author(s):  
Youyu Xie ◽  
Feng Xu ◽  
Lin Yang ◽  
He Liu ◽  
Xiangyang Xu ◽  
...  
Keyword(s):  
Asymmetric Synthesis ◽  
Environmentally Benign ◽  
Chiral Amine ◽  
Synthesis Route

Amine transaminases offer an environmentally benign chiral amine asymmetric synthesis route.

Short syntheses of 1-substituted dibenzothiophene derivatives

2021 ◽  
Vol 19 (9) ◽  
pp. 2000-2007
Author(s):  
Erin N. Welsh ◽  
Katherine N. Robertson ◽  
Alexander W. H. Speed
Keyword(s):  
Cross Coupling ◽  
One Pot ◽  
Chiral Amine ◽  
Rapid Access

A one-pot double benzyne cascade allows rapid access to 1-substituted dibenzothiophene derivatives, including cross-coupling partners and a chiral amine.

ChemInform Abstract: Chiral Amine—Polyoxometalate Hybrids as Highly Efficient and Recoverable Asymmetric Enamine Catalysts.

ChemInform ◽  
2008 ◽  
Vol 39 (4) ◽  
Author(s):  
Sanzhong Luo ◽  
Jiuyuan Li ◽  
Hui Xu ◽  
Long Zhang ◽  
Jin-Pei Cheng
Keyword(s):  
Chiral Amine ◽  
Highly Efficient

scholarly journals Circular dichroism of multi-component assemblies for chiral amine recognition and rapid ee determination

2012 ◽  
Vol 3 (1) ◽  
pp. 156-161 ◽  
Author(s):  
Pedro Metola ◽  
Eric V. Anslyn ◽  
Tony D. James ◽  
Steven D. Bull
Keyword(s):  
Circular Dichroism ◽  
Chiral Amine ◽  
Circular Dichroïsm

scholarly journals Dynamism and Cooperativity Essential for Efficient Catalysis in Aspergillus Niger Monoamine Oxidase

2019 ◽  
Author(s):  
Christian Curado-Carballada ◽  
Ferran Feixas ◽  
Sílvia Osuna
Keyword(s):  
Aspergillus Niger ◽  
Monoamine Oxidase ◽  
Active Site ◽  
Conformational Dynamics ◽  
Catalytic Efficiency ◽  
Building Blocks ◽  
Chiral Amine ◽  
Evolutionary Pathway ◽  
Accelerated Molecular Dynamics ◽  
Open States

<p><b> </b><i>Aspergillus niger </i>Monoamine Oxidase (MAO-N) is a homodimeric enzyme responsible for the oxidation of amines into the corresponding imine. Laboratory evolved variants of MAO-N in combination with a non-selective chemical reductant represents a powerful strategy for the deracemisation of chiral amine mixtures and, thus, is of interest for obtaining chiral amine building blocks. MAO-N presents a rich conformational dynamics with a flexible ß-hairpin region that can adopt closed, partially closed and open states. Despite the ß-hairpin conformational dynamics is altered along the laboratory evolutionary pathway of MAO-N, the connection between the ß-hairpin conformational dynamics and active site catalysis still remains unclear. In this work, we use accelerated molecular dynamics to elucidate the potential interplay between the ß-hairpin conformational dynamics and catalytic activity in MAO-N wild type and its evolved D5 variant. Our study reveals a delicate communication between both MAO-N subunits that impacts the active site architecture, and thus its catalytic efficiency. In both MAO-N WT and the laboratory evolved D5 variant, the ß-hairpin conformation in one of the monomers affects the productive binding of the substrate in the active site of the other subunit. However, both MAO-N WT and D5 variants show a quite different behaviour due to the distal mutations introduced experimentally with Directed Evolution. </p>

Regio- and Stereoselective Conjugate Addition of Aldehydes to β-Tosyl Enones under the Catalysis of a Binaphthyl-Modified Chiral Amine

2015 ◽  
Vol 54 (29) ◽  
pp. 8462-8465 ◽  
Author(s):  
Taichi Kano ◽  
Hisashi Sugimoto ◽  
Hiroki Maruyama ◽  
Keiji Maruoka
Keyword(s):  
Conjugate Addition ◽  
Chiral Amine
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