A New Phenanthroline Ligand and the Spontaneous Resolution of its Homoleptic Copper(I) Complex

2020 ◽  
Vol 2020 (47) ◽  
pp. 7320-7326
Author(s):  
Jordan L. Appleton ◽  
Vincent Silber ◽  
Lydia Karmazin ◽  
Corinne Bailly ◽  
Jean‐Claude Chambron ◽  
...  
Keyword(s):  
Spontaneous Resolution ◽  
Phenanthroline Ligand

scholarly journals Cover Feature: A New Phenanthroline Ligand and the Spontaneous Resolution of its Homoleptic Copper(I) Complex (Eur. J. Org. Chem. 47/2020)

2020 ◽  
Vol 2020 (47) ◽  
pp. 7253-7253
Author(s):  
Jordan L. Appleton ◽  
Vincent Silber ◽  
Lydia Karmazin ◽  
Corinne Bailly ◽  
Jean‐Claude Chambron ◽  
...  
Keyword(s):  
Spontaneous Resolution ◽  
Phenanthroline Ligand

A Case of Spontaneous Resolution of Castleman's Disease in the Neck

2012 ◽  
Vol 55 (11) ◽  
pp. 736
Author(s):  
Seong-Hyun Yun ◽  
Soo-Ryang Chae ◽  
Dong-Joon Yoo ◽  
Young-Hoon Joo
Keyword(s):  
Castleman’S Disease ◽  
Spontaneous Resolution ◽  
Castleman's Disease

Spontaneous resolution of hypothalamic amenorrhea post diagnostic GnRH test

2015 ◽  
Author(s):  
G K Dimitriadis ◽  
M O Weickert ◽  
T M Barber ◽  
H S Randeva
Keyword(s):  
Spontaneous Resolution ◽  
Hypothalamic Amenorrhea

Iridium-Catalyzed Silylation of C-H bonds in Unactivated Arenes: A Sterically-Encumbered Phenanthroline Ligand Accelerates Catalysis Enabling New Reactivity

2019 ◽  
Author(s):  
Caleb Karmel ◽  
Zhewei Chen ◽  
John Hartwig
Keyword(s):  
High Activity ◽  
Functional Group ◽  
Activity Analysis ◽  
High Reactivity ◽  
High Yield ◽  
Phen Ligand ◽  
Mechanistic Studies ◽  
Phenanthroline Ligand ◽  
First Time ◽  
New System

We report a new system for the silylation of aryl C-H bonds. The combination of [Ir(cod)(OMe)]<sub>2</sub> and 2,9-Me<sub>2</sub>-phenanthroline (2,9-Me<sub>2</sub>phen) catalyzes the silylation of arenes at lower temperatures and with faster rates than those reported previously, when the hydrogen byproduct is removed, and with high functional group tolerance and regioselectivity. Inhibition of reactions by the H<sub>2</sub> byproduct is shown to limit the silylation of aryl C-H bonds in the presence of the most active catalysts, thereby masking their high activity. Analysis of initial rates uncovered the high reactivity of the catalyst containing the sterically hindered 2,9-Me<sub>2</sub>phen ligand but accompanying rapid inhibition by hydrogen. With this catalyst, under a flow of nitrogen to remove hydrogen, electron-rich arenes, including those containing sensitive functional groups, undergo silylation in high yield for the first time, and arenes that underwent silylation with prior catalysts react over much shorter times with lower catalyst loadings. The synthetic value of this methodology is demonstrated by the preparation of key intermediates in the synthesis of medicinally important compounds in concise sequences comprising silylation and functionalization. Mechanistic studies demonstrate that the cleavage of the aryl C-H bond is reversible and that the higher rates observed with the 2,9-Me<sub>2</sub>phen ligand is due to a more thermodynamically favorable oxidative addition of aryl C-H bonds.

Spontaneous resolution of an acute subdural haematoma

2002 ◽  
Vol 16 (6) ◽  
pp. 609-610 ◽  
Author(s):  
R. J. Edwards ◽  
G. W. Britz ◽  
G. R. Critchley
Keyword(s):  
Subdural Haematoma ◽  
Spontaneous Resolution ◽  
Acute Subdural Haematoma
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