PPh3 /Selectfluor-Mediated Transformation of Carboxylic Acids into Acid Anhydrides and Acyl Fluorides and Its Application in Amide and Ester Synthesis

2019 ◽  
Vol 2019 (34) ◽  
pp. 5998-6002 ◽  
Author(s):  
Zhen Yang ◽  
Siwei Chen ◽  
Fang Yang ◽  
Chenxi Zhang ◽  
You Dou ◽  
...  
Keyword(s):  
Carboxylic Acids ◽  
Ester Synthesis ◽  
Acid Anhydrides

scholarly journals The Reaction of Carboxylic Acids, Esters, and Acid Anhydrides with Various Alkenylmagnesium Bromides

1977 ◽  
Vol 26 (5) ◽  
pp. 291-294
Author(s):  
Shoji WATANABE ◽  
Tsutomu FUJITA ◽  
Kyoichi SUGA ◽  
Norio SAITO
Keyword(s):  
Carboxylic Acids ◽  
Acid Anhydrides

Isocarbostyrils. II. The Conversion of 2-Methyl-4-acyl-5-nitroisocarbostyrils to 2-Substituted Indole-4-carboxylic Acids

1971 ◽  
Vol 49 (17) ◽  
pp. 2797-2802 ◽  
Author(s):  
D. E. Horning ◽  
G. Lacasse ◽  
J. M. Muchowski
Keyword(s):  
Sulfuric Acid ◽  
Carboxylic Acid ◽  
Carboxylic Acids ◽  
Alkaline Hydrolysis ◽  
Mannich Reaction ◽  
Reductive Cyclization ◽  
Acid Catalyzed ◽  
Acid Anhydrides ◽  
Hydrolysis Of ◽  
Derivatives Of

The sulfuric acid catalyzed acylation of 2-methyl-5-nitroisocarbostyril with carboxylic acid anhydrides gave the corresponding 4-acylated derivatives 3, which underwent reductive cyclization to 2-substituted derivatives of 4-methyl-1,3,4,5-tetrahydropyrrolo[4.3.2.de]isoquinolin-5-one (4). Alkaline hydrolysis of the six-membered lactam in 4 was accompanied by a retro-Mannich reaction to produce 2-substituted indole-4-carboxylic acids in about 40 % overall yield from 3.

Polymer-SupportedO-Benzyl andO-Allylisoureas:  Convenient Preparation and Use in Ester Synthesis from Carboxylic Acids

2003 ◽  
Vol 5 (6) ◽  
pp. 853-856 ◽  
Author(s):  
Stefano Crosignani ◽  
Peter D. White ◽  
Rene Steinauer ◽  
Bruno Linclau
Keyword(s):  
Carboxylic Acids ◽  
Ester Synthesis ◽  
Convenient Preparation

Facile and direct synthesis of symmetrical acid anhydrides using a newly prepared powerful and efficient mixed reagent

2015 ◽  
Vol 69 (3) ◽  
Author(s):  
Hamed Rouhi-Saadabad ◽  
Batool Akhlaghinia
Keyword(s):  
Carboxylic Acids ◽  
Room Temperature ◽  
Low Cost ◽  
Direct Synthesis ◽  
Reaction Conditions ◽  
Experimental Procedure ◽  
Short Reaction Time ◽  
Acid Anhydrides ◽  
Work Up ◽  
Trichloroisocyanuric Acid

AbstractAn efficient mixed reagent for direct synthesis of symmetrical carboxylic anhydrides from carboxylic acids has been prepared. Carboxylic acids are converted to anhydrides using triphenylphosphine/ trichloroisocyanuric acid under mild reaction conditions at room temperature. Short reaction time, excellent yields of products, low cost, availability of reagents, simple experimental procedure, and easy work-up of the products are the main advantages of the presented method.

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