scholarly journals Controlling Photooxygenation with a Bifunctional Quinine-BODIPY Catalyst: towards Asymmetric Hydroxylation of β-Dicarbonyl Compounds

2019 ◽  
Vol 2019 (37) ◽  
pp. 6352-6358 ◽  
Author(s):  
Jérôme Fischer ◽  
Lucas Mele ◽  
Hélène Serier-Brault ◽  
Pierrick Nun ◽  
Vincent Coeffard
Keyword(s):  
Dicarbonyl Compounds ◽  
Asymmetric Hydroxylation

scholarly journals Chiral Ru/PNNP complexes in catalytic and stoichiometric electrophilic O- and F-atom transfer to 1,3-dicarbonyl compounds

2006 ◽  
Vol 78 (2) ◽  
pp. 391-396 ◽  
Author(s):  
Cristina Bonaccorsi ◽  
Martin Althaus ◽  
Claus Becker ◽  
Antonio Togni ◽  
Antonio Mezzetti
Keyword(s):  
Atom Transfer ◽  
Tetradentate Ligand ◽  
Dicarbonyl Compounds ◽  
Asymmetric Hydroxylation

The asymmetric hydroxylation and fluorination catalyst [Ru(OEt2)2(PNNP)]2+ (PNNP = chiral tetradentate ligand with a P2N2 donor set) reacts with 1,3-dicarbonyl compounds to give dicationic adducts and, upon deprotonation, the corresponding enolato complexes. The relevance of these species to catalytic O- and F-transfer is investigated.

Dicarbonyl derived post-translational modifications: chemistry bridging biology and aging-related disease

2020 ◽  
Vol 64 (1) ◽  
pp. 97-110
Author(s):  
Christian Sibbersen ◽  
Mogens Johannsen
Keyword(s):  
Mass Spectrometry ◽  
Future Research ◽  
Amino Acid Residues ◽  
Post Translational Modification ◽  
Dicarbonyl Compounds ◽  
Protein Targets ◽  
Post Translational Modifications ◽  
Reactive Protein ◽  
Glycation End Products ◽  
Direct Mass Spectrometry

Abstract In living systems, nucleophilic amino acid residues are prone to non-enzymatic post-translational modification by electrophiles. α-Dicarbonyl compounds are a special type of electrophiles that can react irreversibly with lysine, arginine, and cysteine residues via complex mechanisms to form post-translational modifications known as advanced glycation end-products (AGEs). Glyoxal, methylglyoxal, and 3-deoxyglucosone are the major endogenous dicarbonyls, with methylglyoxal being the most well-studied. There are several routes that lead to the formation of dicarbonyl compounds, most originating from glucose and glucose metabolism, such as the non-enzymatic decomposition of glycolytic intermediates and fructosyl amines. Although dicarbonyls are removed continuously mainly via the glyoxalase system, several conditions lead to an increase in dicarbonyl concentration and thereby AGE formation. AGEs have been implicated in diabetes and aging-related diseases, and for this reason the elucidation of their structure as well as protein targets is of great interest. Though the dicarbonyls and reactive protein side chains are of relatively simple nature, the structures of the adducts as well as their mechanism of formation are not that trivial. Furthermore, detection of sites of modification can be demanding and current best practices rely on either direct mass spectrometry or various methods of enrichment based on antibodies or click chemistry followed by mass spectrometry. Future research into the structure of these adducts and protein targets of dicarbonyl compounds may improve the understanding of how the mechanisms of diabetes and aging-related physiological damage occur.

ChemInform Abstract: CONDENSATION OF O-AMINOPHENOL AND α-DICARBONYL COMPOUNDS. PART 1. BENZOXAZINES

1978 ◽  
Vol 9 (18) ◽  
Author(s):  
E. BELGODERE ◽  
R. BOSSIO ◽  
V. PARRINI ◽  
R. PEPINO
Keyword(s):  
Dicarbonyl Compounds

scholarly journals Stereoselective Tandem Iridium-Catalyzed Alkene Isomerization-Cope Rearrangement of ω-diene Epoxides: Efficient Access to Acyclic 1,6-Dicarbonyl Compounds

2021 ◽  
Author(s):  
Rahul Suresh ◽  
Itai Massad ◽  
Ilan Marek
Keyword(s):  
Bond Cleavage ◽  
Cope Rearrangement ◽  
Dicarbonyl Compounds ◽  
Alkene Isomerization ◽  
Efficient Access

The Cope rearrangement of 2,3-divinyloxiranes, a rare example of epoxide C-C bond cleavage, results in 4,5-dihydrooxepines which are amenable to hydrolysis, furnishing 1,6-dicarbonyl compounds containing two contiguous stereocenters at the 3- and 4- positions. We employ...

ChemInform Abstract: CONDENSATION OF 4-AMINO-3-HYDRAZINO-1,2,4-TRIAZOLINE-5-THIONE WITH α- AND β-DICARBONYL COMPOUNDS

1978 ◽  
Vol 9 (36) ◽  
Author(s):  
A. D. SINEGIBSKAYA ◽  
K. I. PASHKEVICH ◽  
V. I. SALOUTIN ◽  
N. A. KLYUEV ◽  
E. KH. DANK
Keyword(s):  
Dicarbonyl Compounds
Sign in / Sign up

Export Citation Format

Share Document