Flavin/I2 -Catalyzed Aerobic Oxidative C-H Sulfenylation of Aryl-Fused Cyclic Amines

2020 ◽  
Vol 2020 (25) ◽  
pp. 3889-3895 ◽  
Author(s):  
Xinpeng Jiang ◽  
Zongchen Zhao ◽  
Zhifeng Shen ◽  
Keda Chen ◽  
Liyun Fang ◽  
...  
Keyword(s):  
Cyclic Amines

Copper(II) mediated C-8 amination of 1-naphthylamide derivatives with acyclic and cyclic amines

2021 ◽  
pp. 152858
Author(s):  
Tapan Sahoo ◽  
Souvik Sarkar ◽  
Subhash Chandra Ghosh
Keyword(s):  
Cyclic Amines

Design, Synthesis, and Characterization of Novel CXCR4 Antagonists Featuring Cyclic Amines

ChemMedChem ◽  
2020 ◽  
Vol 15 (13) ◽  
pp. 1150-1162
Author(s):  
Yu Lin ◽  
Zhanhui Li ◽  
Haikuo Ma ◽  
Yujie Wang ◽  
Xu Wang ◽  
...  
Keyword(s):  
Synthesis And Characterization ◽  
Design Synthesis ◽  
Cyclic Amines ◽  
Cxcr4 Antagonists

Synthesis of Medium-Sized Cyclic Amines by Selective Ring Cleavage of Sulfonylated Bicyclic Amines

2001 ◽  
Vol 3 (19) ◽  
pp. 2957-2960 ◽  
Author(s):  
Fátima Iradier ◽  
Ramón Gómez Arrayás ◽  
Juan Carlos Carretero
Keyword(s):  
Ring Cleavage ◽  
Cyclic Amines

ChemInform Abstract: IBX-Mediated Oxidation of Unactivated Cyclic Amines: Application in Highly Diastereoselective Oxidative Ugi-Type and Aza-Friedel-Crafts Reactions.

ChemInform ◽  
2016 ◽  
Vol 47 (7) ◽  
pp. no-no
Author(s):  
C. de Graaff ◽  
L. Bensch ◽  
Matthijs J. van Lint ◽  
E. Ruijter ◽  
R. V. A. Orru
Keyword(s):  
Cyclic Amines ◽  
Mediated Oxidation

Process Development of Imine Reductase-Catalyzed Enantioselective Synthesis of Cyclic Amines

2016 ◽  
Vol 88 (9) ◽  
pp. 1251-1251
Author(s):  
N. Zumbrägel ◽  
D. Wetzl ◽  
H. Iding ◽  
H. Gröger
Keyword(s):  
Process Development ◽  
Enantioselective Synthesis ◽  
Cyclic Amines

scholarly journals A new one-pot three-component synthesis of 4-aryl-6-cycloamino-1,3,5-triazin-2-amines under microwave irradiation

Synthesis ◽  
2021 ◽  
Author(s):  
Muhammad Syafiq Bin Shahari ◽  
Ahmad Junaid ◽  
Edward R. T. Tiekink ◽  
Anton V. Dolzhenko
Keyword(s):  
Microwave Irradiation ◽  
Aromatic Aldehydes ◽  
Antileukemic Activity ◽  
One Pot ◽  
Biological Screening ◽  
X Ray ◽  
X Ray Crystallography ◽  
Cyclic Amines ◽  
Three Component Reaction ◽  
Fast Synthesis

A new method for the fast synthesis of diverse 4-aryl-6-cycloamino-1,3,5-triazin-2-amines was developed. The synthesis is performed under microwave irradiation in a one-pot manner from cyanoguanidine, aromatic aldehydes, and cyclic amines. Their three-component reaction in the presence of hydrochloric acid produced dihydrotriazines, which were then converted (without isolation) to the targeted compounds via aromatic dehydrogenation in the presence of alkali. The reaction tolerated various aromatic aldehydes (including heterocyclic) and cyclic amines. Crystal structures of two representative 4-aryl-6-morpholino-1,3,5-triazin-2-amines were established by X-ray crystallography. The results of preliminary biological screening identified potent antileukemic activity for 6-(3,4-dihydroisoquinolin-2(1<i>H</i>)-yl)-4-phenyl-1,3,5-triazin-2-amine.

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